Results 11 to 20 of about 1,060,446 (249)

Androgen receptor dampens tissue factor expression via nuclear factor-κB and early growth response protein 1. [PDF]

J Thromb Haemost, 2018
Essentials Androgen deprivation increases the rate of venous thromboembolism in prostate cancer patients. We characterized androgen receptor-mediated tissue factor regulation in prostate epithelial cells. Androgen receptor is dampening tissue factor expression in prostate epithelial cells. Androgen deprivation could enhance tissue factor expression and
Hoesel B, Mussbacher M, Dikorman B, Salzmann M, Assinger A, Hell L, Thaler J, Basílio J, Moser B, Resch U, Paar H, Mackman N, Schmid JA.   +12 more
europepmc   +4 more sources

Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity.

Am J Physiol Endocrinol Metab, 2013
Obesity is associated with low-grade chronic inflammation, which contributes to cellular dysfunction promoting metabolic disease. Obesity during pregnancy leads to a proinflammatory milieu in the placenta; however, the underlying causes for obesity-induced placental inflammation remain unclear.
Saben J, Zhong Y, Gomez-Acevedo H, Thakali KM, Borengasser SJ, Andres A, Shankar K.   +6 more
europepmc   +4 more sources

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0 [PDF]

Journal of Neuroinflammation, 2019
Background Herpes simplex virus-1 (HSV-1) infections of the central nervous system (CNS) can result in HSV-1 encephalitis (HSE) which is characterized by severe brain damage and long-term disabilities.
Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus   +17 more
doaj   +5 more sources

Corrigendum to "Early Growth Response Protein 1 Promotes Restenosis by Upregulating Intercellular Adhesion Molecule-1 in Vein Graft". [PDF]

Oxid Med Cell Longev, 2021
Zhang K, Cao J, Dong R, Du J.
europepmc   +3 more sources

GnRH Regulates Early Growth Response Protein 1 Transcription Through Multiple Promoter Elements [PDF]

Molecular Endocrinology, 2002
Pulsatile secretion of GnRH is the major regulator of gonadotropin (LH, FSH) gene expression and secretion. Recently, GnRH has been shown to rapidly stimulate the expression of early growth response protein-1 (Egr-1), a transcription factor that is essential for LHbeta gene expression in the pituitary. In this study, we examined the regulatory elements
W Rachel, Duan, Masafumi, Ito, Youngkyu, Park, Evelyn T, Maizels, Mary, Hunzicker-Dunn, J Larry, Jameson   +5 more
openaire   +3 more sources

Acute psilocybin increased cortical activities in rats

Frontiers in Neuroscience, 2023
Psilocybin, a naturally occurring hallucinogenic component of magic mushrooms, has significant psychoactive effects in both humans and rodents. But the underlying mechanisms are not fully understood.
Junhong Liu, Yuanyuan Wang, Yuanyuan Wang, Ke Xia, Jinfeng Wu, Danhao Zheng, Aoling Cai, Haitao Yan, Ruibin Su   +8 more
doaj   +1 more source

Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth [PDF]

Cancer Research, 2006
Abstract Transient induction of the transcription factor early growth response protein-1 (EGR-1) plays a pivotal role in the transcriptional response of endothelial cells to the angiogenic growth factors vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), which are produced by most tumors and are ...
Markus, Lucerna, Jiri, Pomyje, Diana, Mechtcheriakova, Alexandra, Kadl, Florian, Gruber, Martin, Bilban, Yuri, Sobanov, Gernot, Schabbauer, Johannes, Breuss, Oswald, Wagner, Markus, Bischoff, Matthias, Clauss, Bernd R, Binder, Erhard, Hofer   +13 more
openaire   +2 more sources

Examining the role of EGR1 during viral infections

Frontiers in Microbiology, 2022
Early growth response 1 (EGR1) is a multifunctional mammalian transcription factor capable of both enhancing and/or inhibiting gene expression. EGR1 can be activated by a wide array of stimuli such as exposure to growth factors, cytokines, apoptosis, and
Caitlin M. Woodson, Caitlin M. Woodson, Kylene Kehn-Hall, Kylene Kehn-Hall   +3 more
doaj   +1 more source

Early growth response protein 1 acts as an activator of SOX18 promoter [PDF]

Experimental and Molecular Medicine, 2010
Sex-determining region Y box 18 (Sox18/SOX18) gene is an important regulator of vascular development playing a role in endothelial cell specification or differentiation, angiogenesis and atherogenesis. The aim of this study was to perform comprehensive functional characterization of the human SOX18 promoter, including determination of transcription ...
Petrović, Isidora, Kovačević Grujičić, Nataša, Stevanović, Milena   +2 more
openaire   +3 more sources

WNT11 is a direct target of early growth response protein 1

BMB Reports, 2020
WNT11 is a member of the non-canonical Wnt family and plays a crucial role in tumor progression. However, the regulatory mechanisms underlying WNT11 expression are unclear. Tumor necrosis factor-alpha (TNFα) is a major inflammatory cytokine produced in the tumor microenvironment and contributes to processes associated with tumor progression, such as ...
Kim, JuHwan, Jung, Euitaek, Ahn, Sung Shin, Yeo, Hyunjin, Lee, Jeong Yeon, Seo, Jeong Kon, Lee, Young Han, Shin, Soon Young   +7 more
openaire   +4 more sources