Results 1 to 10 of about 1,060,327 (130)

Krüppel-Like Factor 12 Promotes Colorectal Cancer Growth through Early Growth Response Protein 1. [PDF]

PLoS ONE, 2016
Krüppel-like factor 12 (KLF12) is a transcription factor that plays a role in normal kidney development and repression of decidualization. KLF12 is frequently elevated in esophageal adenocarcinoma and has been reported to promote gastric cancer ...
Sun-Hee Kim, Yun-Yong Park, Sung-Nam Cho, Ofer Margalit, Dingzhi Wang, Raymond N DuBois   +5 more
doaj   +6 more sources

Early Growth Response Protein 1 Exacerbates Murine Inflammatory Bowel Disease by Transcriptional Activation of Matrix Metalloproteinase 12 [PDF]

Biomedicines
Inflammatory bowel disease (IBD) is an inflammatory condition affecting the colon and small intestine, with Crohn’s disease and ulcerative colitis being the major types.
Shih-Yao Chen, Chuan-Yin Fang, Bing-Hwa Su, Hao-Ming Chen, Shih-Chi Huang, Po-Ting Wu, Ai-Li Shiau, Chao-Liang Wu   +7 more
doaj   +4 more sources

Human Immunodeficiency Virus-1 Latency Reversal via the Induction of Early Growth Response Protein 1 to Bypass Protein Kinase C Agonist-Associated Immune Activation [PDF]

Frontiers in Microbiology, 2022
Human Immunodeficiency Virus-1 (HIV) remains a global health challenge due to the latent HIV reservoirs in people living with HIV (PLWH). Dormant yet replication competent HIV harbored in the resting CD4+ T cells cannot be purged by antiretroviral ...
Lilly M. Wong, Dajiang Li, Yuyang Tang, Gema Méndez-Lagares, George R. Thompson, Dennis J. Hartigan-O’Connor, Satya Dandekar, Guochun Jiang, Guochun Jiang   +8 more
doaj   +2 more sources

Stimulation of the human CTP:phosphoethanolamine cytidylyltransferase gene by early growth response protein 1 [PDF]

Journal of Lipid Research, 2008
Change in phosphoethanolamine pool size in tumor tissues is an important indicator of tumor prognosis and drug therapy efficacy. Phosphoethanolamine is the substrate of the regulatory enzyme CTP:phosphoethanolamine cytidylyltransferase (ECT) in the de ...
Lin Zhu, Christa Johnson, Marica Bakovic
doaj   +3 more sources

Regulation of early growth response 2 expression by secreted frizzled related protein 1 [PDF]

BMC Cancer, 2017
Background Secreted frizzled-related protein 1 (SFRP1) expression is down-regulated in a multitude of cancers, including breast cancer. Loss of Sfrp1 also exacerbates weight gain as well as inflammation.
Kelly J. Gregory, Stephanie M. Morin, Sallie S. Schneider   +2 more
doaj   +3 more sources

HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling. [PDF]

Oncotarget, 2017
Human T cell leukemia virus type 1 (HTLV-1) is a complex retrovirus that causes adult T cell leukemia (ATL) in susceptible individuals. The HTLV-1-encoded oncoprotein Tax induces persistent activation of the nuclear factor-κB (NF-κB) pathway. Early growth response protein 1 (EGR1) is overexpressed in HTLV-1-infected T cell lines and ATL cells. Here, we
Huang Q, Niu Z, Han J, Liu X, Lv Z, Li H, Yuan L, Li X, Sun S, Wang H, Huang X.   +10 more
europepmc   +4 more sources

Early growth response protein 1 promotes restenosis by upregulating intercellular adhesion molecule-1 in vein graft. [PDF]

Oxid Med Cell Longev, 2013
To verify the relationship between Egr-1 and vein graft restenosis and investigate the related mechanisms.Mouse vein graft models were established in Egr-1 knockout (KO) and wild-type (WT) mice. The vein grafts in the mice were taken for pathological examination and immunohistochemical analysis.
Zhang K, Cao J, Dong R, Du J.
europepmc   +3 more sources

Early growth response protein 1 and dual specificity protein phosphatase 1 are involved in down-regulation of allergic responses [PDF]

Clin Transl Allergy, 2013
Background The airway epithelium is accepted as an active player in immune responses. Besides its role as physical barrier towards invading pathogens and irritants, epithelium also affects the outcome of the immune response by the production of various pro-inflammatory mediators.
Golebski K, van Egmond D, de Groot E, Fokkens W, van Drunen C.   +4 more
europepmc   +3 more sources

Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells [PDF]

Biomolecules, 2015
The RNA-binding protein tristetraprolin (TTP) promotes rapid decay of mRNAs bearing 3' UTR AU-rich elements (ARE). In many cancer types, loss of TTP expression is observed allowing for stabilization of ARE-mRNAs and their pathologic overexpression.
Cyril Sobolewski, Sandhya Sanduja, Fernando F. Blanco, Liangyan Hu, Dan A. Dixon   +4 more
doaj   +2 more sources

Heparin inhibits Hepatocyte Growth Factor induced motility and invasion of hepatocellular carcinoma cells through early growth response protein 1. [PDF]

PLoS ONE, 2012
The Hepatocyte Growth Factor (HGF)/c-Met signaling pathway regulates hepatocyte proliferation, and pathway aberrations are implicated in the invasive and metastatic behaviors of hepatocellular carcinoma (HCC).
Evin Ozen, Aysim Gozukizil, Esra Erdal, Aykut Uren, Donald P Bottaro, Nese Atabey   +5 more
doaj   +7 more sources