Results 21 to 30 of about 1,757,150 (280)

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics.

New England Journal of Medicine, 2019
BACKGROUND Although several experimental therapeutics for Ebola virus disease (EVD) have been developed, the safety and efficacy of the most promising therapies need to be assessed in the context of a randomized, controlled trial.
S. Mulangu, L. Dodd, R. Davey, Olivier Tshiani Mbaya, M. Proschan, Daniel Mukadi, Mariano Lusakibanza Manzo, Didier Nzolo, Antoine Tshomba Oloma, Augustin Ibanda, Rosine Ali, Sinaré Coulibaly, A. Levine, R. Grais, Janet Diaz, H. Lane, J. Muyembé‑Tamfum, Billy Sivahera, Modet Camara, R. Kojan, R. Walker, Bonnie Dighero-kemp, H. Cao, Philippe Mukumbayi, P. Mbala-Kingebeni, Steve Ahuka, S. Albert, Tyler Bonnett, Ian Crozier, Michael Duvenhage, C. Proffitt, M. Teitelbaum, T. Moench, J. Aboulhab, K. Barrett, Kelly Cahill, Katherine Cone, R. Eckes, L. Hensley, B. Herpin, E. Higgs, J. Ledgerwood, J. Pierson, M. Smolskis, Ydrissa Sow, J. Tierney, S. Sivapalasingam, W. Holman, Nikki Gettinger, D. Vallée, J. Nordwall   +50 more
semanticscholar   +1 more source

The laboratory health system and its response to the Ebola virus disease outbreak in Liberia

African Journal of Laboratory Medicine, 2016
The laboratory system in Liberia has generally been fragmented and uncoordinatedAccordingly, the country’s Ministry of Health established the National Reference Laboratoryto strengthen and sustain laboratory services. However, diagnostic testing services
Stephen B. Kennedy, Christine L. Wasunna, John B. Dogba, Philip Sahr, Candace B. Eastman, Fatorma K. Bolay, Gloria T. Mason, Mark W.S. Kieh   +7 more
doaj   +1 more source

A review of strategies used to retain participants in clinical research during an infectious disease outbreak: The PREVAIL I Ebola vaccine trial experience

Contemporary Clinical Trials Communications, 2018
Introduction: This article describes a retrospective review of participant follow-up and retention strategies in the Partnership for Research on the Ebola Virus in Liberia (PREVAIL) I Vaccine Trial.
Sarah Browne, Tarweh Carter, Risa Eckes, Greg Grandits, Melvin Johnson, Irene Moore, Laura McNay   +6 more
doaj   +1 more source

Comparison of Aerosol Stability of Different Variants of Ebola Virus and Marburg Virus and Virulence of Aerosolised Ebola Virus in an Immune-Deficient Mouse

Viruses, 2022
During outbreaks of virus diseases, many variants may appear, some of which may be of concern. Stability in an aerosol of several Ebola virus and Marburg virus variants was investigated.
Sophie J. Smither, Lin S. Eastaugh, Mark S. Lever   +2 more
doaj   +1 more source

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Nature, 2016
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents ...
Travis K Warren, R. Jordan, Michael K. Lo, A. Ray, R. Mackman, V. Soloveva, D. Siegel, M. Perron, R. Bannister, H. Hui, Nate Larson, R. Strickley, Jay B. Wells, Kelly S. Stuthman, Sean A. van Tongeren, N. Garza, G. Donnelly, A. Shurtleff, Cary J. Retterer, D. Gharaibeh, Rouzbeh Zamani, Tara A. Kenny, Brett Eaton, Elizabeth C. Grimes, Lisa S. Welch, L. Gomba, C. Wilhelmsen, D. Nichols, J. Nuss, Elyse R. Nagle, Jeffrey R. Kugelman, G. Palacios, Edward M. Doerffler, Sean Neville, Ernest A. Carra, M. Clarke, Lijun Zhang, W. Lew, B. Ross, Q. Wang, K. Chun, Lydia Wolfe, D. Babusis, Yeojin Park, Kirsten M. Stray, Iva Trancheva, Joy Y. Feng, O. Barauskas, Yili Xu, Pamela Wong, Molly R. Braun, M. Flint, L. McMullan, Shan-Shan Chen, R. Fearns, S. Swaminathan, D. Mayers, C. Spiropoulou, William A. Lee, S. Nichol, T. Cihlář, S. Bavari   +61 more
semanticscholar   +1 more source

Pre-Ebola virus disease laboratory system and related challenges in Liberia

African Journal of Laboratory Medicine, 2016
Prior to the Ebola virus disease outbreak in Liberia, the laboratory system was duplicativefragmented and minimally coordinated. The National Reference Laboratory was conceptualisedto address the existing challenges by promoting the implementation of ...
Stephen B. Kennedy, John B. Dogba, Christine L. Wasunna, Philip Sahr, Candace B. Eastman, Fatorma K. Bolay, Gloria T. Mason, Mark W.S. Kieh   +7 more
doaj   +1 more source

Exploiting the Reverse Vaccinology Approach to Design Novel Subunit Vaccine against Ebola Virus

medRxiv, 2020
Ebola virus is a highly pathogenic RNA virus that causes haemorrhagic fever in human. With very high mortality rate, Ebola virus is considered as one of the dangerous viruses in the world.
M. Ullah, Bishajit Sarkar, S. Islam
semanticscholar   +1 more source

Care and COVID 19: Lessons for liberals and neoliberals

Child &Family Social Work, EarlyView., 2023
Abstract Within the liberal political traditions, care is regarded as a private matter, a problem of ethics rather than justice. Social justice is framed as an issue of economics (re/distribution), culture (recognition) and/or politics (representation).
Kathleen Lynch
wiley   +1 more source

Identification of Diaryl-Quinoline Compounds as Entry Inhibitors of Ebola Virus

Viruses, 2018
Ebola virus is the causative agent of Ebola virus disease in humans. The lethality of Ebola virus infection is about 50%, supporting the urgent need to develop anti-Ebola drugs.
Qinghua Cui, Han Cheng, Rui Xiong, Gang Zhang, Ruikun Du, Manu Anantpadma, Robert A. Davey, Lijun Rong   +7 more
doaj   +1 more source

Assessment of Environmental Contamination and Environmental Decontamination Practices within an Ebola Holding Unit, Freetown, Sierra Leone. [PDF]

PLoS ONE, 2015
Evidence to inform decontamination practices at Ebola holding units (EHUs) and treatment centres is lacking. We conducted an audit of decontamination procedures inside Connaught Hospital EHU in Freetown, Sierra Leone, by assessing environmental swab ...
Daniel Youkee, Colin S Brown, Paul Lilburn, Nandini Shetty, Tim Brooks, Andrew Simpson, Neil Bentley, Marta Lado, Thaim B Kamara, Naomi F Walker, Oliver Johnson   +10 more
doaj   +1 more source