Results 41 to 50 of about 985,100 (309)

Early warning signal for interior crises in excitable systems

open access: yes, 2017
The ability to reliably predict critical transitions in dynamical systems is a long-standing goal of diverse scientific communities. Previous work focused on early warning signals related to local bifurcations (critical slowing down) and non-bifurcation ...
Bialonski, Stephan   +2 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

An Interrupted Sampling Repeater Jamming Suppression Algorithm Combines Grey Entropy With Multidimensional Filtering

open access: yesIET Radar, Sonar & Navigation
Interrupted sampling repeater jamming (ISRJ), as a typical intra‐pulse coherent interference, seriously endangers the performance of radar. To effectively suppress ISRJ, the paper proposes an ISRJ suppression algorithm combines grey entropy with ...
Jun Luo   +5 more
doaj   +1 more source

Gender equity in disaster early warning systems [PDF]

open access: yes, 2015
Capacities of societies, communities and individuals or a social-ecological system to deal with adverse consequences and the impacts of hazard events define the resilience.
Amaratunga, Dilanthi   +2 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Translational Motion Compensation for ISAR Imaging Based on Range Joint Fast Orthogonal Matching Pursuit Algorithm

open access: yesIEEE Access, 2022
Accurate translational motion compensation (TMC) is the key procedure of inverse synthetic aperture radar (ISAR) imaging. Under the condition of sparse aperture, the correlation of adjacent pulses is severely destroyed, which brings a few challenges to ...
Xu Wei   +4 more
doaj   +1 more source

The 2008 rice crisis: shock and new challenges [PDF]

open access: yes, 2011
West Africa currently imports 5.2 million tonnes of rice, compared with 1.7 million tonnes in the early 1990s, and is only able to cover 60% of its needs despite possessing considerable rice-growing potential.
CILSS - MLI   +4 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Multi-Aircraft Formation Recognition Method of Over-the-Horizon Radar Based on Deep Transfer Learning

open access: yesIEEE Access, 2022
Over-the-horizon radar (OTHR) is an important equipment for the ultralong-range early warning in the military, but the use of constant false-alarm rate (CFAR), which is a traditional detection method, makes it difficult in multi-aircraft formation ...
Futai Liang   +4 more
doaj   +1 more source

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