Results 41 to 50 of about 1,060,446 (249)
Identification of metabolites, clinical chemistry markers and transcripts associated with hepatotoxicity. [PDF]
PLoS ONE, 2014 Early and accurate pre-clinical and clinical biomarkers of hepatotoxicity facilitate the drug development process and the safety monitoring in clinical studies.
Andreas Buness +6 more
doaj +1 more source
Review: Nutritional regulation of muscle growth in neonatal swine
Animal, 2023 Despite advances in the nutritional support of low birth weight and early-weaned piglets, most experience reduced extrauterine growth performance. To further optimize nutritional support and develop targeted intervention strategies, the mechanisms that ...
E.A. Posey, T.A. Davis
doaj +1 more source
Viruses, 2018 Evolution has equipped poxvirus genomes with the coding capacity for several virus-host interaction products which interfere with host cell gene expression and protein function, creating an adequate intracellular environment for a productive infection ...
Leonardo C. de Oliveira +7 more
doaj +1 more source
Upregulation of early growth response factor-1 by bile acids requires mitogen-activated protein kinase signaling [PDF]
Toxicology and Applied Pharmacology, 2010 Cholestasis results when excretion of bile acids from the liver is interrupted. Liver injury occurs during cholestasis, and recent studies showed that inflammation is required for injury. Our previous studies demonstrated that early growth response factor-1 (Egr-1) is required for development of inflammation in liver during cholestasis, and that bile ...
Katryn, Allen +3 more
openaire +2 more sources
Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence [PDF]
Proceedings of the National Academy of Sciences, 2003 The proliferation of most primary cells in culture is limited by replicative senescence and crisis, p53-dependent events. However, the regulation of p53 itself has not been defined. We find that deletion of the early growth response 1 (EGR1) transcription factor leads to a striking phenotype, including complete bypass of senescence and ...
Anja, Krones-Herzig +2 more
openaire +2 more sources
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa +3 more
wiley +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Regulation of apoA-I gene expression
Journal of Lipid Research, 2004 We have previously shown that 17-β-estradiol (E2) and genistein increase the expression of apolipoprotein A-I (apoA-I), the major protein component of HDL, in Hep G2 cells.
Stefania Lamon-Fava, Dale Micherone
doaj +1 more source
Frontiers in Plant Science, 2021 Abscisic acid (ABA) is an important phytohormone regulating plant growth, development and stress responses. A multitude of key factors implicated in ABA signaling have been identified; however, the regulation network of these factors needs for further ...
Xiao-Pu Shi +8 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source