Results 61 to 70 of about 1,763,176 (361)

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

Viruses, 2019
Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses. This compound is currently under clinical development for the treatment of Ebola virus disease (
E. Tchesnokov, Joy Y. Feng, D. Porter, M. Götte   +3 more
semanticscholar   +1 more source

Characterization of an influenza virus pseudotyped with Ebolavirus glycoprotein [PDF]

, 2018
We have produced a new Ebola virus pseudotype: E-S-FLU, which can be handled in biosafety level-1/2 containment for laboratory analysis. E-S-FLU is a single cycle influenza virus coated with Ebolavirus glycoprotein, and it encodes enhanced green ...
Annaert, Wim, Rijal, Pramila, Schimanski, Lisa, Tharkeshwar, Arun Kumar, Townsend, Alain, Wright, Edward, Xiao, Julie   +6 more
core   +1 more source

Analysis, simulation and optimal control of a SEIR model for Ebola virus with demographic effects [PDF]

Commun. Fac. Sci. Univ. Ank. Ser. A1 Math. Stat. 67 (2018), no. 1, 179--197, 2017
Ebola virus is one of the most virulent pathogens for humans. We present a mathematical description of different Susceptible-Exposed-Infectious-Recovered (SEIR) models. By using mathematical modeling and analysis, the latest major outbreak of Ebola virus in West Africa is described.
arxiv   +1 more source

Viral genomics in Ebola virus research

Nature Reviews Microbiology, 2020
Filoviruses such as Ebola virus continue to pose a substantial health risk to humans. Advances in the sequencing and functional characterization of both pathogen and host genomes have provided a wealth of knowledge to clinicians, epidemiologists and ...
Nicholas Di Paola, M. Sanchez-Lockhart, Xiankun Zeng, J. Kuhn, G. Palacios   +4 more
semanticscholar   +1 more source

Progress in COVID research and developments during pandemic

VIEW, Volume 3, Issue 6, December 2022., 2022
The pandemic respiratory disease COVID‐19 has spread over the globe within a small span of time. Generally, there are two important points are being highlighted and considered towards the successful diagnosis and treatment process. The first point includes the reduction of the rate of infections and the next one is the decrease of the death rate.
Sudheesh K. Shukla, Santanu Patra, Trupti R. Das, Dharmesh Kumar, Anshuman Mishra, Ashutosh Tiwari   +5 more
wiley   +1 more source

A little less aggregation a little more replication: Viral manipulation of stress granules

WIREs RNA, Volume 14, Issue 1, January/February 2023., 2023
Viruses depend entirely on host machinery and therefore aim to conquer the host and defeat its defenses to co‐opt its resources for its own replication. Improved understanding of how viruses counteract host immune responses such as stress granule assembly, detailed here, will inform future antiviral therapeutic strategies.
Matthew J. Brownsword, Nicolas Locker
wiley   +1 more source

Ebola Virus Antibody Prevalence in Dogs and Human Risk

Emerging Infectious Diseases, 2005
During the 2001–2002 outbreak in Gabon, we observed that several dogs were highly exposed to Ebola virus by eating infected dead animals. To examine whether these animals became infected with Ebola virus, we sampled 439 dogs and screened them by Ebola ...
Loïs Allela, Olivier Bourry, Régis Pouillot, André Délicat, Philippe Yaba, Brice Kumulungui, Pierre Rouquet, Jean-Paul Gonzalez, Eric M. Leroy   +8 more
doaj   +1 more source

Role of Natural Killer Cells in Innate Protection against Lethal Ebola Virus Infection [PDF]

, 2004
Ebola virus is a highly lethal human pathogen and is rapidly driving many wild primate populations toward extinction. Several lines of evidence suggest that innate, nonspecific host factors are potentially critical for survival after Ebola virus ...
Aman, M. Javad, Bavari, Sina, Bosio, Catharine M., Deal, Emily M., Perkins, Jeremy G., Swenson, Dana L., Warfield, Kelly L., Yokoyama, Wayne M., Young, Howard A.   +8 more
core   +4 more sources

Emergence of Zaire Ebola virus disease in Guinea.

New England Journal of Medicine, 2014
In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea.
S. Baize, D. Pannetier, Lisa Oestereich, Toni Rieger, L. Koivogui, N. Magassouba, B. Soropogui, M. S. Sow, Sakoba Keïta, Hilde de Clerck, A. Tiffany, G. Domínguez, M. Loua, Alexis Traoré, Moussa Kolié, E. Malano, Emmanuel Heleze, Anne Bocquin, S. Mély, H. Raoul, V. Caro, D. Cadar, Martin Gabriel, Meike Pahlmann, D. Tappe, J. Schmidt-Chanasit, B. Impouma, A. Diallo, P. Formenty, M. van Herp, S. Günther   +30 more
semanticscholar   +1 more source

Identification of interferon-stimulated genes that attenuate Ebola virus infection

Nature Communications, 2020
The West Africa Ebola outbreak was the largest outbreak ever recorded, with over 28,000 reported infections; this devastating epidemic emphasized the need to understand the mechanisms to counteract virus infection. Here, we screen a library of nearly 400
M. Kuroda, P. Halfmann, Lindsay Hill-Batorski, M. Ozawa, Tiago J. S. Lopes, G. Neumann, J. Schoggins, C. Rice, Y. Kawaoka   +8 more
semanticscholar   +1 more source