Results 201 to 210 of about 54,359 (258)

Fecal AAV8 shedding and co-housing reduces EAE disease severity: implications for preclinical study design. [PDF]

Front Med (Lausanne)
Gaddie CD, Keeler GD.
europepmc   +1 more source

Helicase A determines the transcription program of T_H17 lineage differentiation and autoimmunity. [PDF]

Sci Adv
Su Y, Jiao A, Zhang X, Xu Y, Ping H, Zhu K, Wang Q, Yuan N, Gao Y, Ju B, Ding R, Wang N, He L, Lei L, Zhao Y, Zhang M, Zhang B.   +16 more
europepmc   +1 more source

Impaired T Follicular Regulatory Cell Function and Enhanced T Follicular Helper Cell Activity in Experimental Autoimmune Encephalomyelitis: Mechanistic Insights into CNS Autoimmunity. [PDF]

Int J Mol Sci
Hekimoglu G, Sevgin K, Yucel N, Yesilay G, Erguven SP, Seker M.   +5 more
europepmc   +1 more source

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On the Regulation of EAE

International Reviews of Immunology, 1993
This paper describes some of the factors involved in the regulation of EAE and of autoimmunity in general. The immunological homunculus is discussed.
Irun R Cohen, Felix Mor
exaly   +3 more sources

Immunolocalization of CCL2-expressing cells in EAE and EAE-MSC cerebral cortex

Italian Journal of Anatomy and Embryology, 2015
The chemokine CCL2 has been considered as a mediator of inflammation in different diseases of the central nervous system, including experimental autoimmune encephalomyelitis (EAE), where the chemokine mediates extravasation of mononuclear leukocytes and loss of microvessel barrier function [1].
Virgintino, Daniela, Errede, Mariella, Longo, Giovanna, Girolamo, Francesco, Morando, Sara, Petrosino, Valentina, De Rosbo, Nicole Kerlero, Uccelli, Antonio, Roncali, Luisa   +8 more
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EAE

Trends in Molecular Medicine, 2011
The high failure rate of immunotherapies in multiple sclerosis (MS) clinical trials demonstrates problems in translating new treatment concepts from animal models to the patient. One main reason for this 'immunotherapy gap' is the usage of immunologically immature, microbiologically clean and genetically homogeneous rodent strains.
't Hart, Bert A., Gran, Bruno, Weissert, Robert   +2 more
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EAE susceptibility in FVB mice

Journal of Neuroscience Research, 2000
The in vivo study of immunologic mechanisms in experimental allergic encephalomyelitis (EAE) requires, in some instances, the use of transgenic mice. As FVB mice represent a strain whose fertilized ova possess a relatively large pronucleus, this is a preferred strain in which to generate mice that are transgenic for a variety of genes.
A M, Baker, M C, Grekova, J R, Richert
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The Ups and Downs of EAE

International Reviews of Immunology, 1993
Experimental allergic encephalomyelitis (EAE) is considered the animal disease model for multiple sclerosis (MS) in humans. However, EAE is an acute disease whereas MS is a chronic disease. The on-off nature in both diseases of autoimmune reactivity suggests a regulatory response by the host, a response which can effect the autoreactive T cell by ...
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Induction of EAE

2008
Experimental autoimmune encephalomyelitis (EAE) can be induced by two principal approaches. The first is based on direct immunization with autoantigen in combination with different types of adjuvant. The second approach of inducing EAE consists in adoptive transfer of activated T cells that are specific for myelin-associated autoantigens of the central
Eli Ben-Chetrit, Stefan Brocke
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Induction of EAE in mice with recombinant human MOG, and treatment of EAE with a MOG peptide

Journal of Neuroimmunology, 1997
Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane glycoprotein expressed on the surface of central nervous system (CNS) myelin membranes, which has been shown to induce experimental autoimmune encephalomyelitis (EAE) in rodents. Here we describe the induction of EAE in SJL and (PLJ X SJL)F1 mice with truncated human recombinant MOG (thr-MOG,
B, Devaux, F, Enderlin, B, Wallner, D E, Smilek   +3 more
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