Results 51 to 60 of about 12,626,452 (304)

Early Childhood Education [PDF]

SSRN Electronic Journal, 2015
This paper organizes and synthesizes the literature on early childhood education and childcare. In it, we go beyond meta-analysis and reanalyze primary data sources in a common framework. We consider the evidence from means-tested demonstration programs, large-scale means-tested programs and universal programs without means testing.
Sneha Elango, Jorge Luis García, James J. Heckman, Andrés Hojman   +3 more
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

From family to school: the dual protection of father-child relationship and teacher-student relationship on children’s mental health problems

BMC Psychology
Mental health problems among children are a significant public health concern. Family dynamics and early educational environments are critical in shaping children’s mental health.
Youli Wang, Baocheng Pan, Honghuan Fang, Jingkai Sun, Bijing Ren, Ziyi Feng, Bowen Xiao, Pin Xu, Yan Li   +8 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Parental co-parenting quality, children’s emotion regulation abilities, and prosocial behavior

BMC Psychology
Objective This study used latent profile analysis to explore latent profiles of parental coparenting quality and their relationships with children’s prosocial behavior, and to examine the mediating role of children’s emotion regulation abilities. Methods
Baocheng Pan, Youli Wang, Jinghui Zhang, Jingyao Wang, Bowen Xiao, Yan Li   +5 more
doaj   +1 more source

Re-thinking pedagogies: New immigrants in Aotearoa New Zealand early childhood settings [PDF]

, 2014
This chapter examines the importance of teacher orientations towards immigrant children, families, and teachers in early childhood education settings in Aotearoa New Zealand.
Arndt, Sonja Kathrina, Arndt, Sonja
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Early Childhood Education

, 2020
Early Childhood Education (ECE) often is part of a broader educational disadvantage policy and offers institutionalcompensatory programs to young children who lack specific educational stimulation in the home environment. ECEtypically aims at children from deprived socioeconomic backgrounds and those of immigrant origin.
openaire   +3 more sources

The complex longitudinal influence of paternal and maternal parental psychological flexibility on child problem behavior: exploring the role of parenting styles

BMC Psychology
Purpose This study aims to explore the complex relationship between paternal and maternal parental psychological flexibility, parenting styles, and child problem behavior within the cultural context of China. Methods Structural equation modeling was used
Baocheng Pan, Youli Wang, Pin Xu, Yizhao Gong, Chengli Zhao, Jiaxuan Miao, Yan Li   +6 more
doaj   +1 more source

‘I prefer this because …’: Ecocentric and anthropocentric reasoning in Indonesian children’s pro-environmental attitudes

South African Journal of Childhood Education
Background: Early childhood is a crucial period during which attitudes and behaviours, including pro-environmental attitudes, begin to form. Understanding the reasons behind children’s environmental preferences is important because similar pro ...
Sitti H. Mas’ud, Fasli Jalal, Elindra Yetti   +2 more
doaj   +1 more source