High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo [PDF]
, 2016 Background Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest that circulation of EBOV in human population is common in sub- Saharan Africa.
Afounde, Afongenda +8 more
core +1 more source
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The membrane fusion proteins of viral pathogens as diverse in their replication strategies as coronaviruses and filoviruses depend, for their functional activity, on proteolytic processing during cell entry.
Yuan-Lin Kang +10 more
semanticscholar +2 more sources
Assessment of healthcare worker protocol deviations and self-contamination during personal protective equipment donning and doffing [PDF]
, 2017 OBJECTIVETo evaluate healthcare worker (HCW) risk of self-contamination when donning and doffing personal protective equipment (PPE) using fluorescence and MS2 bacteriophage.DESIGNProspective pilot study.SETTINGTertiary-care hospital.PARTICIPANTSA total ...
Burnham, Carey-Ann D +10 more
core +2 more sources
Newly discovered ebola virus associated with hemorrhagic fever outbreak in Uganda.
PLoS Pathogens, 2008 Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case.
Jonathan S Towner +17 more
doaj +1 more source
Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors. [PDF]
, 2016 Robust humoral and cellular immunity are critical for survival in humans during an ebolavirus infection. However, the interplay between these two arms of immunity is poorly understood.
Cose, Stephen +14 more
core +2 more sources
Tropical Medicine &International Health, EarlyView.ABSTRACT Objectives The 2022 outbreak of Sudan ebolavirus in central Uganda was the country's largest in two decades. It was accompanied by reports of stigma towards affected individuals, households and communities. The objectives of this study were to (1) describe how Ebola disease stigma emerged and manifested during the 2022 Sudan ebolavirus ...
Amy Paterson +9 more
wiley +1 more source
Vox Sanguinis, EarlyView.Abstract Background and Objectives The coronavirus disease 2019 (COVID‐19) pandemic necessitated various therapeutic approaches, including convalescent plasma (CP) administration. The administration timing of COVID‐19 CP (CCP), antibody specificity and quantity were identified as crucial factors for therapeutic success.
Sandra Laner‐Plamberger +9 more
wiley +1 more source
Selection of Filovirus Isolates for Vaccine Development Programs
Vaccines, 2021 The continuing outbreaks of ebola virus disease highlight the ongoing threat posed by filoviruses. Fortunately, licensed vaccines and therapeutics are now available for Zaire ebolavirus.
Daniel N. Wolfe +6 more
doaj +1 more source
Ebola Virus Localization in the Macaque Reproductive Tract during Acute Ebola Virus Disease. [PDF]
, 2018 Sexual transmission of Ebola virus (EBOV) has been demonstrated more than a year after recovery from the acute phase of Ebola virus disease (EVD). The mechanisms underlying EBOV persistence and sexual transmission are not currently understood.
Bernbaum, John G. +7 more
core +1 more source
Treatment of Marburg and Ebola hemorrhagic fevers: A strategy for testing new drugs and vaccines under outbreak conditions. [PDF]
, 2008 The filoviruses, Marburg and Ebola, have the dubious distinction of being associated with some of the highest case-fatality rates of any known infectious disease-approaching 90% in many outbreaks.
A.G. Sprecher +105 more
core +2 more sources