Results 31 to 40 of about 16,162 (223)

Epigenetic repression of E-cadherin by human papillomavirus 16 E7 protein [PDF]

Carcinogenesis, 2010
A common feature shared between several human cancer-associated viruses, such as Epstein-Barr virus, Hepatitis B virus and Hepatitis C virus, and Human papillomavirus (HPV) is the ability to reduce the expression of cellular E-cadherin. Since E-cadherin is used by Langerhans cells to move through the stratified epithelium, its reduction may affect the ...
Laurson, Joanna, Khan, Sadaf, Chung, Rachel, Cross, Karen, Raj, Kenneth   +4 more
openaire   +2 more sources

E5 protein of human papillomavirus type 16 selectively downregulates surface HLA class I [PDF]

, 2005
Papillomaviruses have evolved mechanisms that result in escape from host immune surveillance. The E5 protein is expressed early in papillomavirus infection in the deep layers of the infected epithelium.
Marchetti, Barbara, O'Brien, P.M., Ashrafi, G. Hossein, Haghshenas, Mohammad R., O'Brien, Philippa M., Ashrafi, G.H., Haghshenas, M.R., Campo, M.S., Marchetti, B., Campo, M. Saveria   +9 more
core   +1 more source

Human Papillomavirus E7 Requires the Protease Calpain to Degrade the Retinoblastoma Protein [PDF]

Journal of Biological Chemistry, 2007
Cervical cancers transformed by high risk human papilloma virus (HPV) express the E7 oncoprotein, which accelerates the degradation of the retinoblastoma protein (Rb). Here we show that the E7-mediated degradation of Rb requires the calcium-activated cysteine protease, calpain.
Grant A, Darnell, Wayne A, Schroder, Toni M, Antalis, Eleanore, Lambley, Lee, Major, Joy, Gardner, Geoff, Birrell, Angel, Cid-Arregui, Andreas, Suhrbier   +8 more
openaire   +2 more sources

Papillomavirus E5: the smallest oncoprotein with many functions [PDF]

, 2011
Papillomaviruses (PVs) are established agents of human and animal cancers. They infect cutaneous and mucous epithelia. High Risk (HR) Human PVs (HPVs) are consistently associated with cancer of the uterine cervix, but are also involved in the ...
Roperto, S., Borzacchiello, G., Venuti Aldo, Sante Roperto, Corteggio, A., BORZACCHIELLO, GIUSEPPE, Giuseppe Borzacchiello, Roperto Sante, CORTEGGIO, ANNUNZIATA, Francesca Paolini, Nasir, L., A. Venuti, Paolini Francesca, Aldo Venuti, Paolini, F., L. Nasir, Lubna Nasir, Annunziata Corteggio, Corteggio Annunziata, F. Paolini, Borzacchiello Giuseppe, ROPERTO, SANTE, M.S. Campo, Maria S Campo, Nasir Lubna, Venuti, A., Campo, M.S., Campo Maria S   +27 more
core   +1 more source

A point mutational analysis of human papillomavirus type 16 E7 protein [PDF]

Journal of Virology, 1989
The E7 open reading frame of human papillomavirus type 16 (HPV16) has been shown to be selectively retained in cervical tumors and to encode both transforming and trans-activating functions in murine cells, supporting the notion that expression of E7 contributes towards the progression of premalignant cervical lesions.
C, Edmonds, K H, Vousden
openaire   +2 more sources

Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts [PDF]

Journal of Virology, 1993
Human papillomaviruses (HPVs) are the etiologic agents responsible for benign epithelial proliferative disorders including genital warts and are a contributory factor in the pathogenesis of cervical cancer. HPVs demonstrate strict species and cell-type specificity, which is manifested by the inability of these viruses to induce disease in any species ...
D, Defeo-Jones, G A, Vuocolo, K M, Haskell, M G, Hanobik, D M, Kiefer, E M, McAvoy, M, Ivey-Hoyle, J L, Brandsma, A, Oliff, R E, Jones   +9 more
openaire   +2 more sources

Downregulation of major histocompatibility complex class I in bovine papillomas [PDF]

, 2004
Bovine papillomavirus (BPV) induces papillomas in cattle; in the great majority of cases, these regress due to the host immune response, but they can persist and progress to malignancy.
Marchetti, B, Araibi, E.H., Ashrafi, G.H., Campo, M.S., Marchetti, B., Araibi, E. H.   +5 more
core   +1 more source

Interactions with Pocket Proteins Contribute to the Role of Human Papillomavirus Type 16 E7 in the Papillomavirus Life Cycle [PDF]

Journal of Virology, 2005
ABSTRACT Human papillomaviruses (HPVs), most commonly the HPV16 genotype, are the principle etiological determinant for cervical cancer, a common cancer worldwide resulting in over 200,000 deaths annually. The oncogenic properties of HPVs are attributable in part to the virally encoded protein E7, best known for its ability to bind to and ...
Asha S, Collins, Tomomi, Nakahara, Anh, Do, Paul F, Lambert   +3 more
openaire   +2 more sources

Equine sarcoids: Bovine Papillomavirus type 1 transformed fibroblasts are sensitive to cisplatin and UVB induced apoptosis and show aberrant expression of p53 [PDF]

, 2012
Bovine papillomavirus type 1 infects not only cattle but also equids and is a causative factor in the pathogenesis of commonly occurring equine sarcoid tumours.
Finlay, M., Morgan Iain M, M Campo, Margaret Finlay, Campo M, Finlay Margaret, Yuan ZhengQiang, Lubna Nasir, Morgan, I.M., Campo, M., ZhengQiang Yuan, Iain M Morgan, Nasir Lubna, Yuan, Z., Nasir, L.   +14 more
core   +1 more source

Human papillomavirus 16 E7 protein is associated with the nuclear matrix. [PDF]

Proceedings of the National Academy of Sciences, 1991
The cellular localization of the human papillomavirus (HPV)-16 E7 gene product in the cell lines CaSki and SiHa has been determined by both biochemical and immunocytochemical methods. These measurements show E7 to be localized in the cell nucleus, specifically with the nonchromatin nuclear structure or nuclear matrix.
I, Greenfield, J, Nickerson, S, Penman, M, Stanley   +3 more
openaire   +2 more sources