Results 51 to 60 of about 3,446,655 (295)
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Earth First! ! Membership Application
A blank membership application to join Earth First!
Earth First! (Organization)
core +1 more source
Redox reactions in subducted CaCO3–Fe–SiO2 as a potential source of superdeep diamond inclusions
CaCO3 is one of the most abundant carbonates at the Earth’s surface. It is transported into the mantle in substantial quantities via subducted slabs and participates in the deep mantle carbon cycle along with other mantle materials.
Mengqi Guo +5 more
doaj +1 more source
Relationship between earth pressure and wall displacement based on Coulomb earth pressure model
The magnitude of earth pressure is greatly influenced by wall displacement. Based on the viewpoint that the relationship between wall displacement and lateral earth pressure is the macroscopic embodiment of soil stress-strain behavior, the relationship ...
XIE Tao 1,2, LUO Qiang 1,2, ZHANG Liang 1,2, JIANG Liang-wei 1,2, LIAN Ji-feng 1,2
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Dense and fine-grained high entropy transition metal carbides are considered as one of the most promising materials with superior hardness, fracture toughness and electrical conductivity.
Wang Chen +10 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Pervasive high-conductivity anomalies in shallow cold subduction zones (40–70 km depths, corresponding to 1–2 GPa) remain unexplained by conventional mechanisms (e.g., dehydration fluids).
Weibin Gui +5 more
doaj +1 more source
On 23 January 2024, a MS7.1 earthquake struck Wushi County, Xinjiang Uygur Autonomous Region, marking the largest seismic event in the Southern Tianshan (STS) region in the past century. This study investigates the relationship between hydrothermal fluid
Zhaojun Zeng +14 more
doaj +1 more source

