Results 51 to 60 of about 3,634,993 (297)

A calculation method of earth pressure on sheeting between two piles considering soil arching effect and intermediate principal stress

Shuiwen dizhi gongcheng dizhi, 2022
The classical theories of earth pressure are based on the M-C strength criterion, which do not consider the influence of soil arching effect and intermediate principal stress on earth pressure, so the theoretical earth pressures are significantly larger ...
Jinglin YOU, Shijie WANG, Haolan WANG
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Redox reactions in subducted CaCO3–Fe–SiO2 as a potential source of superdeep diamond inclusions

Scientific Reports
CaCO3 is one of the most abundant carbonates at the Earth’s surface. It is transported into the mantle in substantial quantities via subducted slabs and participates in the deep mantle carbon cycle along with other mantle materials.
Mengqi Guo, Xinyang Li, Zhu Mao, Fangfei Li, Liang Li, Qiang Zhou   +5 more
doaj   +1 more source

Relationship between earth pressure and wall displacement based on Coulomb earth pressure model

Yantu gongcheng xuebao, 2018
The magnitude of earth pressure is greatly influenced by wall displacement. Based on the viewpoint that the relationship between wall displacement and lateral earth pressure is the macroscopic embodiment of soil stress-strain behavior, the relationship ...
XIE Tao 1,2, LUO Qiang 1,2, ZHANG Liang 1,2, JIANG Liang-wei 1,2, LIAN Ji-feng 1,2
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Pressure-driven grain fusion and mechanical properties improvement of high-entropy (Ti0.2Zr0.2Nb0.2Hf0.2Ta0.2)C ceramics

Materials & Design
Dense and fine-grained high entropy transition metal carbides are considered as one of the most promising materials with superior hardness, fracture toughness and electrical conductivity.
Wang Chen, Pengfei Shen, Wei Li, Shuailing Ma, Min Lian, Xinmiao Wei, Yaqian Dan, Xingbin Zhao, Mengyao Qi, Tian Cui, Ralf Riedel   +10 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Conductivity-elevated by brucite amorphization and implication for electrical anomalies in shallow subduction zones

Communications Earth & Environment
Pervasive high-conductivity anomalies in shallow cold subduction zones (40–70 km depths, corresponding to 1–2 GPa) remain unexplained by conventional mechanisms (e.g., dehydration fluids).
Weibin Gui, Jin Liu, Jun Hu, Fahui Xiong, Kewei Shen, Yongjun Tian   +5 more
doaj   +1 more source

Seismic Signals of the Wushi M_S7.1 Earthquake of 23 January 2024, Viewed Through the Angle of Hydrogeochemical Characteristics

Applied Sciences
On 23 January 2024, a MS7.1 earthquake struck Wushi County, Xinjiang Uygur Autonomous Region, marking the largest seismic event in the Southern Tianshan (STS) region in the past century. This study investigates the relationship between hydrothermal fluid
Zhaojun Zeng, Xiaocheng Zhou, Jinyuan Dong, Jingchao Li, Miao He, Jiao Tian, Yuwen Wang, Yucong Yan, Bingyu Yao, Shihan Cui, Gaoyuan Xing, Han Yan, Ruibing Li, Wan Zheng, Yueju Cui   +14 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source