Identification of Human Papillomavirus Type 16 E7 Protein by Monoclonal Antibodies
A number of human papillomavirus (HPV) type 16 proteins have recently been identified in human cervical carcinoma cell lines using polyclonal antisera against papillomavirus gene products expressed in Escherichia coli. E7 protein has been found to be the most abundant papillomavirus protein in these cells.
T, Oltersdorf +3 more
openaire +2 more sources
AKT1 loss correlates with episomal HPV16 in vulval intraepithelial neoplasia. [PDF]
Anogenital malignancy has a significant association with high-risk mucosal alpha-human papillomaviruses (alpha-PV), particularly HPV 16 and 18 whereas extragenital SCC has been linked to the presence of cutaneous beta and gamma-HPV types. Vulval skin may
Harwood Catherine A. +35 more
core +1 more source
Life cycle heterogeneity in animal models of human papillomavirus-associated disease
Animal papillomaviruses are widely used as models to study papillomavirus infection in humans despite differences in genome organization and tissue tropism. Here, we have investigated the extent to which animal models of papillomavirus infection resemble
Peh, W.L. +21 more
core +1 more source
Production of Polyclonal Antibody to the HPV58 E7 Protein and Its Detection in Cervical Cancer.
The persistent infection of high-risk human papillomavirus (HPV) is one of the most common causes of cervical cancer worldwide, and HPV type 58 is the third most common HPV type in eastern Asia.
Qiaoli Zheng +9 more
doaj +1 more source
Detection of Human Antibody against the Human Papillomavirus Type 16 E7 Protein [PDF]
We examined 500 human sera for the presence of antibody against the human papillomavirus type 16 E7 protein by enzyme‐linked immunosorbent assay with bacterially expressed fusion protein lac‐E7, and by radioimmunoprecipitation and immunofluorescence assays with the E7 protein expressed in monkey COS‐1 cells. The anti‐E7 antibody was detectable in 6 out
Hashido, Madoka +8 more
openaire +2 more sources
Isolation of three novel rat and mouse papillomaviruses and their genomic characterization. [PDF]
Despite a growing knowledge about the biological diversity of papillomaviruses (PV), only little is known about non-human PV in general and about PV mice models in particular.
Ingo Nindl (126623) +23 more
core +1 more source
Alignment of primate and murine Papillomavirus E7’s and PTPN14.
(A) Amino acid sequence alignment of the C-terminus of several primate, rodent, and bovine papillomavirus E7 proteins. R84, and L91 are two amino acids in HPV18 E7 that make contact with PTPN14 as determined by the HPV18 E7-PTPN14 crystal structure [63].
Nathalie Lavoie (2293762) +12 more
core +1 more source
Equine models in translational medicine: A comparative approach to human health
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh +1 more
wiley +1 more source
Functional studies of the Human Papillomavirus E7 protein. [PDF]
El is the major Human Papillomavirus transforming protein. Mutations in regions of E7 result in a loss or reduction of transforming activity even through wild type levels of pRB binding are retained, indicating the existence of additional cellular targets.
openaire +1 more source
Significance of serum antibodies against HPV E7, Hsp27, Hsp20 and Hp91 in Iranian HPV-exposed women
Background Among different types of human papillomavirus (HPV), types 16 and 18 were known to be high-risk agents causing mainly cervical cancer. Up to now, the potential of HPV E7 protein has been proved as a diagnostic marker of cervical cancer ...
Amitis Ramezani +4 more
doaj +1 more source

