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The effects of early-life and intergenerational stress on the brain
Proceedings of the Royal Society B: Biological Sciences, 2023Stress experienced during ontogeny can have profound effects on the adult phenotype. However, stress can also be experienced intergenerationally, where an offspring's phenotype can be moulded by stress experienced by the parents. Although early-life and intergenerational stress can alter anatomy, physiology, and behaviour, nothing is known
Lara D. LaDage +4 more
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Early life stress and susceptibility to addiction in adolescence
2021Early life stress (ELS) is a risk factor for developing a host of psychiatric disorders. Adolescence is a particularly vulnerable period for the onset of these disorders and substance use disorders (SUDs). Here we discuss ELS and its effects in adolescence, especially SUDs, and their correlates with molecular changes to signaling systems in reward and ...
K E, Tschetter +5 more
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Early life stress and metabolism
Current Opinion in Behavioral Sciences, 2019Exposure to stress is a normal and constant facet of life. However, excessive or chronic stress at particular phases of brain development can have lasting detrimental effects on many aspects of physiology, including appetite regulation and metabolism. A specific window of vulnerability to the lasting effects of stress is the early life period, in utero
Sajida Malik, Sarah J Spencer
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Stress gets into the belly: Early life stress and the gut microbiome
Behavioural Brain Research, 2021Research has established that stress "gets under the skin," impacting neuroendocrine and neuroimmune pathways to influence risk for physical and mental health outcomes. These effects can be particularly significant for early life stress (ELS), or adverse childhood experiences (ACEs). In this review, we explore whether stress gets "into the belly," that
Liisa Hantsoo, Babette S. Zemel
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Early life stress and cortisol: A meta-analysis
Hormones and Behavior, 2018Given the high prevalence of early life stress (ELS) and the potential physiological dysregulation such experiences can lead to, this meta-analysis tested the relationship between ELS and cortisol. Search terms related to ELS and cortisol were entered in to PsycINFO and PubMed. Effect sizes were extracted for four outcomes variables: cortisol awakening
Nia, Fogelman, Turhan, Canli
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Early life stress in depression susceptibility
Science, 2017Neurodevelopment The linkage between stress early in life and behavioral depression in adulthood is complex. Pena et al. were able to define a time period in early development when mice are especially susceptible to stress. Mice subjected to stress during this time period were less resilient to stress in adulthood.
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Plasticity of the epigenome during early-life stress
Seminars in Cell & Developmental Biology, 2018Early life adversity remains a significant risk factor for the development of a host of negative behavioural and pathological outcomes in adulthood long after the stressor is over. Recent evidence indicates that these lasting effects of ELS may occur via alterations in the epigenetic landscape.
Burns, S. Barnett +4 more
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Stress in early life inhibits neurogenesis in adulthood
Trends in Neurosciences, 2005Both structure and function of the hippocampus are altered by stress: by increasing levels of corticosteroids, stress causes atrophy of CA3 pyramidal cell dendrites, inhibits adult neurogenesis in the dentate gyrus, and impairs hippocampus-dependent learning.
Yashmin J G, Karten +2 more
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Early Life Stress and Psychopathology
2018Exposure to chronic or severe stressful life events during childhood and adolescence—frequently referred to as early life stress (ELS) or childhood adversity—has powerful and lasting associations with psychopathology across the life course. This chapter reviews the growing body of research on ELS and psychopathology across the life course, with a ...
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The Kindling/Sensitization Model and Early Life Stress
2020Few animal models address the characteristics of the longitudinal course of bipolar disorder. However, behavioral sensitization (to recurrent stressors and psychomotor stimulants) and kindling of seizures both provide clues to mechanisms in the progressive course of bipolar disorder.We describe aspects of bipolar illness that show sensitization and ...
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