Results 1 to 10 of about 15,128 (181)

High-Risk Human Papillomavirus E7 Proteins Target PTPN14 for Degradation [PDF]

mBio, 2016
The major transformation activity of the high-risk human papillomaviruses (HPV) is associated with the E7 oncoprotein. The interaction of HPV E7 with retinoblastoma family proteins is important for several E7 activities; however, this interaction does ...
Elizabeth A. White, Karl Münger, Peter M. Howley   +2 more
doaj   +6 more sources

Characterization of patient-derived HPV16 E6 and E7 variant alleles [PDF]

Journal of Virology
Human papillomavirus type 16 (HPV16) is the most prevalent carcinogenic HPV type. Many HPV16 sequence variants have been described, some of which cause protein-coding mutations.
Miranda Grace, Harshita Beeravolu, Ahmad Alhamshari, Josipa Skelin, Si-Young Kiessling, Andrew Bohm, Elizabeth A. White, Karl Munger   +7 more
doaj   +2 more sources

An mRNA-encoded scFv antibody targeting the helix-α3 of HPV18 E7 oncoprotein as a novel antiviral strategy [PDF]

mBio
Despite the availability of prophylactic vaccines, human papillomavirus (HPV) infection remains the leading viral cause of cancer worldwide. The HPV E7 oncoprotein is a key factor in cancer progression by degrading host tumor suppressor proteins, thus ...
Feng Han, Xin-ying Guo, Ling-yan Cui, Meng-xuan Zhang, Ya-rong Zeng, Gui-qiang Wang, Jin-jin Li, Xin Chi, Ming-xia Jiang, Yue-ting Xiong, Li-zhi Zhou, Qing-bing Zheng, Hai Yu, Jun Zhang, Ting-ting Li, Ying Gu, Ning-shao Xia, Shaowei Li   +17 more
doaj   +2 more sources

MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease.

PLoS Pathogens, 2023
Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers. Species-specific barriers limit the ability to study HPV pathogenesis in animal models.
James C Romero-Masters, Miranda Grace, Denis Lee, Joshua Lei, Melanie DePamphilis, Darya Buehler, Rong Hu, Ella Ward-Shaw, Simon Blaine-Sauer, Nathalie Lavoie, Elizabeth A White, Karl Munger, Paul F Lambert   +12 more
doaj   +3 more sources

The Mus musculus Papillomavirus Type 1 E7 Protein Binds to the Retinoblastoma Tumor Suppressor: Implications for Viral Pathogenesis

mBio, 2021
The species specificity of papillomaviruses has been a significant roadblock for performing in vivo pathogenesis studies in common model organisms. The Mus musculus papillomavirus type 1 (MmuPV1) causes cutaneous papillomas that can progress to squamous ...
Tao Wei, Miranda Grace, Aayushi Uberoi, James C. Romero-Masters, Denis Lee, Paul F. Lambert, Karl Munger   +6 more
doaj   +1 more source

Fused toes homolog, a potential molecular regulator of human papillomavirus type 16 E6 and E7 oncoproteins in cervical cancer.

PLoS ONE, 2022
Human papillomavirus type 16 (HPV16) plays a major role in the development of cervical cancer. The oncogenic potential of HPV16 is attributed to E6 and E7 oncoproteins.
Prabakaran D S, Pankaj Kumar Chaturvedi, Dineshkumar Krishnamoorthy, Young-Seok Seo, Mallikarjuna Thippana, Woo-Yoon Park   +5 more
doaj   +2 more sources

Molecular Mechanisms of MmuPV1 E6 and E7 and Implications for Human Disease

Viruses, 2022
Human papillomaviruses (HPVs) cause a substantial amount of human disease from benign disease such as warts to malignant cancers including cervical carcinoma, head and neck cancer, and non-melanoma skin cancer.
James C. Romero-Masters, Paul F. Lambert, Karl Munger   +2 more
doaj   +1 more source

Localisation of human papillomavirus 16 E7 oncoprotein changes with cell confluence. [PDF]

PLoS ONE, 2011
E7 is one of the best studied proteins of human papillomavirus type 16, largely because of its oncogenic potential linked to cervical cancer. Yet the sub-cellular location of E7 remains confounding, even though it has been shown to be able to shuttle ...
Joanna Laurson, Kenneth Raj
doaj   +1 more source

The canine papillomavirus and gamma HPV E7 proteins use an alternative domain to bind and destabilize the retinoblastoma protein. [PDF]

PLoS Pathogens, 2010
The high-risk HPV E6 and E7 proteins cooperate to immortalize primary human cervical cells and the E7 protein can independently transform fibroblasts in vitro, primarily due to its ability to associate with and degrade the retinoblastoma tumor suppressor
Jingang Wang, Dan Zhou, Anjali Prabhu, Richard Schlegel, Hang Yuan   +4 more
doaj   +1 more source

The Role of Long Noncoding RNAs in Human Papillomavirus-associated Pathogenesis

Pathogens, 2020
Infections with high-risk human papillomaviruses cause ~5% of all human cancers. E6 and E7 are the only viral genes that are consistently expressed in cancers, and they are necessary for tumor initiation, progression, and maintenance.
Surendra Sharma, Karl Munger
doaj   +1 more source