Results 71 to 80 of about 5,362,575 (211)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Early onset sebaceous carcinoma

Diagnostic Pathology, 2011
Background Ocular sebaceous carcinoma can masquerade as benign lesions resulting in delay of diagnosis. Early recognition is even more difficult in young patients where the disease rarely occurs.
Kaltreider Sara A, Sung Dongjin, Gonzalez-Fernandez Federico   +2 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Service and support requirements of people with younger onset dementia and their families final report, August, 2012 [PDF]

, 2012
In 2011, Alzheimer’s Australia NSW (AlzNSW) was engaged by Ageing, Disability and Home Care (ADHC) to research the service and support requirements of people with younger onset dementia and their families in New South Wales.
Kylie Sait, Jo-Ann Brown
core  

Magnetic Controlled Growth Rods in the Treatment of Scoliosis: Safety, Efficacy and Patient Selection

Medical Devices: Evidence and Research, 2020
Athanasios I Tsirikos, Simon B Roberts Scottish National Spine Deformity Center, Royal Hospital for Sick Children, University of Edinburgh, Edinburgh, UKCorrespondence: Athanasios I TsirikosScottish National Spine Deformity Center, Royal Hospital for ...
Tsirikos AI, Roberts SB
doaj  

Early Onset Werner Syndrome

Endocrinology Research and Practice, 2015
Werner syndrome (WS) is a rare autosomal recessive adult-onset progeroid disorder characterized by the early onset of aged-appearance and age-related metabolic disorders.
Berna İmge AYDOĞAN, Uğur Ünlütürk, Mustafa ŞAHİN, Özgür Demir, Nilgün Başkal, Ali Rıza Uysal   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Early onset frontotermporal dementia and alzheimers disease: diagnosis, treatment and care [PDF]

, 2007
This research investigated two groups of patients diagnosed with dementia before the age of sixty-five. The patients were diagnosed with Alzheimer's Disease (AD, n = 25) and Frontotemporal Dementia (FTD, n = 37).
Rudge, John
core  

Maturity-Onset Diabetes of the Young Identified Among Algerian Probands with Early-Onset Diabetes

Diabetes, Metabolic Syndrome and Obesity, 2020
Faiza Bouldjennet,1,* Anette P Gjesing,2,* Malha Azzouz,3 Samir Ait Abderrahman,4 Amina El Guecier,5 Said Ali,6 Brahim Oudjit,4 Farida Mennadi-Lacete,7 Lyèce Yargui,6 Aissa Boudiba,3 Ahcène Chibane,5 Chafia Touil-Boukoffa,1 Torben Hansen,2 ...
Bouldjennet F, Gjesing AP, Azzouz M, Abderrahman SA, Guecier AE, Ali S, Oudjit B, Mennadi-Lacete F, Yargui L, Boudiba A, Chibane A, Touil-Boukoffa C, Hansen T, Raache R   +13 more
doaj  

Early Onset Absence Epilepsy

Pediatric Neurology Briefs, 2003
Neuropsychological evaluations, behavior patterns, and outcomes were studied in a retrospective analysis of 10 patients (7 girls, 3 boys) with onset of absence epilepsy before age 3 years, referred between 1986 and 2002 at Hopital Henri Gastaut ...
J Gordon Millichap
doaj   +1 more source