Results 111 to 120 of about 11,443 (200)

Testing New Hypotheses Regarding Ebolavirus Reservoirs

Viruses, 2016
Despite a relatively long search for the origin of ebolaviruses, their reservoirs remain elusive. Researchers might have to consider testing alternative hypotheses about how these viruses persist and emerge to advance ebolavirus research.
Siv Aina Jensen Leendertz
doaj   +1 more source

Standardization of the Filovirus Plaque Assay for Use in Preclinical Studies

Viruses, 2012
The filovirus plaque assay serves as the assay of choice to measure infectious virus in a cell culture, blood, or homogenized tissue sample. It has been in use for more than 30 years and is the generally accepted assay used to titrate virus in samples ...
Gene G. Olinger, Ana Kuehne, Jennifer L. Audet, Kendra J. Alfson, Anthony Griffiths, Holly A. Bloomfield, Elizabeth E. Zumbrun, Ashley E. Keeney, Julia E. Biggins, Amy C. Shurtleff, Sina Bavari   +10 more
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Computational prediction and identification of miRNAs in ssRNA viruses [PDF]

, 2014
MiRNAs are conserved endogenous small non-​coding RNA mols. play a very important role in posttranscriptional regulation of gene by binding to mRNA.miRNAs have been identified in plants, animals, invertebrates and even in viruses.
Padmashree, D., Ramachandra Swamy, N.
core  

Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa. [PDF]

, 2020
Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus ...
Amara, Emmanuel, Amman, Brian R, Bairoh, Fatmata V, Bakarr, Ibrahim A, Bangura, Abdulai A, Bangura, Camilla, Bangura, Doris, Bangura, James, Belaganahalli, Manjunatha, Bird, Brian H, Chow, Andrew, Conteh, Immah, Coomber, Moinya, Dhanota, Jasjeet, Edwin, Lavalie, Foday, Ibrahim, Gbakima, Aiah A, Gibson, Alexandra, Goldstein, Tracey, Graziano, James, Guetiya Wadoum, Raoul Emeric, Jambai, Amara, Johnny, Jonathan, Kamanda, Emmanuel S, Kamara, Sorie M, Kanu, Marilyn, Kanu, Osman, Kargbo, Dickson, Koroma, Alusine H, Lebbie, Aiah, Lungai, Victor, Mazet, Jonna AK, Mereweather-Thompson, Vanessa, Musa, Jonathan, Nichol, Stuart T, Ontiveros, Victoria, Osborne, Augustus, Patel, Ketan, Robert, Willie, Saidu, Emmanuel, Schuh, Amy J, Sealy, Tara K, Singh, Tushar, Taboy, Celine H, Towner, Jonathan S, Tremeau-Bravard, Alexandre, Turay, Joseph, Turay, Mohamed, Wadsworth, Richard, Williams, Samuel Maxwell Tom   +49 more
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Discovery of an Ebolavirus-Like Filovirus in Europe

PLoS Pathogens, 2011
Filoviruses, amongst the most lethal of primate pathogens, have only been reported as natural infections in sub-Saharan Africa and the Philippines. Infections of bats with the ebolaviruses and marburgviruses do not appear to be associated with disease.
Negredo, Anabel, Palacios, Gustavo, Vazquez-Moron, Sonia, González, Félix, Dopazo, Hernán, Molero-Sanz, Francisca, Juste, Javier, Quetglas, Juan, Savji, Nazir, de la Cruz Martínez, Maria, Herrera, Jesus Enrique, Pizarro, Manuel, Hutchison, Stephen K, Echevarria, Juan Emilio, Lipkin, W Ian, Tenorio, Antonio   +15 more
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Generalidades de la familia Filoviridae y el virus del Ébola: una actualización de sus implicaciones en la población humana

, 2020
Characteristics of the family Filoviridae and the Ebola virus: an update of its implications in the human population The family Filoviridae is integrated by a group of filamentous RNA viruses that cause severe hemorrhagic fevers in primates and other ...
Burgueño-Sosa, E., Esquivel Gómez, L., León-López, A., Rivadeneyra-Gutiérrez, E.   +3 more
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Amiodarone and metabolite MDEA inhibit Ebola virus infection by interfering with the viral entry process [PDF]

, 2017
Ebola virus disease (EVD) is one of the most lethal transmissible infections characterized by a high fatality rate, and a treatment has not been developed yet.
Baritussio, Aldo, Bigler, Laurent, Calistri, Arianna, Fabris, Fabrizio, Garzino-Demo, Alfredo, Ha, Huy Riem, Mirazimi, Ali, Munegato, Denis, Palù, Giorgio, Parolin, Cristina, Salata, Cristiano   +10 more
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Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies.

PLoS Pathogens
Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance.
Ariel S Wirchnianski, Elisabeth K Nyakatura, Andrew S Herbert, Ana I Kuehne, Shawn A Abbasi, Catalina Florez, Nadia Storm, Lindsay G A McKay, Leandrew Dailey, Erin Kuang, Dafna M Abelson, Anna Z Wec, Srinjoy Chakraborti, Frederick W Holtsberg, Sergey Shulenin, Zachary A Bornholdt, M Javad Aman, Anna N Honko, Anthony Griffiths, John M Dye, Kartik Chandran, Jonathan R Lai   +21 more
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Immunotherapeutics for Ebola Virus Disease: Hope on the Horizon

Biologics: Targets & Therapy, 2021
Kyle L O’Donnell, Andrea Marzi Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USACorrespondence: Andrea Marzi Email marzia@niaid.nih ...
O'Donnell KL, Marzi A
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Early human B cell response to Ebola virus in four U.S. survivors of infection [PDF]

, 2019
The human B cell response to natural filovirus infections early after recovery is poorly understood. Previous serologic studies suggest that some Ebola virus survivors exhibit delayed antibody responses with low magnitude and quality.
Bombardi, Robin, Branchizio, Andre, Crowe, James E., Jr., Davidson, Edgar, Doranz, Benjamin J., Flyak, Andrew I., Fusco, Marnie L., Glass, Pamela J., Halfmann, Peter J., Kawaoka, Yoshihiro, Kose, Nurgun, Piper, Ashley E., Reddy, Srikar, Saphire, Erica O., Williamson, Lauren E.   +14 more
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