Results 1 to 10 of about 15,074 (176)
High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation [PDF]
mBio, 2016 The major transformation activity of the high-risk human papillomaviruses (HPV) is associated with the E7 oncoprotein. The interaction of HPV E7 with retinoblastoma family proteins is important for several E7 activities; however, this interaction does ...
Elizabeth A. White +2 more
doaj +6 more sources
The papillomavirus E7 proteins. [PDF]
Virology, 2013 E7 is an accessory protein that is not encoded by all papillomaviruses. The E7 amino terminus contains two regions of similarity to conserved regions 1 and 2 of the adenovirus E1A protein, which are also conserved in the simian vacuolating virus 40 large tumor antigen.
Roman A, Munger K.
europepmc +3 more sources
Characterization of patient-derived HPV16 E6 and E7 variant alleles [PDF]
Journal of VirologyHuman papillomavirus type 16 (HPV16) is the most prevalent carcinogenic HPV type. Many HPV16 sequence variants have been described, some of which cause protein-coding mutations.
Miranda Grace +7 more
doaj +2 more sources
The human papillomavirus E7 proteins associate with p190RhoGAP and alter its function. [PDF]
J Virol, 2014 ABSTRACT Using mass spectrometry, we identified p190RhoGAP (p190) as a binding partner of human papillomavirus 16 (HPV16) E7. p190 belongs to the GTPase activating protein (GAP) family and is one of the primary GAPs for RhoA. GAPs stimulate the intrinsic GTPase activity of the Rho proteins, leading to Rho inactivation and influencing numerous
Todorovic B +8 more
europepmc +6 more sources
Transforming Properties of Beta-3 Human Papillomavirus E6 and E7 Proteins
mSphere, 2020 The beta human papillomaviruses (HPVs) are subdivided into 5 species (beta-1 to beta-5), and they were first identified in the skin. However, the beta-3 species appears to be more highly represented in the mucosal epithelia than in the skin.
Lucia Minoni +11 more
doaj +6 more sources
An mRNA-encoded scFv antibody targeting the helix-α3 of HPV18 E7 oncoprotein as a novel antiviral strategy [PDF]
mBioDespite the availability of prophylactic vaccines, human papillomavirus (HPV) infection remains the leading viral cause of cancer worldwide. The HPV E7 oncoprotein is a key factor in cancer progression by degrading host tumor suppressor proteins, thus ...
Feng Han +17 more
doaj +2 more sources
Human Papillomavirus: Update in Bridging Basic Science to Clinical and Public Health Innovations. [PDF]
Health Sci RepABSTRACT Human papillomavirus (HPV), a non‐enveloped, double‐strand DNA viral pathogen, is intricately linked with the onset of various cancers, including cervical cancer and head and neck cancers. The present paper delves into HPV's ancient recognition and significant milestones such as the discovery of its role in oncogenesis and the development of ...
Beygnejad F +4 more
europepmc +2 more sources
PLoS Pathogens, 2023 Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers. Species-specific barriers limit the ability to study HPV pathogenesis in animal models.
James C Romero-Masters +12 more
doaj +3 more sources
mBio, 2021 The species specificity of papillomaviruses has been a significant roadblock for performing in vivo pathogenesis studies in common model organisms. The Mus musculus papillomavirus type 1 (MmuPV1) causes cutaneous papillomas that can progress to squamous ...
Tao Wei +6 more
doaj +1 more source
Synergistic Interaction Between HPV-16 E7 Oncoprotein and Severe Vitamin A Deficiency in Regulating Adaptive Immunity in a Preclinical Cervical Cancer Model. [PDF]
J Med VirolABSTRACT Persistent infection with High‐Risk Human Papillomavirus (HR‐HPV), particularly HPV‐16, is the main driver of cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). However, HR‐HPV infection alone is insufficient for malignant progression and nutritional cofactors such as Vitamin A deficiency, may influence cervical neoplasia ...
Chávez-Ríos A +7 more
europepmc +2 more sources