Results 31 to 40 of about 1,060,446 (249)

T-cell activation and early gene response in dogs. [PDF]

PLoS ONE, 2015
T-cells play a crucial role in canine immunoregulation and defence against invading pathogens. Proliferation is fundamental to T-cell differentiation, homeostasis and immune response.
Sally-Anne Mortlock, Jerry Wei, Peter Williamson   +2 more
doaj   +1 more source

Ring finger protein 2 promotes colorectal cancer progression by suppressing early growth response 1

Aging, 2020
Ring finger protein 2 (RNF2) is an important component of polycomb repressive complex 1. RNF2 is upregulated in many kinds of tumors, and elevated RNF2 expression is associated with a poor prognosis in certain cancers. To assess the function of RNF2 in colorectal cancer, we examined RNF2 protein levels in 313 paired colorectal cancer tissues and ...
Wei, Feilong, Jing, Haoren, Wei, Ming, Liu, Lei, Wu, Jieheng, Wang, Meng, Han, Donghui, Yang, Fa, Yang, Bo, Jiao, Dian, Zheng, Guoxu, Zhang, Lingling, Xi, Wenjin, Guo, Zhangyan, Yang, An-Gang, Qin, Weijun, Zhou, Yi, Wen, Weihong   +17 more
openaire   +2 more sources

Proline-rich protein 11 overexpression is associated with a more aggressive phenotype and poor overall survival in ovarian cancer patients

World Journal of Surgical Oncology, 2020
Background The proline-rich protein 11 (PRR11) is a newly identified oncogene associated with a poor prognosis in several human cancers. Nonetheless, research on its role in ovarian cancer (OC) remains largely understudied.
Yu Zhan, Xueyuan Wu, Gang Zheng, Jingjing Jin, Chaofu Li, Guanzhen Yu, Wenfeng Li   +6 more
doaj   +1 more source

MiR-551b-5p Contributes to Pathogenesis of Vein Graft Failure via Upregulating Early Growth Response-1 Expression

Chinese Medical Journal, 2017
Background: Vein graft failure (VGF) is a serious complication of coronary artery bypass graft, although the mechanism remains unclear. The study aimed to investigate the effects of microRNAs (miRNAs) on the endothelial dysfunction involved in VGF ...
Ran Dong, Kui Zhang, Yue-Li Wang, Feng Zhang, Jian Cao, Ju-Bing Zheng, Hong-Jia Zhang   +6 more
doaj   +1 more source

pH modulates the binding of early growth response protein 1 transcription factor to DNA [PDF]

The FEBS Journal, 2013
The transcription factor early growth response protein (EGR)1 orchestrates a plethora of signaling cascades involved in cellular homeostasis, and its downregulation has been implicated in the development of prostate cancer. Herein, using a battery of biophysical tools, we show that the binding of EGR1 to DNA is tightly regulated by solution pH ...
David C, Mikles, Vikas, Bhat, Brett J, Schuchardt, Brian J, Deegan, Kenneth L, Seldeen, Caleb B, McDonald, Amjad, Farooq   +6 more
openaire   +2 more sources

Desmin Regulates Airway Smooth Muscle Hypertrophy through Early Growth-responsive Protein-1 and MicroRNA-26a [PDF]

Journal of Biological Chemistry, 2011
Bronchial biopsies of asthmatic patients show a negative correlation desmin expression in airway smooth muscle cell (ASMC) and airway hyperresponsiveness. We previously showed that desmin is an intracellular load-bearing protein, which influences airway compliance, lung recoil, and airway contractile responsiveness (Shardonofsky, F. R., Capetanaki, Y.,
Junaith S, Mohamed, Ameena, Hajira, Zhenlin, Li, Denise, Paulin, Aladin M, Boriek   +4 more
openaire   +2 more sources

Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

mSphere, 2020
Regulation of epidermal growth factor (EGF) receptor (EGFR) signaling is critical for the replication of human cytomegalovirus (HCMV) as well as latency and reactivation in CD34+ hematopoietic progenitor cells.
Meaghan H. Hancock, Jennifer Mitchell, Felicia D. Goodrum, Jay A. Nelson   +3 more
doaj   +3 more sources

UDP-N-Acetylglucosamine Pyrophosphorylase 2 (UAP2) and 1 (UAP1) Perform Synergetic Functions for Leaf Survival in Rice

Frontiers in Plant Science, 2021
Functional inactivation of UDP-N-acetylglucosamine pyrophosphorylase 1 (UAP1) induces defense response-related lesion-mimic spots and subsequent early senescence in every newly grown leaf of the rice mutant uap1 after a short period's normal growth ...
Zhaohai Wang, Zhaohai Wang, Qiang Wang, Qiang Wang, Lingxia Wei, Lingxia Wei, Yan Shi, Yan Shi, Ting Li, KeKe Hu, Shuai Liu, Hua Zhong, Jianglin Liao, Jianglin Liao, Yangsheng Li, Hongyu Zhang, Yingjin Huang, Yingjin Huang   +17 more
doaj   +1 more source

Expression of immediate-early genes in the inferior colliculus and auditory cortex in salicylate-induced tinnitus in rat

European Journal of Histochemistry, 2014
Tinnitus could be associated with neuronal hyperactivity in the auditory center. As a neuronal activity marker, immediate-early gene (IEG) expression is considered part of a general neuronal response to natural stimuli. Some IEGs, especially the activity-
S.S. Hu, L. Mei, J.Y. Chen, Z.W. Huang, H. Wu   +4 more
doaj   +1 more source

HMGA1/SMAD3 Promoter Complex Mediates PD-L1-Dependent Transcriptional Regulation of GAS6, EGR1 and PD-L1

Frontiers in Bioscience-Landmark
Background: Programmed death-ligand 1 (PD-L1) partners with specificity Protein 1 (SP1) or signal transducer and activator of transcription 3 (STAT3) to modulate the transcription of growth arrest-specific 6 (GAS6) and early growth ...
Hui Guo, Wei Liu, Pingping Tan
doaj   +1 more source