Results 51 to 60 of about 320,843 (308)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

From family to school: the dual protection of father-child relationship and teacher-student relationship on children’s mental health problems

BMC Psychology
Mental health problems among children are a significant public health concern. Family dynamics and early educational environments are critical in shaping children’s mental health.
Youli Wang, Baocheng Pan, Honghuan Fang, Jingkai Sun, Bijing Ren, Ziyi Feng, Bowen Xiao, Pin Xu, Yan Li   +8 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Parental co-parenting quality, children’s emotion regulation abilities, and prosocial behavior

BMC Psychology
Objective This study used latent profile analysis to explore latent profiles of parental coparenting quality and their relationships with children’s prosocial behavior, and to examine the mediating role of children’s emotion regulation abilities. Methods
Baocheng Pan, Youli Wang, Jinghui Zhang, Jingyao Wang, Bowen Xiao, Yan Li   +5 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

The complex longitudinal influence of paternal and maternal parental psychological flexibility on child problem behavior: exploring the role of parenting styles

BMC Psychology
Purpose This study aims to explore the complex relationship between paternal and maternal parental psychological flexibility, parenting styles, and child problem behavior within the cultural context of China. Methods Structural equation modeling was used
Baocheng Pan, Youli Wang, Pin Xu, Yizhao Gong, Chengli Zhao, Jiaxuan Miao, Yan Li   +6 more
doaj   +1 more source

A Systematic Scoping Review on the Transition of Under-3-Year-Old Children from Home to Early Childhood Education and Care

Education Sciences
This systematic scoping review aimed to identify and describe published peer-reviewed research articles on the transition of under-3-year-old children from home to early childhood education and care (ECEC) from 1 January 2013 to 19 August 2024.
Catharina Petronella Johanna van Trijp, Marianne Ree, Tove Erna Belland, Sara Esmaeeli, Gunnar Magnus Eidsvåg, Mariella Annika Asikanius, Lars Yngve Rosell   +6 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Maternal distress, parenting stress, maladaptive parenting and children’s problematic media use in China: evidence from 2022 spring in Shanghai

BMC Public Health
The COVID-19 lockdown has forced young children to spend more time on media and significantly impacted their mothers’ mental health. This study explored how mothers’ individual distress influences children’s problematic media use during the Shanghai ...
Jingyao Wang, Shumin Wang, Bowen Xiao, Juan Li, Yuemin Feng, Yan Li   +5 more
doaj   +1 more source