Results 11 to 20 of about 813,162 (218)

Epigenetic loss of heterogeneity from low to high grade localized prostate tumours

Nature Communications, 2021
High tumour heterogeneity hinders the identification of molecular subtypes in prostate cancer. Here, the authors integrate single-cell chromatin accessibility data with multiplex imaging and reveal distinct chromatin features and transcriptional factor ...
Sebnem Ece Eksi, Alex Chitsazan, Zeynep Sayar, George V. Thomas, Andrew J. Fields, Ryan P. Kopp, Paul T. Spellman, Andrew C. Adey   +7 more
doaj   +1 more source

Label-free enrichment of rare unconventional circulating neoplastic cells using a microfluidic dielectrophoretic sorting device

Communications Biology, 2021
Montoya Mira & Sapre et al. design a microfluidic device utilizing dielectrophoresis for the enrichment of circulating neoplastic cells that possess both epithelial and immune-like characteristics. They optimized the device using in vitro models and then
Jose Montoya Mira, Ajay A. Sapre, Brett S. Walker, Jesus Bueno Alvarez, Kyle T. Gustafson, Eugene Tu, Jared M. Fischer, Melissa H. Wong, Sadik Esener, Yu-Jui Chiu   +9 more
doaj   +1 more source

Selective enrichment of plasma cell-free messenger RNA in cancer-associated extracellular vesicles

Communications Biology, 2023
Extracellular vesicles (EVs) have been shown as key mediators of extracellular small RNA transport. However, carriers of cell-free messenger RNA (cf-mRNA) in human biofluids and their association with cancer remain poorly understood. Here, we performed a
Hyun Ji Kim, Matthew J. Rames, Florian Goncalves, C. Ward Kirschbaum, Breeshey Roskams-Hieter, Elias Spiliotopoulos, Josephine Briand, Aaron Doe, Joseph Estabrook, Josiah T. Wagner, Emek Demir, Gordon Mills, Thuy T. M. Ngo   +12 more
doaj   +1 more source

Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies

npj Precision Oncology, 2022
Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of cancer and the systemic host response. Here we report that cfRNA sequencing enables the discovery of messenger RNA (mRNA) biomarkers in plasma with the tissue of ...
Breeshey Roskams-Hieter, Hyun Ji Kim, Pavana Anur, Josiah T. Wagner, Rowan Callahan, Elias Spiliotopoulos, Charles Ward Kirschbaum, Fehmi Civitci, Paul T. Spellman, Reid F. Thompson, Khashayar Farsad, Willscott E. Naugler, Thuy T. M. Ngo   +12 more
doaj   +1 more source

Comparison of wire-guided localization (WGL) and radio-guided occult lesion localization (ROLL) in localization of non-palpable breast lesions

World Journal of Surgical Oncology, 2023
Background The number of patients with non-palpable breast lesions has increased gradually. This is because of the technological development in imaging techniques and the screening programs that lead to early detection of breast lesions.
Yasmine hany elzohery, Mohammed Mohammed Gomaa, Ghada Mohamed, Waleed Mohamed Fadlalla, Sherif Nasser Taha, Maher H. Ibraheem   +5 more
doaj   +1 more source

Oncogene-mediated metabolic gene signature predicts breast cancer outcome

npj Breast Cancer, 2021
Breast cancer remains the second most lethal cancer among women in the United States and triple-negative breast cancer is the most aggressive subtype with limited treatment options.
Merve Aslan, En-Chi Hsu, Fernando J. Garcia-Marques, Abel Bermudez, Shiqin Liu, Michelle Shen, Meredith West, Chiyuan Amy Zhang, Meghan A. Rice, James D. Brooks, Robert West, Sharon J. Pitteri, Balázs Győrffy, Tanya Stoyanova   +13 more
doaj   +1 more source

Added value of contrast-enhanced spectral mammogram in assessment of suspicious microcalcification and grading of DCIS

The Egyptian Journal of Radiology and Nuclear Medicine, 2021
Background Breast microcalcifications are one of the most difficult mammographic findings to assess. The purpose of this study is to assess the ability of contrast-enhanced spectral mammography in the assessment of suspicious microcalcification and in ...
Ola Magdy Mohamed Shetat, Amr Farouk Ibrahim Moustafa, Sara Zaitoon, Mohamed Ibrahim Ibrahim Fahim, Ghada Mohamed, Mohammed Mohammed Gomaa   +5 more
doaj   +1 more source

Irreversible alteration of extracellular vesicle and cell-free messenger RNA profiles in human plasma associated with blood processing and storage

Scientific Reports, 2022
The discovery and utility of clinically relevant circulating biomarkers depend on standardized methods that minimize preanalytical errors. Despite growing interest in studying extracellular vesicles (EVs) and cell-free messenger RNA (cf-mRNA) as ...
Hyun Ji Kim, Matthew J. Rames, Samuel Tassi Yunga, Randall Armstrong, Mayu Morita, Anh T. P. Ngo, Owen J. T. McCarty, Fehmi Civitci, Terry K. Morgan, Thuy T. M. Ngo   +9 more
doaj   +1 more source

The added role of contrast-enhanced spectral mammography in the evaluation of pathological nipple discharge

The Egyptian Journal of Radiology and Nuclear Medicine, 2022
Background Nipple discharge is one of the commonest encountered complaints in the field of breast imaging. Excluding malignancy as a cause of pathological nipple discharge is of utmost importance.
Sherihan Fakhry, Rasha Wessam Abdel Rahman, Hanan Shawky Shaalan, Maher Hassan Ibraheem Hassan, Safy Hosny Tealab, Safia Badr Sayed   +5 more
doaj   +1 more source

The value of ultrasound to differentiate between benign and malignant duct ectasia

مجلة كلية الطب, 2014
Background: Mammary duct ectasia is defined as dilated duct larger than 2 mm in diameter seen in fibrocystic changes, ductal epithelial hyperplasia, papiloma, DCIS. US has a significant role in diagnostic breast imaging.
Enam A. AL -Tememy, Laith Ahmad, Zainab O. AL-Shaheen, Jinan A. Jabbar   +3 more
doaj   +1 more source