Results 21 to 30 of about 16,162 (223)
Cellular Oncology, 2009 Background: A role for cutaneous human β-papillomavirus (HPV) types as co-factors in the development of non-melanoma skin cancer has been postulated. Here we have investigated the effects of E7 expression on keratinocyte differentiation, proliferation ...
K. Westphal +3 more
doaj +2 more sources
PLoS Pathogens, 2023 Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers. Species-specific barriers limit the ability to study HPV pathogenesis in animal models.
James C Romero-Masters +12 more
doaj +3 more sources
mBio, 2021 The species specificity of papillomaviruses has been a significant roadblock for performing in vivo pathogenesis studies in common model organisms. The Mus musculus papillomavirus type 1 (MmuPV1) causes cutaneous papillomas that can progress to squamous ...
Tao Wei +6 more
doaj +1 more source
PLoS ONE, 2022 Human papillomavirus type 16 (HPV16) plays a major role in the development of cervical cancer. The oncogenic potential of HPV16 is attributed to E6 and E7 oncoproteins.
Prabakaran D S +5 more
doaj +2 more sources
The human papillomavirus E7 proteins associate with p190RhoGAP and alter its function. [PDF]
J Virol, 2014 ABSTRACT Using mass spectrometry, we identified p190RhoGAP (p190) as a binding partner of human papillomavirus 16 (HPV16) E7. p190 belongs to the GTPase activating protein (GAP) family and is one of the primary GAPs for RhoA. GAPs stimulate the intrinsic GTPase activity of the Rho proteins, leading to Rho inactivation and influencing numerous
Todorovic B +8 more
europepmc +6 more sources
Molecular Mechanisms of MmuPV1 E6 and E7 and Implications for Human Disease
Viruses, 2022 Human papillomaviruses (HPVs) cause a substantial amount of human disease from benign disease such as warts to malignant cancers including cervical carcinoma, head and neck cancer, and non-melanoma skin cancer.
James C. Romero-Masters +2 more
doaj +1 more source
Papillomavirus polypeptides E6 and E7 are zinc-binding proteins [PDF]
Journal of Virology, 1989 Papillomavirus proteins E6 and E7 have Cys-X-X-Cys repeats which have been suggested to mediate zinc binding. We have developed a modification of an assay that detects zinc binding to proteins immobilized on filters. Using well-characterized metalloproteins, we show that, under reducing conditions, this assay distinguishes proteins that coordinate zinc
M S, Barbosa, D R, Lowy, J T, Schiller
openaire +2 more sources
Allosteric Activation of Acid α-Glucosidase by the Human Papillomavirus E7 Protein [PDF]
Journal of Biological Chemistry, 2000 Changes in the cellular carbohydrate metabolism are a hallmark of malignant transformation and represent one of the earliest discernible events in tumorigenesis. In the early stages of certain epithelial cancers, a metabolic switch is regularly observed, in which slowly growing glycogenotic cells are converted to highly proliferating basophilic cells ...
Zwerschke, W +8 more
openaire +3 more sources
The E6E7 oncoproteins of cutaneous human papillomavirus type 38 interfere with the interferon pathway [PDF]
, 2008 Non-melanoma skin cancer is the most frequent malignancy in Caucasian populations. Evidence suggests the involvement of cutaneous Human Papillomavirus (HPV) of the genus beta () in this disease. The ability of E6 and E7 of mucosal HPV to promote cellular
Tommasino, M. +13 more
core +1 more source
HPV-18 transformed cells fail to arrest in G1 in response to quercetin treatment [PDF]
, 2005 Previous work with primary human keratinocytes demonstrated that quercetin, a potent mutagen found in high levels in bracken fern (Pteridium aquilinum), arrested cells in G1 with concomitant elevation of the cyclin-dependent kinase inhibitor (cdki ...
Beniston, R.G., Campo, M.S.
core +1 more source