Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Unitarity problems for an effective field theory description of early universe cosmology. [PDF]
Eur Phys J C Part Fields, 2022 Brandenberger R, Kamali V.
europepmc +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Nearby primitive galaxies offer a window into the early universe. [PDF]
Proc Natl Acad Sci U S A, 2022 Croswell K.
europepmc +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
The Astrophysical JournalWe numerically construct a series of axisymmetric rotating magnetic wind solutions, aiming at exploring the observation properties of massive white dwarf (WD) merger remnants with a strong magnetic field, a fast spin, and an intense mass loss, as ...
Yici Zhong +4 more
doaj +1 more source
Early Universe Thermodynamics and Evolution in Nonviscous and Viscous Strong and Electroweak Epochs: Possible Analytical Solutions. [PDF]
Entropy (Basel), 2021 Tawfik AN, Greiner C.
europepmc +1 more source
Small angular scale CMB anisotropies from CBI and BIMA experiments: Early universe or local structures? [PDF]
, 2002 Asantha Cooray, A. Melchiorri
openalex +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Dynamics of HeHHe+ Rotational State Changes Induced by Collision with He: A Possible New Path in Early Universe Chemistry. [PDF]
J Phys Chem A, 2021 González-Sánchez L +3 more
europepmc +1 more source