Results 41 to 50 of about 11,929 (196)

Deployable CRISPR-Cas13a diagnostic tools to detect and report Ebola and Lassa virus cases in real-time

Nature Communications, 2020
Outbreaks of viral hemorrhagic fevers highlight the need for sensitive, field-deployable diagnostics. Here the authors present a CRISPR-based SHERLOCK platform with field protocol and mobile app for Ebola and Lassa fever outbreaks.
Kayla G. Barnes, Anna E. Lachenauer, Adam Nitido, Sameed Siddiqui, Robin Gross, Brett Beitzel, Katherine J. Siddle, Catherine A. Freije, Bonnie Dighero-Kemp, Samar B. Mehta, Amber Carter, Jessica Uwanibe, Fehintola Ajogbasile, Testimony Olumade, Ikponmwosa Odia, John Demby Sandi, Mambu Momoh, Hayden C. Metsky, Chloe K. Boehm, Aaron E. Lin, Molly Kemball, Daniel J. Park, Luis Branco, Matt Boisen, Brian Sullivan, Mihret F. Amare, Abdulwasiu B. Tiamiyu, Zahra F. Parker, Michael Iroezindu, Donald S. Grant, Kayvon Modjarrad, Cameron Myhrvold, Robert F. Garry, Gustavo Palacios, Lisa E. Hensley, Stephen F. Schaffner, Christian T. Happi, Andres Colubri, Pardis C. Sabeti   +38 more
doaj   +1 more source

Imported viral haemorrhagic fever with a potential for person-to-person transmission: review and recommendations for initial management of a suspected case in Belgium.

, 2002
Viral haemorrhagic fevers are caused by a wide range of viruses. There are 4 types of viruses well known to spread from person to person and able to cause nosocomial outbreaks with a high case fatality rate: an arenavirus (Lassa fever and more ...
Borchert, M., Moreau, M, Borchert, M, Colebunders, Robert, Colebunders, R, Moreau, M., Van Esbroeck, M., Van Esbroeck, M, Colebunders, R.   +8 more
core   +1 more source

Ebola Hemorrhagic Fever and Septic Shock [PDF]

The Journal of Infectious Diseases, 2003
Ebola virus is the cause of sporadic outbreaks of lethal Ebola hemorrhagic fever (EHF) in central Africa. Despite the difficulties of studying this virus much has been learned over the past decade about the pathogenesis of Ebola virus infection in humans and nonhuman primates.
Mike Bray, Siddhartha Mahanty
openaire   +1 more source

Use of protective gear and the occurrence of occupational Marburg hemorrhagic fever in health workers from Watsa health zone, Democratic Republic of the Congo.

, 2007
BACKGROUND: Occupational transmission to health workers (HWs) has been a typical feature of Marburg hemorrhagic fever (MHF) outbreaks. The goal of this study was to identify cases of occupational MHF in HWs from Durba and Watsa, Democratic Republic of ...
Libande, Modeste L, MULANGU, S, TSHOMBA, A, Pierre Lefèvre, Muyembe-Tamfum, J. J., Van der Stuyft, Patrick, LIBANDE, ML, Muyembe-Tamfum, Jean-Jacques, Kulidri, Amayo, Tshomba, Antoine, MUYEMBE-TAMFUM, JJ, BORCHERT, M, Antoine Tshomba, Borchert, M., Tshomba, A., Van der Stuyft, P., Libande, M. L., Jean‐Jacques Muyembe‐Tamfum, Modeste L. Libande, Kulidri, A., Amayo Kulidri, Matthias Borchert, Mulangu, Sabue, Mulangu, S., LEFEVRE, P, Sabue Mulangu, KULIDRI, A, Patrick Van der Stuyft, Borchert, Matthias, Lefevre, Pierre, Lefèvre, P.   +30 more
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Undiagnosed Acute Viral Febrile Illnesses, Sierra Leone

Emerging Infectious Diseases, 2014
Sierra Leone in West Africa is in a Lassa fever–hyperendemic region that also includes Guinea and Liberia. Each year, suspected Lassa fever cases result in submission of ≈500–700 samples to the Kenema Government Hospital Lassa Diagnostic Laboratory in ...
Randal J. Schoepp, Cynthia A. Rossi, Sheik H. Khan, Augustine Goba, Joseph N. Fair   +4 more
doaj   +1 more source

Evaluation of the Effectiveness of Nonspecific Medical Protection Against Diseased, Caused of Ebola Virus

Антибиотики и Химиотерапия, 2020
The article presents an analysis of research evaluating the effectiveness of nonspecific means of emergency prevention and treatment of Ebola virus disease.
T. E. Sizikova, v. N. Lebedev, A. A. Petrov, S. V. Borisevich   +3 more
doaj   +1 more source

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, EarlyView.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

Organisation of Health Care During an Outbreak of Marburg Haemorrhagic Fever in the Democratic Republic of Congo, 1999.

, 2004
Organising health care was one of the tasks of the International Scientific and Technical Committee during the 1998-1999 outbreak in Durba/Watsa, in the north-eastern province (Province Orientale), Democratic Republic of Congo.
Tshioko, F., Mustin, J P, Olinda, Loku Abisa, Muyembe-Tamfum, J. J., Sleurs, H, Pirard, Patricia, Mustin, Jean Pierre, Kinuani, L\ue9on, Libande, M, Kinuani, L, Colebunders, Robert, Kinuani, Léon, Muyembe-Tamfum, Jean-Jacques, Libande, Modeste, Tshomba, Antoine, Pirard, P, Colebunders, R., Mustin, J. P., Borchert, M., Tshomba, A., Sleurs, Hilde, Olinda, L. A., Borchert, M, Olinda, L A, Pirard, P., Sleurs, H., Tshomba, A, Kinuani, L., Libande, M., Colebunders, R, Tshioko, Florimond, Borchert, Matthias, Muyembe-Tamfum, J J, Tshioko, F   +33 more
core   +1 more source

One Health Insights From Pteropus medius: Nipah Virus Spillover, Microbiota, and Antimicrobial Resistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Environmental and anthropogenic drivers of antibiotic resistance dissemination. The cycle reinforces how anthropogenic inputs, such as sewage, animal dung, hospital effluent, and agricultural runoff bring resistant bacteria and antibiotic residues into soil and water.
Punam Chowdhury, Shah Md Tanvir Khan, Sajal Roy, Md. Shohel Al Faruk   +3 more
wiley   +1 more source