Results 41 to 50 of about 813,162 (218)

Cell free RNA detection of pancreatic cancer in pre diagnostic high risk and symptomatic patients

Nature Communications
Pancreatic ductal adenocarcinomas (PDAC) are among the most fatal cancers, in part due to frequent detection at advanced stages. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA), the most sensitive diagnostic method of PDAC in current ...
Travis W. Moore, Elias Spiliotopoulos, Rowan L. Callahan, C. Ward Kirschbaum, Conner F. Bailey, Hyun Ji Kim, Breeshey Roskams-Hieter, Florian Goncalves, Dove Keith, Aaron J. Grossberg, Paul T. Spellman, Gordon B. Mills, Rosalie C. Sears, Terry K. Morgan, Thuy T. M. Ngo   +14 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Multi-detector CT chest: can it omit the further need for contrast enhnaced spectral mammography in breast cancer patients candidate for CT staging?

The Egyptian Journal of Radiology and Nuclear Medicine, 2022
Background During multi-detector computed tomography (MDCT) of the chest, incidental breast lesions (IBLs) are occasionally encountered. Mammography remains the gold standard for the early detection of breast cancer.
Rasha Wessam Abdel Rahman, Salwa Yahya Ahmed Al-Dhurani, Amira Hamed Radwan, Ahmed Abdellatif Mohamed, Eman Faker Kamal   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Identification and characterization of intact glycopeptides in human urine

Scientific Reports
Glycoproteins in urine have the potential to provide a rich class of informative molecules for studying human health and disease. Despite this promise, the urine glycoproteome has been largely uncharacterized.
Fernando Garcia-Marques, Keely Fuller, Abel Bermudez, Nikhiya Shamsher, Hongjuan Zhao, James D. Brooks, Mark R. Flory, Sharon J. Pitteri   +7 more
doaj   +1 more source

Building Multi-Marker Algorithms for Disease Prediction–-The Role of Correlations among Markers

Biomarker Insights, 2011
A widely held viewpoint in the field of predictive biomarkers for disease holds that no single marker can provide high enough discrimination and that a panel of markers, combined in some type of algorithm, will be needed.
Paul F. Pinsky, Claire S. Zhu
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

IMMUNOREGULATION OF INTERLEUKIN-2 BY GLUCOCORTICOIDS AND THEIR EFFECT ON MITOGEN INDUCED PERIPHERAL BLOOD LYMPHOCYTE TRANSFORMATION IN ADULT MALE RATS [PDF]

Veterinary Medical Journal - Giza, 1999
Adult male rats were subcutaneously injected with dexamethasone at a dose of 1mg/kg B.w. for five doses. Another group of adult male rats were subjected to elevated ambient temperature and relative humidity for two and four days.
Y HUSSEIN, MONA ABDEL-HADY, H EL-BELBASI
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source