Results 51 to 60 of about 1,083,673 (298)

Disturbance Process of Sandy Gravel Stratum Caused by Shield Tunneling and Ground Settlement Analysis

Frontiers in Earth Science, 2021
This paper analyzed the earth pressure, pore pressure, and surface settlement of the Luoyang urban rail transit tunnel in a sandy gravel stratum (Henan Province, China) under different burial depths by using field measurement methods.
Nie Qingke, Sun Guang, Gao Siyuan, Liu Hongtao, Zhou Lichao, Hou Jianpeng   +5 more
doaj   +1 more source

Spin crossover in ferropericlase from first-principles molecular dynamics

, 2015
Ferropericlase, (Mg,Fe)O, is the second-most abundant mineral of the Earth's lower mantle. With increasing pressure, the Fe ions in the material begin to collapse from a magnetic to non-magnetic spin state.
Holmstrom, Eero, Stixrude, Lars
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Pressure-driven grain fusion and mechanical properties improvement of high-entropy (Ti0.2Zr0.2Nb0.2Hf0.2Ta0.2)C ceramics

Materials & Design
Dense and fine-grained high entropy transition metal carbides are considered as one of the most promising materials with superior hardness, fracture toughness and electrical conductivity.
Wang Chen, Pengfei Shen, Wei Li, Shuailing Ma, Min Lian, Xinmiao Wei, Yaqian Dan, Xingbin Zhao, Mengyao Qi, Tian Cui, Ralf Riedel   +10 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Conductivity-elevated by brucite amorphization and implication for electrical anomalies in shallow subduction zones

Communications Earth & Environment
Pervasive high-conductivity anomalies in shallow cold subduction zones (40–70 km depths, corresponding to 1–2 GPa) remain unexplained by conventional mechanisms (e.g., dehydration fluids).
Weibin Gui, Jin Liu, Jun Hu, Fahui Xiong, Kewei Shen, Yongjun Tian   +5 more
doaj   +1 more source

Seismic Signals of the Wushi M_S7.1 Earthquake of 23 January 2024, Viewed Through the Angle of Hydrogeochemical Characteristics

Applied Sciences
On 23 January 2024, a MS7.1 earthquake struck Wushi County, Xinjiang Uygur Autonomous Region, marking the largest seismic event in the Southern Tianshan (STS) region in the past century. This study investigates the relationship between hydrothermal fluid
Zhaojun Zeng, Xiaocheng Zhou, Jinyuan Dong, Jingchao Li, Miao He, Jiao Tian, Yuwen Wang, Yucong Yan, Bingyu Yao, Shihan Cui, Gaoyuan Xing, Han Yan, Ruibing Li, Wan Zheng, Yueju Cui   +14 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Numerical Simulation Analysis on Support Performance of Inclined-Vertical Combined Double-Row Interlocked Steel Pipe Piles

Zhongwai Gonglu
To select appropriate support structures in foundation pit engineering of underground tunnels for the Hong Kong International Airport (HKIA), this paper proposed the use of inclined-vertical combined interlocked steel pipe piles, which are beneficial for
ZHOU Yi, ZHANG Ning, WANG Yanhua, ZHOU Dequan   +3 more
doaj   +1 more source