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Current state of Ebola virus vaccines: A snapshot
PLoS Pathogens, 2021 Why are Ebola virus vaccines needed? Four species of the genus Ebolavirus cause severe and often lethal disease in humans: Sudan ebolavirus (SUDV), Bundibugyo ebolavirus (BDBV), Taï Forest ebolavirus (TAFV), and Zaire ebolavirus (EBOV) [1]. Historically,
Courtney Woolsey, T. Geisbert
semanticscholar +1 more source
Frontiers in Public Health, 2023 Ebola is a highly pathogenic virus, which in humans reaches a mortality rate above 50%. Due to a lack of laboratories in territories where Ebola viruses are endemic and the limited number of surveillance programmes, tests for the confirmation of suspected cases of Ebola are often performed in Reference Laboratories.
Bettini, Aurora +2 more
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Development of an EBOV MiniG plus system as an advanced tool for anti-Ebola virus drug screening
Heliyon, 2023 The incidence of zoonotic diseases, such as coronavirus disease 2019 and Ebola virus disease, is increasing worldwide. However, drug and vaccine development for zoonotic diseases has been hampered because the experiments involving live viruses are ...
Chi-Ju Hsu +10 more
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Trials, 2021 Introduction The Ebola virus disease (EVD) outbreak in 2014–2016 in West Africa was the largest on record and provided an opportunity for large clinical trials and accelerated efforts to develop an effective and safe preventative vaccine.
Moses Badio +25 more
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Infectious Diseases of Poverty, 2020 Background Following the West Africa Ebola virus disease (EVD) outbreak (2013–2016), WHO developed a preparedness checklist for its member states. This checklist is currently being applied for the first time on a large and systematic scale to prepare for
Olushayo Oluseun Olu +11 more
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Adult and paediatric haematology and clinical chemistry laboratory reference limits for Liberia
African Journal of Laboratory Medicine, 2020 Background: As more research is conducted in Liberia, there is a need for laboratory reference limits for common chemistry and haematology values based on a healthy population. Reference limits from the United States may not be applicable.
Mark W. Kieh +10 more
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Microbiology Spectrum, 2022 Ebola virus, a member of the Filoviridae family, utilizes the attachment factors on host cells to support its entry and cause severe tissue damage. TIM-1 has been identified as a predominant attachment factor via interaction with phosphatidylserine (PS ...
Min Zhang +14 more
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Infectious Diseases of Poverty, 2015 Ebola virus disease (EVD) has mostly affected economically deprived countries as limited resources adversely affect a country's infrastructure and administration. Probing into the factors that led to the widespread outbreak, setting forth plans to counter EVD cases in developing countries, and devising definitive measures to limit the spread of the ...
Ghazanfar, Haider +3 more
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MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses
Science, 2020 The CIITAdel keeps viruses at bay A better understanding of cellular mechanisms involved in viral resistance is needed for the next generation of antiviral therapies. Bruchez et al.
Anna M. Bruchez +14 more
semanticscholar +1 more source
Emerging Microbes and Infections, 2023 Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022, Sudan virus re-
Markus H. Kainulainen +11 more
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