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Early detection of ovarian cancer [PDF]
CA: A Cancer Journal for Clinicians, 1995 Ovarian cancer meets the criteria of a disease for which screening can be justified. The disease is most often diagnosed in advanced stages, when chances for long-term survival are poor. Yet effective treatment exists for early-stage disease, such that early detection can increase long-term survival.
Michael Teneriello, R. C. Park
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Early Detection of Ovarian Cancer [PDF]
Biomarkers in Medicine, 2008 Ovarian cancer is associated with an overall mortality of 75%, but can be cured in up to 90% of cases if diagnosed while still limited to the ovaries. Given the low prevalence of ovarian cancer in the general population, an effective screening strategy must not only have a high sensitivity for early-stage disease (>75%), but must also have a very high ...
Partha M, Das, Robert C, Bast
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Epigenetic loss of heterogeneity from low to high grade localized prostate tumours
Nature Communications, 2021 High tumour heterogeneity hinders the identification of molecular subtypes in prostate cancer. Here, the authors integrate single-cell chromatin accessibility data with multiplex imaging and reveal distinct chromatin features and transcriptional factor ...
Sebnem Ece Eksi +7 more
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Communications Biology, 2021 Montoya Mira & Sapre et al. design a microfluidic device utilizing dielectrophoresis for the enrichment of circulating neoplastic cells that possess both epithelial and immune-like characteristics. They optimized the device using in vitro models and then
Jose Montoya Mira +9 more
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Science, 2022 Survival improves when cancer is detected early. However, ~50% of cancers are at an advanced stage when diagnosed. Early detection of cancer or precancerous change allows early intervention to try to slow or prevent cancer development and lethality. To achieve early detection of all cancers, numerous challenges must be overcome.
Crosby, David +11 more
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Selective enrichment of plasma cell-free messenger RNA in cancer-associated extracellular vesicles
Communications Biology, 2023 Extracellular vesicles (EVs) have been shown as key mediators of extracellular small RNA transport. However, carriers of cell-free messenger RNA (cf-mRNA) in human biofluids and their association with cancer remain poorly understood. Here, we performed a
Hyun Ji Kim +12 more
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npj Precision Oncology, 2022 Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of cancer and the systemic host response. Here we report that cfRNA sequencing enables the discovery of messenger RNA (mRNA) biomarkers in plasma with the tissue of ...
Breeshey Roskams-Hieter +12 more
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World Journal of Surgical Oncology, 2023 Background The number of patients with non-palpable breast lesions has increased gradually. This is because of the technological development in imaging techniques and the screening programs that lead to early detection of breast lesions.
Yasmine hany elzohery +5 more
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Oncogene-mediated metabolic gene signature predicts breast cancer outcome
npj Breast Cancer, 2021 Breast cancer remains the second most lethal cancer among women in the United States and triple-negative breast cancer is the most aggressive subtype with limited treatment options.
Merve Aslan +13 more
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The Egyptian Journal of Radiology and Nuclear Medicine, 2021 Background Breast microcalcifications are one of the most difficult mammographic findings to assess. The purpose of this study is to assess the ability of contrast-enhanced spectral mammography in the assessment of suspicious microcalcification and in ...
Ola Magdy Mohamed Shetat +5 more
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