Results 61 to 70 of about 1,079,884 (299)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Pressure-driven grain fusion and mechanical properties improvement of high-entropy (Ti0.2Zr0.2Nb0.2Hf0.2Ta0.2)C ceramics

Materials & Design
Dense and fine-grained high entropy transition metal carbides are considered as one of the most promising materials with superior hardness, fracture toughness and electrical conductivity.
Wang Chen, Pengfei Shen, Wei Li, Shuailing Ma, Min Lian, Xinmiao Wei, Yaqian Dan, Xingbin Zhao, Mengyao Qi, Tian Cui, Ralf Riedel   +10 more
doaj   +1 more source

Single crystal growth of the pyrochlores $R_2$Ti$_2$O$_7$ ($R$ = rare earth) by the optical floating-zone method

, 2013
We report a systematic study on the crystal growth of the rare-earth titanates $R_2$Ti$_2$O$_7$ ($R$ = Gd, Tb, Dy, Ho, Y, Er, Yb and Lu) and Y-doped Tb$_{2-x}$Y$_x$Ti$_2$O$_7$ ($x$ = 0.2 and 1) using an optical floating-zone method.
Fan, C., Li, Q. J., Lv, Y. Y., Ni, B., Sun, X. F., Xu, L. M., Zhang, F. B., Zhao, Z. Y.   +7 more
core   +1 more source

Melting and metallization of silica in the cores of gas giants, ice giants and super Earths [PDF]

, 2014
The physical state and properties of silicates at conditions encountered in the cores of gas giants, ice giants and of Earth like exoplanets now discovered with masses up to several times the mass of the Earth remains mostly unknown.
Benuzzi-Mounaix, A., Guyot, F., Mazevet, S., Taniuchi, T., Tsuchiya, T.   +4 more
core   +2 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Seismic Signals of the Wushi M_S7.1 Earthquake of 23 January 2024, Viewed Through the Angle of Hydrogeochemical Characteristics

Applied Sciences
On 23 January 2024, a MS7.1 earthquake struck Wushi County, Xinjiang Uygur Autonomous Region, marking the largest seismic event in the Southern Tianshan (STS) region in the past century. This study investigates the relationship between hydrothermal fluid
Zhaojun Zeng, Xiaocheng Zhou, Jinyuan Dong, Jingchao Li, Miao He, Jiao Tian, Yuwen Wang, Yucong Yan, Bingyu Yao, Shihan Cui, Gaoyuan Xing, Han Yan, Ruibing Li, Wan Zheng, Yueju Cui   +14 more
doaj   +1 more source

Reply to the discussion by Ganesh on “Analysis of passive earth pressure modification due to seepage flow effects" [PDF]

, 2018
Using an assumed vertical retaining wall with a drainage system along the soil–structure interface, this paper analyses the effect of anisotropic seepage flow on the development of passive earth pressure.
Hu, Z, Wilkinson, Stephen, Yang, Z.X.
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Seismic Earth Pressure Development in Sheet Pile Retaining Walls: A Numerical Study

, 2014
The design of retaining walls requires the complete knowledge of the earth pressure distribution behind the wall. Due to the complex soil-structure effect, the estimation of earth pressure is not an easy task; even in the static case. The problem becomes
Bui, Ha H., Rajeev, P., Sivakugan, N.
core   +1 more source