Results 211 to 220 of about 54,359 (258)
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2008
Adjuvants enhance autoantigens’ immunogenicity and play a major role in the induction of EAE. Complete Freund’s adjuvant (CFA) is the key adjuvant for cell-mediated immunity, including EAE. An additional adjuvant, pertussis toxin, is necessary for active EAE in mice.
Cris S Constantinescu +1 more
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Adjuvants enhance autoantigens’ immunogenicity and play a major role in the induction of EAE. Complete Freund’s adjuvant (CFA) is the key adjuvant for cell-mediated immunity, including EAE. An additional adjuvant, pertussis toxin, is necessary for active EAE in mice.
Cris S Constantinescu +1 more
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The EAE Textbook of Echocardiography
2011The EAE Textbook of Echocardiography is the official textbook of the European Association of Echocardiography (EAE). It serves the educational requirements of cardiologists and all clinical medical professionals, underpinning the structural training in the field in accordance with EAE aims and goals, and reflecting the EAE Core Syllabus.
Galiuto L +4 more
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2008
This chapter reviews the histological structure of the normal central nervous system and the basic pathology of inflammation and demyelination of this tissue. An outline of the pathogenesis of experimental autoimmune encephalomyelitis (EAE) is given and pathology of multiple sclerosis is reviewed.
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This chapter reviews the histological structure of the normal central nervous system and the basic pathology of inflammation and demyelination of this tissue. An outline of the pathogenesis of experimental autoimmune encephalomyelitis (EAE) is given and pathology of multiple sclerosis is reviewed.
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Surgical Endoscopy, 2020
The European Association for Endoscopic Surgery (EAES) strives to be a leader in promoting the development and expansion of minimally invasive surgery (MIS). Part of the association's mission statement is "to become an information hub for all practitioners of MIS".
Balaji Mahendran +8 more
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The European Association for Endoscopic Surgery (EAES) strives to be a leader in promoting the development and expansion of minimally invasive surgery (MIS). Part of the association's mission statement is "to become an information hub for all practitioners of MIS".
Balaji Mahendran +8 more
openaire +2 more sources
2008
This chapter reviews briefly the biology of myelin and describes the major CNS myelin proteins, the potential neuroantigens in EAE. The genetics of the principal myelin proteins are also discussed. Myelin glycolipids with potential role in CNS demyelinating disease and the enzymes involved in their synthesis are also reviewed.
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This chapter reviews briefly the biology of myelin and describes the major CNS myelin proteins, the potential neuroantigens in EAE. The genetics of the principal myelin proteins are also discussed. Myelin glycolipids with potential role in CNS demyelinating disease and the enzymes involved in their synthesis are also reviewed.
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The Journal of Immunology, 2016
Abstract TLR2 expression is enhanced in MS and EAE, but its role in these diseases is controversial. In adoptive transfer EAE, exogenous TLR ligands are not administered yet TLR2-deficient mice have been reported to develop attenuated disease. Despite this evidence for a disease-promoting function of TLR2, others have shown the opposite,
Emily J Anstadt +3 more
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Abstract TLR2 expression is enhanced in MS and EAE, but its role in these diseases is controversial. In adoptive transfer EAE, exogenous TLR ligands are not administered yet TLR2-deficient mice have been reported to develop attenuated disease. Despite this evidence for a disease-promoting function of TLR2, others have shown the opposite,
Emily J Anstadt +3 more
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2008
The EAE lesion is initiated by CD4+ T cells. Although this statement still holds, recent work has shown that CD8+ T cells and possibly γδ T cells can also contribute to pathology. The recovery phase of the disease poses more of a challenge with the potential for various regulatory T cell populations to halt the pathology.
Kelli Ryan, Stephen M Anderton
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The EAE lesion is initiated by CD4+ T cells. Although this statement still holds, recent work has shown that CD8+ T cells and possibly γδ T cells can also contribute to pathology. The recovery phase of the disease poses more of a challenge with the potential for various regulatory T cell populations to halt the pathology.
Kelli Ryan, Stephen M Anderton
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Ingested (oral) tocilizumab inhibits EAE
Cytokine, 2014Blocking the activity of IL-6 can inhibit autoimmune diseases such as rheumatoid arthritis and Crohn's disease.We examined whether an antibody against IL-6, tocilizumab (TCZ) (Actemra®), used clinically in rheumatoid arthritis (RA) would have similar anti-inflammatory effects in EAE after oral administration.B6 mice were immunized with MOG peptide 35 ...
Staley A, Brod, Victoria L, Bauer
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Proteases and Peptidases in EAE
2008The role of proteases and peptidases in the pathogenesis of EAE has been extensively studied. In particular research has focussed on the matrix metalloproteinase (MMP) family of enzymes as well the plasminogen activator/plasmin system. These enzymes have been proposed to have a number of functional roles in disease pathogenesis including: breakdown of ...
M Nicola Woodroofe, Rowena A D Bunning
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2008
Intramolecular and intermolecular epitope spreading, the development of immune cells with new reactivities different from the original immunodominant response, plays an important role in the relapses and progression of EAE and has been implicated in the progression of MS. This chapter describes the process of epitope spreading in EAE, its impact on the
Andrea E. Edling, Vincent K. Tuohy
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Intramolecular and intermolecular epitope spreading, the development of immune cells with new reactivities different from the original immunodominant response, plays an important role in the relapses and progression of EAE and has been implicated in the progression of MS. This chapter describes the process of epitope spreading in EAE, its impact on the
Andrea E. Edling, Vincent K. Tuohy
openaire +1 more source