Results 21 to 30 of about 1,060,446 (249)

Epigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy

Redox Biology, 2021
S-adenosylhomocysteine (SAH) is hydrolyzed by SAH hydrolase (SAHH) to homocysteine and adenosine. Increased plasma SAH levels were associated with disturbed renal function in patients with diabetes.
Xin Dai, Ruyi Liao, Chaoqun Liu, Si Liu, Haiyan Huang, Jianjun Liu, Tianru Jin, Honghui Guo, Zhihua Zheng, Min Xia, Wenhua Ling, Yunjun Xiao   +11 more
doaj   +1 more source

Helicobacter pyloriActivates the Early Growth Response 1 Protein in Gastric Epithelial Cells [PDF]

Infection and Immunity, 2004
ABSTRACTThe early growth response 1 (Egr-1) transcription factor is rapidly induced by various stimuli and is implicated in the regulation of cell growth, differentiation, and gene expression. The aim of this study was to examine the effect ofHelicobacter pylorion the expression of Egr-1 and Egr-1-regulated genes in gastric epithelial AGS cells.
Abdel-Latif, M.M.M., Windle, H. J., Fitzgerald, Katherine A, Ang, Y. S., Eidhin, D. Ni, Li-Weber, M., Sabra, K., Kelleher, Daniel J.   +7 more
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Protein Kinase C β/Early Growth Response-1 Pathway

Journal of the American College of Cardiology, 2006
Atherosclerosis, restenosis, and the consequences of ischemia are the major causes of morbidity and mortality worldwide. Elucidation of key contributing pathways in animal models of ischemia-reperfusion injury, atherosclerosis, and restenosis consequent to vascular injury may lead to great interest in determining if blocking these pathways could ...
Yan, Shi-Fang, Harja, Evis, Andrassy, Martin, Fujita, Tomoyuki, Schmidt, Ann Marie   +4 more
openaire   +3 more sources

MicroRNAs as novel peripheral markers for suicidality in patients with major depressive disorder

Frontiers in Psychiatry, 2022
ObjectiveMajor depressive disorder (MDD) constitutes a main risk factor for suicide. Suicide risk in psychiatric patients is primarily determined by often unreliable, self-reported information.
Britta Stapel, Ke Xiao, Ke Xiao, Nataliya Gorinski, Kevin Schmidt, Angelika Pfanne, Jan Fiedler, Jan Fiedler, Imke Richter, Anna-Lena Vollbrecht, Thomas Thum, Thomas Thum, Thomas Thum, Kai G. Kahl, Evgeni Ponimaskin   +14 more
doaj   +1 more source

Early Growth Response 1 (Egr-1) Regulates Phosphorylation of Microtubule-associated Protein Tau in Mammalian Brain [PDF]

Journal of Biological Chemistry, 2011
In the normal brain, tau protein is phosphorylated at a number of proline- and non-proline directed sites, which reduce tau microtubule binding and thus regulate microtubule dynamics. In Alzheimer disease (AD), tau is abnormally hyperphosphorylated, leading to neurofibrillary tangle formation and microtubule disruption, suggesting a loss of regulatory ...
Yifan, Lu, Tong, Li, Hamid Y, Qureshi, Dong, Han, Hemant K, Paudel   +4 more
openaire   +2 more sources

Early Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Early growth response‐1 (Egr‐1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our understanding of the regulatory roles this zinc finger protein and product of an ...
Levon M. Khachigian
doaj   +1 more source

Data from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth

, 2023
<div>Abstract<p>Transient induction of the transcription factor early growth response protein-1 (EGR-1) plays a pivotal role in the transcriptional response of endothelial cells to the angiogenic growth factors vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), which are produced by most tumors and are ...
Erhard Hofer, Bernd R. Binder, Matthias Clauss, Markus Bischoff, Oswald Wagner, Johannes Breuss, Gernot Schabbauer, Yuri Sobanov, Martin Bilban, Florian Gruber, Alexandra Kadl, Diana Mechtcheriakova, Jiri Pomyje, Markus Lucerna   +13 more
openaire   +1 more source

Retrieval of Consolidated Spatial Memory in the Water Maze Is Correlated with Expression of pCREB and Egr1 in the Hippocampus of Aged Mice

Dementia and Geriatric Cognitive Disorders Extra, 2013
Objective: To study the relationship of the expression of phosphorylated cyclic AMP response element-binding protein (pCREB) and early growth response protein 1 (Egr1) in the hippocampus of aged mice with retrieval of consolidated spatial memory in a ...
GuoXia Zhou, WanXia Xiong, XiaoGuang Zhang, ShengJin Ge   +3 more
doaj   +1 more source

miR-377-3p-Mediated EGR1 Downregulation Promotes B[a]P-Induced Lung Tumorigenesis by Wnt/Beta-Catenin Transduction

Frontiers in Oncology, 2021
Polycyclic aromatic hydrocarbons (PAHs), particularly benzo[a]pyrene (B[a]P), found in cigarette smoke and air pollution, is an important carcinogen.
Xinxin Ke, Lulu He, Runan Wang, Jing Shen, Zhengyang Wang, Yifei Shen, Longjiang Fan, Jimin Shao, Jimin Shao, Hongyan Qi   +9 more
doaj   +1 more source

cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1) [PDF]

Biochemical Journal, 1998
Egr-1 (early-growth response factor-1) is a sequence-specific transcription factor that plays a regulatory role in the expression of many genes important for cell growth, development and the pathogenesis of disease. The transcriptional co-activators CBP (cAMP-response-element-binding-protein-binding protein) and p300 interact with sequence-specific ...
E S, Silverman, J, Du, A J, Williams, R, Wadgaonkar, J M, Drazen, T, Collins   +5 more
openaire   +2 more sources