Results 131 to 140 of about 1,763,176 (361)

Populations Addressed in Vaccines Approved via the European Medicines Agency

Clinical Pharmacology &Therapeutics, EarlyView.
Therapeutic and prophylactic agents require robust evidence before patient use. Randomized controlled trials are essential for evaluating safety and efficacy but often exclude specific populations that are also targets for the intervention. This study assessed which populations are included in vaccine registration studies and/or addressed in label ...
Débora D. Gräf, Lukas Westphal, Jonathan Kimmelman, Christine E. Hallgreen   +3 more
wiley   +1 more source

Early control of viral load by favipiravir promotes survival to Ebola virus challenge and prevents cytokine storm in non-human primates.

PLoS Neglected Tropical Diseases, 2021
Ebola virus has been responsible for two major epidemics over the last several years and there has been a strong effort to find potential treatments that can improve the disease outcome.
Stéphanie Reynard, Emilie Gloaguen, Nicolas Baillet, Vincent Madelain, Jérémie Guedj, Hervé Raoul, Xavier de Lamballerie, Jimmy Mullaert, Sylvain Baize   +8 more
doaj   +1 more source

Deaths, late deaths, and role of infecting dose in Ebola virus disease in Sierra Leone: retrospective cohort study. [PDF]

, 2016
OBJECTIVES:  To assess the frequency of fatal recrudescence from Ebola virus disease after discharge from treatment centres, and explore the influence of infecting dose on case fatality rates. DESIGN:  Retrospective cohort study.
Bangura, Mohamed S, Bower, Hilary, Checchi, Francesco, Glynn, Judith R, Johnson, Sembia, Kamara, Osman, Oza, Shefali, Smout, Elizabeth, Turay, Cecilia   +8 more
core   +1 more source

Ebola Virus Disease Outbreak — Democratic Republic of the Congo, August 2018–November 2019

MMWR. Morbidity and mortality weekly report, 2019
On August 1, 2018, the Democratic Republic of the Congo Ministry of Health (DRC MoH) declared the tenth outbreak of Ebola virus disease (Ebola) in DRC, in the North Kivu province in eastern DRC on the border with Uganda, 8 days after another Ebola ...
Aaron Aruna, P. Mbala, Luigi Minikulu, Daniel Mukadi, Dorothée Bulemfu, Franck Edidi, J. Bulabula, Gaston P. Tshapenda, Justus M Nsio, Richard O Kitenge, Gisèle Mbuyi, Celestin Mwanzembe, John Kombe, L. Lubula, Jean-Christophe Shako, Mathias Mossoko, Felix Mulangu, Annie Mutombo, E. Sana, Yannick Tutu, Laetycia Kabange, Jonathan Makengo, Fortunat Tshibinkufua, S. Ahuka-Mundeke, J. Muyembe, Ebola Response Cdc, Walter A Alarcon, Jesse Bonwitt, Dante Bugli, N. Bustamante, Mary J. Choi, Benjamin A. Dahl, K. Decock, A. Dismer, R. Doshi, C. Dubray, D. Fitter, Margherita E. Ghiselli, N. Hall, A. Ben Hamida, A. McCollum, John C. Neatherlin, P. Raghunathan, Fatima Ravat, M. Reynolds, Adriana Rico, N. Smith, G. Soke, Aimée Trudeau, Kerton R Victory, M. Worrell   +50 more
semanticscholar   +1 more source

Analysis of Ebola Virus Entry Into Macrophages [PDF]

Journal of Infectious Diseases, 2015
Published by Oxford Univ. Press, Oxford [u.a.]
Dahlmann, Franziska, Biedenkopf, Nadine, Babler, Anne, Jahnen-Dechent, Willi, Karsten, Christina B., Gnirß, Kerstin, Schneider, Heike, Wrensch, Florian, O'Callaghan, Christopher A., Bertram, Stephanie, Herrler, Georg, Becker, Stephan, Pöhlmann, Stefan, Hofmann-Winkler, Heike   +13 more
openaire   +6 more sources

The Interplay of Public Administration and Community Resilience During the COVID‐19 Pandemic—A Rapid Scoping Review

Conflict Resolution Quarterly, EarlyView.
ABSTRACT This rapid scoping review examines the interplay between public administration and community resilience during the COVID‐19 pandemic, focusing on the type of research conducted, emerging themes in resilience studies, and key lessons learned. The findings show that research in the Global North has primarily examined resilience at the city level,
Daniela Gröschke
wiley   +1 more source

Ebola virus disease: past, present and future

Asian Pacific Journal of Tropical Biomedicine, 2015
Ebola virus disease is one of the most deadly ailments known to mankind due to its high mortality rate (up to 90%) accompanying with the disease. Ebola haemorrhagic fever (EHF) is an infectious disease of animal that can be transmitted to both human and ...
Harish Rajak, Deepak Kumar Jain, Avineesh Singh, Ajay Kumar Sharma, Anshuman Dixit   +4 more
doaj   +1 more source

A review of epidemiological parameters from Ebola outbreaks to inform early public health decision-making. [PDF]

, 2015
The unprecedented scale of the Ebola outbreak in West Africa has, as of 29 April 2015, resulted in more than 10,884 deaths among 26,277 cases. Prior to the ongoing outbreak, Ebola virus disease (EVD) caused relatively small outbreaks (maximum outbreak ...
Bento, AI, Donnelly, CA, Ferguson, NM, Mills, HL, Van Kerkhove, MD   +4 more
core   +1 more source

Silver Nanoparticle‐Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review

Global Challenges, EarlyView.
Silver nanoparticles (AgNPs) exhibit broad‐spectrum antiviral activity by targeting key viral structures and processes. They disrupt viral envelopes, compromising integrity, and bind to nucleocapsids, impairing viral replication. AgNPs also inhibit glycoprotein interactions, preventing viral attachment and entry into host cells.
Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, Flora Salzano, Massimiliano Galdiero, Aliosha Bakuridze, Veronica Folliero   +8 more
wiley   +1 more source

Ebola Haemorrhagic Fever in Africa: a Necessary Highlight [PDF]

, 2019
The purpose of this commentary is to re-evaluate the historic and scientific facts on Ebola haemorrhagic fever and the role of the International community, especially Economic Community of West African States (ECOWAS) in stemming the tide.
Adu-Gyamfi, S. (Samuel)
core   +3 more sources