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Ebola virus disease [PDF]

Nature Reviews Disease Primers, 2020
Ebola virus disease (EVD) is a severe and frequently lethal disease caused by Ebola virus (EBOV). EVD outbreaks typically start from a single case of probable zoonotic transmission, followed by human-to-human transmission via direct contact or contact ...
Shevin T. Jacob, Ian Crozier, W. Fischer, Angela L Hewlett, C. Kraft, Marc-Antoine de La Vega, Moses J. Soka, Victoria Wahl, A. Griffiths, Laura Bollinger, J. Kuhn   +10 more
semanticscholar   +7 more sources

Persistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study [PDF]

The Lancet Global Health, 2017
Summary: Background: By January, 2016, all known transmission chains of the Ebola virus disease (EVD) outbreak in west Africa had been stopped. However, there is concern about persistence of Ebola virus in the reproductive tract of men who have survived
Daouda Sissoko, MD, Sophie Duraffour, PhD, Romy Kerber, PhD, Jacques Seraphin Kolie, MD, Abdoul Habib Beavogui, PhD, Alseny-Modet Camara, MD, Géraldine Colin, PharmD, Toni Rieger, PhD, Lisa Oestereich, PhD, Bernadett Pályi, MSc, Stephanie Wurr, Jeremie Guedj, PhD, Thi Huyen Tram Nguyen, PhD, Rosalind M Eggo, PhD, Conall H Watson, MFPH, W John Edmunds, PhD, Joseph Akoi Bore, MSc, Fara Raymond Koundouno, MSc, Mar Cabeza-Cabrerizo, MSc, Lisa L Carter, PhD, Liana Eleni Kafetzopoulou, MSc, Eeva Kuisma, PhD, Janine Michel, PhD, Livia Victoria Patrono, PhD, Natasha Y Rickett, MRes, Katrin Singethan, PhD, Martin Rudolf, PhD, Angelika Lander, Elisa Pallasch, Sabrina Bockholt, Estefanía Rodríguez, PhD, Antonino Di Caro, MD, Roman Wölfel, MD, Martin Gabriel, MD, Céline Gurry, Pierre Formenty, DVM, Sakoba Keïta, MD, Denis Malvy, PhD, Miles W Carroll, PhD, Xavier Anglaret, PhD, Stephan Günther, DrMD   +40 more
doaj   +3 more sources

Seroprevalence of Ebola virus infection in Bombali District, Sierra Leone [PDF]

Journal of Public Health in Africa, 2017
A serosurvey of anti-Ebola Zaire virus nucleoprotein IgG prevalence was carried out among Ebola virus disease survivors and their Community Contacts in Bombali District, Sierra Leone. Our data suggest that the specie of Ebola virus (Zaire) responsible of
Nadege Goumkwa Mafopa, Gianluca Russo, Raoul Emeric Guetiya Wadoum, Emmanuel Iwerima, Vincent Batwala, Marta Giovanetti, Antonella Minutolo, Patrick Turay, Thomas B. Turay, Brima Kargbo, Massimo Amicosante, Mattei Maurizio, Carla Montesano, Ebola Study Group   +13 more
doaj   +4 more sources

Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges

Vaccines, 2023
The global outgoing outbreaks of Ebola virus disease (EVD) in different regions of Sudan, Uganda, and Western Africa have brought into focus the inadequacies and restrictions of pre-designed vaccines for use in the battle against EVD, which has affirmed ...
S. Malik, Shristi Kishore, Sagnik Nag, Archna Dhasmana, S. Preetam, Oishi Mitra, Darwin A. León-Figueroa, A. Mohanty, Vijay Kumar Chattu, Marjan Assefi, B. Padhi, R. Sah   +11 more
semanticscholar   +1 more source

Structure of the Ebola virus polymerase complex

Nature, 2022
Filoviruses, including Ebola virus, pose an increasing threat to the public health. Although two therapeutic monoclonal antibodies have been approved to treat the Ebola virus disease 1 , 2 , there are no approved broadly reactive drugs to control diverse
Bin Yuan, Qi Peng, Jinlong Cheng, Min Wang, Jin Zhong, Jianxun Qi, G. Gao, Yi Shi   +7 more
semanticscholar   +1 more source

Current state of Ebola virus vaccines: A snapshot

PLoS Pathogens, 2021
Why are Ebola virus vaccines needed? Four species of the genus Ebolavirus cause severe and often lethal disease in humans: Sudan ebolavirus (SUDV), Bundibugyo ebolavirus (BDBV), Taï Forest ebolavirus (TAFV), and Zaire ebolavirus (EBOV) [1]. Historically,
Courtney Woolsey, T. Geisbert
semanticscholar   +1 more source

Partnership for Research on Ebola VACcination (PREVAC): protocol of a randomized, double-blind, placebo-controlled phase 2 clinical trial evaluating three vaccine strategies against Ebola in healthy volunteers in four West African countries

Trials, 2021
Introduction The Ebola virus disease (EVD) outbreak in 2014–2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preventative vaccine.
Moses Badio, Edouard Lhomme, Mark Kieh, Abdoul Habib Beavogui, Stephen B. Kennedy, Seydou Doumbia, Bailah Leigh, Samba O. Sow, Alpha Diallo, Daniela Fusco, Matthew Kirchoff, Monique Termote, Renaud Vatrinet, Deborah Wentworth, Helène Esperou, H. Clifford Lane, Jerome Pierson, Deborah Watson-Jones, Céline Roy, Eric D’Ortenzio, Brian Greenwood, Genevieve Chêne, Laura Richert, James D. Neaton, Yazdan Yazdanpanah, the PREVAC study team   +25 more
doaj   +1 more source

What did we learn from preparing for cross-border transmission of Ebola virus disease into a complex humanitarian setting – The Republic of South Sudan?

Infectious Diseases of Poverty, 2020
Background Following the West Africa Ebola virus disease (EVD) outbreak (2013–2016), WHO developed a preparedness checklist for its member states. This checklist is currently being applied for the first time on a large and systematic scale to prepare for
Olushayo Oluseun Olu, Richard Lako, Joseph Francis Wamala, Patrick Otim Ramadan, Caroline Ryan, Ifeanyi Udenweze, Kibebu Berta, Argata Guracha Guyo, Alex Sokemawu, Michael Tukuru, Henry John Gray, Alex Chimbaru   +11 more
doaj   +1 more source

Development of an EBOV MiniG plus system as an advanced tool for anti-Ebola virus drug screening

Heliyon, 2023
The incidence of zoonotic diseases, such as coronavirus disease 2019 and Ebola virus disease, is increasing worldwide. However, drug and vaccine development for zoonotic diseases has been hampered because the experiments involving live viruses are ...
Chi-Ju Hsu, Cheng-Hsiu Chen, Wen-Ting Chen, Ping-Cheng Liu, Tein-Yao Chang, Meng-He Lin, Cheng-Cheung Chen, Hsing-Yu Chen, Chih-Heng Huang, Yun-Hsiang Cheng, Jun-Ren Sun   +10 more
doaj   +1 more source

Predicting the extinction of Ebola spreading in Liberia due to mitigation strategies [PDF]

, 2015
The Ebola virus is spreading throughout West Africa and is causing thousands of deaths. In order to quantify the effectiveness of different strategies for controlling the spread, we develop a mathematical model in which the propagation of the Ebola virus
Braunstein, L. A., Rêgo, H. H. A., Stanley, H. E., Valdez, L. D.   +3 more
core   +5 more sources