Results 91 to 100 of about 13,687 (277)

Nicotiana benthamiana as a Source of Cowpea Mosaic Virus‐Derived Particles That Specifically Package Designer RNAs

Plant Biotechnology Journal, Volume 24, Issue 1, Page 159-170, January 2026.
ABSTRACT The coupling of replication and encapsidation in the bipartite plant virus, cowpea mosaic virus (CPMV), has been used to specifically incorporate designer RNA molecules into viral particles via transient expression in Nicotiana benthamiana. This is achieved by placing the desired RNA sequence between the 5′ and 3′ UTRs of CPMV RNA‐2 so that ...
H. Peyret, S. N. Shah, Y. Meshcheriakova, J.‐W. Jung, K. Saunders, G. P. Lomonossoff   +5 more
wiley   +1 more source

Assessment of healthcare worker protocol deviations and self-contamination during personal protective equipment donning and doffing [PDF]

, 2017
OBJECTIVETo evaluate healthcare worker (HCW) risk of self-contamination when donning and doffing personal protective equipment (PPE) using fluorescence and MS2 bacteriophage.DESIGNProspective pilot study.SETTINGTertiary-care hospital.PARTICIPANTSA total ...
Burnham, Carey-Ann D, Cass, Candice, Dubberke, Erik R, Fraser, Victoria J, Hink, Tiffany, Kwon, Jennie H, Liang, Stephen Y, Reske, Kimberly A, Seiler, Sondra, Shupe, Angela, Wallace, Meghan A   +10 more
core   +2 more sources

Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus

Science
Obeldesivir (ODV, GS-5245) is an orally administered prodrug of the parent nucleoside of remdesivir (RDV) and is presently in phase 3 trials for COVID-19 treatment.
R. Cross, Courtney Woolsey, Victor C. Chu, D. Babusis, R. Bannister, Meghan S. Vermillion, R. Geleziunas, K. Barrett, Elaine Bunyan, Anh-Quan Nguyen, T. Cihlář, D. Porter, A. Prasad, D. Deer, V. Borisevich, K. Agans, Jasmine Martinez, Mack B. Harrison, Natalie S. Dobias, Karla A. Fenton, J. Bilello, T. Geisbert   +21 more
semanticscholar   +1 more source

Ebola Virus Localization in the Macaque Reproductive Tract during Acute Ebola Virus Disease. [PDF]

, 2018
Sexual transmission of Ebola virus (EBOV) has been demonstrated more than a year after recovery from the acute phase of Ebola virus disease (EVD). The mechanisms underlying EBOV persistence and sexual transmission are not currently understood.
Bernbaum, John G., Hagen, Katie R., Holbrook, Michael R., Huzella, Louis M., Jahrling, Peter B., Johnson, Reed F., Perry, Donna L., Schnell, Matthias J.   +7 more
core   +1 more source

Correspondence of Neutralizing Humoral Immunity and CD4 T Cell Responses in Long Recovered Sudan Virus Survivors. [PDF]

, 2016
Robust humoral and cellular immunity are critical for survival in humans during an ebolavirus infection. However, the interplay between these two arms of immunity is poorly understood.
Cose, Stephen, Dye, John M, Egesa, Moses, Eskira, Yael, Fedida-Metula, Shlomit, Herbert, Andrew S, Kuehne, Ana I, Lewis, Eli C, Lobel, Leslie, Lutwama, Julius Julian, Ochayon, David E, Sobarzo, Ariel, Stonier, Spencer W, Tali, Neta, Yavelsky, Victoria   +14 more
core   +2 more sources

Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region

PLoS Pathogens, 2022
The three human pathogenic ebolaviruses: Zaire (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) virus, cause severe disease with high fatality rates. Epitopes of ebolavirus glycoprotein (GP) recognized by antibodies with binding breadth for all three ...
Clara T. Schoeder, P. Gilchuk, Amandeep K. Sangha, K. Ledwitch, Delphine C. Malherbe, Xuan Zhang, E. Binshtein, Lauren E. Williamson, Cristina E. Martina, Jinhui Dong, Erica Armstrong, Rachel E. Sutton, Rachel S. Nargi, Jessica Rodriguez, N. Kuzmina, B. Fiala, N. King, A. Bukreyev, J. Crowe, J. Meiler   +19 more
semanticscholar   +1 more source

Virological diagnosis of Ebolavirus infection

Pathology, 2015
Ebolaviruses, and the other viral causes of haemorrhagic fevers (VHF) have always posed special problems for diagnostic laboratories. These arise from the rarity of human infections, minimal documented experience with test delivery and interpretation, the paucity of established commercial or in-house assays, the lack of clinical material for test ...
Smith, D.W., Rawlinson, W.D., Kok, J., Dwyer, D.E., Catton, M.   +4 more
openaire   +2 more sources

Characterization of Ebolavirus regulatory genomic regions [PDF]

Virus Research, 2009
For filoviruses, such as Ebolavirus and the closely related Marburgvirus, transcriptional regulation is poorly understood. The open reading frames (ORFs) that encode the viral proteins are separated by regulatory regions composed of the 3' nontranslated region (NTR) of the upstream gene, highly conserved transcription stop and start signals, and the 5 ...
Gabriele, Neumann, Shinji, Watanabe, Yoshihiro, Kawaoka   +2 more
openaire   +2 more sources

Causal Associations Between 4907 Circulating Proteins and Hyperlipidemia: A Two‐Sample Mendelian Randomization Study Based on European Ancestry

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Objective This study employed Mendelian randomization (MR) to investigate the causal relationships between 4907 circulating proteins and hyperlipidemia, with the aim of identifying potential drug targets. Methods Instrumental variables were derived from genome‐wide association study (GWAS) data on 4907 circulating proteins ...
Hui Cheng, Dayuan Zhong
wiley   +1 more source

Putative endogenous filovirus VP35-like protein potentially functions as an IFN antagonist but not a polymerase cofactor. [PDF]

PLoS ONE, 2017
It has been proposed that some non-retroviral RNA virus genes are integrated into vertebrate genomes. Endogenous filovirus-like elements (EFLs) have been discovered in some mammalian genomes.
Tatsunari Kondoh, Rashid Manzoor, Naganori Nao, Junki Maruyama, Wakako Furuyama, Hiroko Miyamoto, Asako Shigeno, Makoto Kuroda, Keita Matsuno, Daisuke Fujikura, Masahiro Kajihara, Reiko Yoshida, Manabu Igarashi, Ayato Takada   +13 more
doaj   +1 more source