Results 51 to 60 of about 1,236,768 (296)

Rhetoric to reality : early childhood education funding policy : a thesis in partial fulfilment of the requirements for the degree of Master of Arts in Social Policy at Massey University [PDF]

, 1999
In the 1997 budget the Government increased bulk funding to early childhood education centres by 5%. Since 1990 the amount of State spending on early childhood education has increased annually, more early childhood centres have opened and more children ...
Moss, Meg
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Relationship between static and dynamic balance in 4-to-5-year-old preschoolers: a cross-sectional study

BMC Pediatrics
Background Balance is crucial for physical development in preschool children. Exploring the relationship between different types of balance can help understand early physical development in children.
Ruqiang Liu, Juan Yang, Feifei Xi, Zichun Xu   +3 more
doaj   +1 more source

Cultural Cooking as Parenting Pedagogy: Strengthening Father–Child Attachment in Early Childhood Education

Al-Athfal: Jurnal Pendidikan Anak
Purpose – This study explores the effectiveness of fun cooking activities using Minangkabau traditional food as a culture-based pedagogical strategy to strengthen father–child attachment in early childhood education settings.
Vivi Anggraini, Rahmi Dwi Febriani, Ezi Anggraini, Adi Priyanto, Tia Novela, Yulsyofriend Yulsyofriend, Dwi Septia Ochi Wahyuni   +6 more
doaj   +1 more source

Early Developmental Activities and Computing Proficiency [PDF]

, 2018
As countries adopt computing education for all pupils from primary school upwards, there are challenging indicators: significant proportions of students who choose to study computing at universities fail the introductory courses, and the evidence for ...
Alshaigy, Bedour, Cole, Elizabeth, Cutts, Quintin, Donaldson, Peter, Gutica, Mirela, Hellas, Arto, Larraza-Mendiluze, Edurne, McCartney, Robert, Patitsas, Elizabeth, Riedesel, Charles   +9 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Parenting Research in Indonesia: What We Have Done So Far

Buletin Psikologi, 2020
Parenting is one of the most important responsibilities that someone could bear as a parent, probably the most burdensome too. Regardless, several questions are still left unanswered by Indonesian scientists, what are the field of studies related to ...
Beatriks Novianti Kiling-Bunga, Kristin Margiani, Indra Yohanes Kiling   +2 more
doaj   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source