Results 81 to 90 of about 2,848,670 (398)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
, 2011 This review of Chris Wickham's Framing the Early Middle Ages situates the book within the context of his earlier writings on the transition to feudalism, and contrasts his explanation for and dating of the process with those of the two main opposing ...
Davidson, Neil
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Early medieval war-flails (kistens) from Polish lands
Fasciculi Archaeologiae Historicae, 2008 ...
Piotr N. Kotowicz
doaj
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Magnitude of rift-related burial and orogenic contraction in the Marrakech High Atlas revealed by zircon (U-Th)/He thermochronology and thermal modelling [PDF]
, 2016 The Atlas of Morocco is a continental rift developed during the Triassic-Jurassic and moderately inverted during the Cenozoic. The High Atlas south of Marrakech, with exposures of basement and Triassic early synrift deposits, has been viewed as a high ...
Domènech, Mireia +2 more
core +2 more sources
Приноси към българската археология, 2018 The article presents the results of the archaeological excavations at an extra muros church, situated on the northern slope of the Sarnena Gora Mountain, not far from the village of Buzovgrad, Kazanlak region (Figs. 1–3). Built in the early 6th century,
Deyan Rabovyanov +2 more
doaj
La mission archéologique de Jebel Oust, site antique de Tunisie
Archéopages, 2010 The Tunisian site of Jebel Oust (beginnings of the Empire to early 7th c.) is a place of worship (temple) associated with a hot spring (thermae and tanks).
Raphaël Durost +2 more
doaj +1 more source
“Poor” archeological levels not to be forgotten: units of Middle and early Upper Magdalenian age in El Mirón Cave (Ramales de la Victoria, Cantabria, Spain) [PDF]
, 2021 Lawrence Guy Straus +1 more
openalex +1 more source