Results 11 to 20 of about 15,074 (137)
The canine papillomavirus and gamma HPV E7 proteins use an alternative domain to bind and destabilize the retinoblastoma protein. [PDF]
PLoS Pathogens, 2010 The high-risk HPV E6 and E7 proteins cooperate to immortalize primary human cervical cells and the E7 protein can independently transform fibroblasts in vitro, primarily due to its ability to associate with and degrade the retinoblastoma tumor suppressor
Jingang Wang +4 more
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The Role of Long Noncoding RNAs in Human Papillomavirus-associated Pathogenesis
Pathogens, 2020 Infections with high-risk human papillomaviruses cause ~5% of all human cancers. E6 and E7 are the only viral genes that are consistently expressed in cancers, and they are necessary for tumor initiation, progression, and maintenance.
Surendra Sharma, Karl Munger
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Fusion protein vaccines targeting two tumor antigens generate synergistic anti-tumor effects. [PDF]
PLoS ONE, 2013 INTRODUCTION: Human papillomavirus (HPV) has been consistently implicated in causing several kinds of malignancies, and two HPV oncogenes, E6 and E7, represent two potential target antigens for cancer vaccines.
Wen-Fang Cheng +6 more
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ZER1 Contributes to the Carcinogenic Activity of High-Risk HPV E7 Proteins
mBio, 2022 Human papillomavirus (HPV) E7 proteins bind to host cell proteins to facilitate virus replication. Interactions between HPV E7 and host cell proteins can also drive cancer progression.
Joangela Nouel, Elizabeth A. White
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Scientific Reports, 2023 Human Papillomavirus (HPV) is the most common cause of sexually transmitted diseases and causes a wide range of pathologies including cervical carcinoma. Integration of the HR-HPV DNA into the host genome plays a crucial role in cervical carcinoma.
Bilal Ahmad Mir +9 more
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Structural Insights in Multifunctional Papillomavirus Oncoproteins
Viruses, 2018 Since their discovery in the mid-eighties, the main papillomavirus oncoproteins E6 and E7 have been recalcitrant to high-resolution structure analysis. However, in the last decade a wealth of three-dimensional information has been gained on both proteins
Irina Suarez, Gilles Trave
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High-Risk Human Papillomavirus Oncogenic E6/E7 mRNAs Splicing Regulation
Frontiers in Cellular and Infection Microbiology, 2022 High-risk human papillomavirus infection may develop into a persistent infection that is highly related to the progression of various cancers, including cervical cancer and head and neck squamous cell carcinomas.
Yunji Zheng +3 more
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Frontiers in Microbiology, 2021 Human papillomavirus type 8 (HPV8) is associated with the development of non-melanoma skin cancer. In the past we already delved into the mechanisms involved in keratinocyte invasion, showing that the viral E7 oncoprotein is a key player that drives ...
Matthias Kirschberg +8 more
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Redox Biology, 2017 Infection with oncogenic human papillomavirus induces deregulation of cellular redox homeostasis. Virus replication and papillomavirus-induced cell transformation require persistent expression of viral oncoproteins E7 and E6 that must retain their ...
Gabriela Camporeale +8 more
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E7 Oncogene HPV58 Variants Detected in Northeast Brazil: Genetic and Functional Analysis
Microorganisms, 2023 Cervical cancer is associated with persistent infections by high-risk Human Papillomavirus (HPV) types that may have nucleotide polymorphisms and, consequently, different oncogenic potentials.
Bárbara Simas Chagas +12 more
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