Results 71 to 80 of about 1,060,446 (249)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Balitora dehouensis, a new species of cave-dwelling hillstream loach (Teleostei, Cypriniformes, Balitoridae) from the upper Red River, southwestern China [PDF]

Zoosystematics and Evolution
A new species of cave-dwelling hillstream loach (Balitoridae, Cypriniformes), Balitora dehouensis sp. nov. is described from a cave in Wenshan Zhuang and Miao Autonomous Prefecture, Yunnan Province, China. Balitora dehouensis sp. nov.
Hao-Tian Lei, Xin-Rui Pu, Hong-Fu Yang, Ming-Xin Zhu, Hao-Lin Mo, Xiao-Yu Liu, Mo Wang, Bao-Liang Bi   +7 more
doaj   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Proinflammatory Cytokines Increase Vascular Endothelial Growth Factor Expression in Alveolar Epithelial Cells

Mediators of Inflammation, 2015
Vascular endothelial growth factor (VEGF) is an endothelial permeability mediator that is highly expressed in lung epithelium. In nonlung cells proinflammatory cytokines have been shown to increase VEGF expression, but their effects on lung epithelium ...
James P. Maloney, Li Gao
doaj   +1 more source

Early growth response‐1 induction by fibroblast growth factor‐1 via increase of mitogen‐activated protein kinase and inhibition of protein kinase B in hippocampal neurons [PDF]

British Journal of Pharmacology, 2010
Background and purpose:  The transcription factor early growth response‐1 (Egr‐1) and the acidic fibroblast growth factor (FGF‐1) are involved in many regulatory processes, including hippocampus‐associated learning and memory. However, the intracellular signalling mechanisms regulating Egr‐1 in hippocampal cells are not entirely understood.Experimental
Alexander H, Benz, Mehdi, Shajari, Natalie, Peruzki, Faramarz, Dehghani, Erik, Maronde   +4 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Essential regulatory elements for NHE3 gene transcription in renal proximal tubule cells

Brazilian Journal of Medical and Biological Research, 2011
The objectives of the present study were to identify the cis-elements of the promoter absolutely required for the efficient rat NHE3 gene transcription and to locate positive and negative regulatory elements in the 5’-flanking sequence (5’FS),
E.A. Neri, C.N.A. Bezerra, N.A. Rebouças   +2 more
doaj   +2 more sources