Results 1 to 10 of about 41,247 (202)
Virus-Vectored Ebola Vaccines. [PDF]
Acta Naturae, 2017 The Ebola virus disease (EVD) is one of the most dangerous infections affecting humans and animals. The first EVD outbreaks occurred in 1976 in Sudan and Zaire. Since then, more than 20 outbreaks have occurred; the largest of which (2014-2016) evolved into an epidemic in West Africa and claimed the lives of more than 11,000 people. Although vaccination
Dolzhikova IV +13 more
europepmc +4 more sources
Expert Opin Biol Ther, 2012 Ebolaviruses cause severe viral hemorrhagic fever in humans and non-human primates (NHPs), with case fatality rates of up to 90%. Currently, neither a specific treatment nor a vaccine licensed for use in humans is available. However, a number of vaccine candidates have been developed in the last decade that are highly protective in NHPs, the gold ...
Hoenen T, Groseth A, Feldmann H.
europepmc +4 more sources
Ebola vaccines - Where are we? [PDF]
Hum Vaccin Immunother, 2016 The 2014-16 Ebola outbreak in West Africa has by far been the largest and most devastating Ebola outbreak so far. At the start of the epidemic only 2 Ebola DNA vaccine candidates had been tested in clinical trials and the correlate of protection in humans was unknown.
Watle SV, Norheim G, Røttingen JA.
europepmc +4 more sources
Clinical development of Ebola vaccines. [PDF]
Ther Adv Vaccines, 2015 The ongoing outbreak of Ebola virus disease in West Africa highlighted the lack of a licensed drug or vaccine to combat the disease and has renewed the urgency to develop a pipeline of Ebola vaccines. A number of different vaccine platforms are being developed by assessing preclinical efficacy in animal models and expediting clinical development. Over
Sridhar S.
europepmc +4 more sources
Harnessing case isolation and ring vaccination to control Ebola. [PDF]
PLoS Neglected Tropical Diseases, 2015 As a devastating Ebola outbreak in West Africa continues, non-pharmaceutical control measures including contact tracing, quarantine, and case isolation are being implemented.
Chad Wells +11 more
doaj +6 more sources
The Lancet, 2015 We welcome the results from the Ebola ça Suffit (“Ebola that is enough”) trial, emphasising the potential importance of a vaccine in controlling Ebola virus disease. However, parallel development in children and adolescents is scarce. More than 3000 confirmed cases of Ebola virus disease in children younger than 14 years have been reported, including ...
Fitzgerald, F +4 more
openaire +4 more sources
Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges
Vaccines, 2023 The global outgoing outbreaks of Ebola virus disease (EVD) in different regions of Sudan, Uganda, and Western Africa have brought into focus the inadequacies and restrictions of pre-designed vaccines for use in the battle against EVD, which has affirmed ...
Sumira Malik +11 more
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Scientific African, 2021 Ebola virus is a neglected tropical disease widely accepted as one of the most fatal diseases of human and nonhuman primates ever encountered in recent years. For a long time, development of vaccines and anti-Ebola drugs has been slow.
Collins Kipkorir Kebenei, Patrick Okoth
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Viruses, 2022 The Ebola virus has caused outbreaks in Central and West Africa, with high rates of morbidity and mortality. Clinical trials of recombinant virally vectored vaccines did not explicitly include pregnant or nursing women, resulting in a gap in knowledge of
Caitlin A. Williams +4 more
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