Results 81 to 90 of about 17,597 (252)

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, Volume 8, Issue 12, December 2025.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Diagnostic schemes for reducing epidemic size of african viral hemorrhagic fever outbreaks

Journal of Infection in Developing Countries, 2014
Introduction: Viral hemorrhagic fever (VHF) outbreaks, with high mortality rates, have often been amplified in African health institutions due to person-to-person transmission via infected body fluids.
Iruka N Okeke, Robert S Manning, Thomas Pfeiffer   +2 more
doaj   +1 more source

Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1

Advanced Science, Volume 12, Issue 48, December 29, 2025.
This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu, Guigen Zhang, Yuan Lin, Shiming Yi, Jingyu Yang, Xueying Lin, Deli Song, Zhiheng Liu, Jiayu Zhang, Ying Zeng, Shanyu Huang, Zhen Fan, Jifu Zhang, Ying Liu, Cheng Hu, Wenbo Zhu, Wei Yin, Jun Hu, Guangmei Yan, Jing Cai, Jiankai Liang   +20 more
wiley   +1 more source

Molecular Mechanisms of Ebola Virus Entry into Permissive Cells

Проблемы особо опасных инфекций, 2015
Ebola virus, representative of the Ebolavirus genus, Filoviridae family, causes severe hemorrhagic fever in humans, with lethality rates amounting up to 90 %. The members of Ebolavirus genus infect a broad range of mammalian cells.
T. E. Sizikova, V. N. Lebedev, V. B. Pantyukhov, S. V. Borisevich   +3 more
doaj   +1 more source

The Ebola virus disease outbreak in Tonkolili district, Sierra Leone: a retrospective analysis of the Viral Haemorrhagic Fever surveillance system, July 2014–June 2015 [PDF]

, 2019
In Sierra Leone, the Ebola virus disease (EVD) outbreak occurred with substantial differences between districts with someone even not affected. To monitor the epidemic, a community event-based surveillance system was set up, collecting data into the ...
Colizzi, Vittorio, DJEUNANG DONGHO, GHYSLAINE BRUNA, Miglietta, Alessandro, Montesano, Carla, Rezza, Giovanni, Russo, Gianluca, Solimini, ANGELO GIUSEPPE, Vullo, Vincenzo   +7 more
core   +1 more source

Ebola viral hemorrhagic fever

Journal of Health Policy & Outcomes Research, 2014
Pathogens causing transmissible viral hemorrhagic fevers are therefore classified internationally at the most dangerous hazard level. Most of them may be transmitted through the respiratory tract into human being. For this reason aerosol dissemination of viral pathogens may be considered as biological weapon.
openaire   +1 more source

Drug Repurposing Investigation for Combating Ebola Virus Disease: Database Mining, Docking Calculations, Molecular Dynamics, and Density Functional Theory Study

ChemistryOpen, Volume 14, Issue 12, December 2025.
DrugBank database is mined to hunt prospective Ebola virus (EBOV) VP35 inhibitors utilizing docking calculations, molecular dynamics, molecular mechanics/generalized Born surface area binding energy calculations, and density functional theory computations.
Alaa H. M. Abdelrahman, Gamal A. H. Mekhemer, Peter A. Sidhom, Mohamed A. El‐Tayeb, Shahzeb Khan, Mahmoud A. A. Ibrahim   +5 more
wiley   +1 more source

Quantification of heterogeneity in human CD8+ T cell responses to vaccine antigens: an HLA-guided perspective

Frontiers in Immunology
Vaccines have historically played a pivotal role in controlling epidemics. Effective vaccines for viruses causing significant human disease, e.g., Ebola, Lassa fever, or Crimean Congo hemorrhagic fever virus, would be invaluable to public health ...
Duane C. Harris, Apoorv Shanker, Makaela M. Montoya, Trent R. Llewellyn, Anna R. Matuszak, Aditi Lohar, Jessica Z. Kubicek-Sutherland, Ying Wai Li, Kristen Wilding, Ben Mcmahon, Sandrasegaram Gnanakaran, Ruy M. Ribeiro, Alan S. Perelson, Carmen Molina-París   +13 more
doaj   +1 more source

Ecologic and Geographic Distribution of Filovirus Disease

Emerging Infectious Diseases, 2004
We used ecologic niche modeling of outbreaks and sporadic cases of filovirus-associated hemorrhagic fever (HF) to provide a large-scale perspective on the geographic and ecologic distributions of Ebola and Marburg viruses.
A. Townsend Peterson, John T. Bauer, James N. Mills   +2 more
doaj   +1 more source

A systematic review and meta-analysis of seroprevalence surveys of ebolavirus infection. [PDF]

, 2017
Asymptomatic ebolavirus infection could greatly influence transmission dynamics, but there is little consensus on how frequently it occurs or even if it exists. This paper summarises the available evidence on seroprevalence of Ebola, Sudan and Bundibugyo
Bower, Hilary, Glynn, Judith R
core   +2 more sources