Results 111 to 120 of about 12,924 (266)

Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines

Pathogens, 2022
Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu, Jessica M. Gullett, Thirumala-Devi Kanneganti   +2 more
doaj   +1 more source

Visualisierung aktiver Zentren in elektrogesponnenen photoaktiven Membranen mittels Fluoreszenz‐Lebensdauer‐Bildgebung

Angewandte Chemie, Volume 136, Issue 50, December 9, 2024.
In dieser Studie wurden durch Elektrospinning photoaktive Membranen aus hydrophobem PCL und hydrophilem PAN hergestellt, in die entweder ein hydrophober oder hydrophiler Photosensibilisator eingebettet wurde. Mit Hilfe der Fluoreszenzlebensdauer‐Mikroskopie konnten photoangeregte „aktive Zentren“ innerhalb der Membranen identifiziert werden und damit ...
Fabian Terlau, Hanna M. Martin, Anzhela Galstyan   +2 more
wiley   +1 more source

High prevalence of IgG antibodies to Ebola virus in the Efé pygmy population in the Watsa region, Democratic Republic of the Congo [PDF]

, 2016
Background Factors related to the natural transmission of Ebola virus (EBOV) to humans are still not well defined. Results of previous sero-prevalence studies suggest that circulation of EBOV in human population is common in sub- Saharan Africa.
Afounde, Afongenda, Borchert, Matthias, Kulidri, Amayo, Mulangu, Sabue, Muyembe-Tamfum, Jean-Jacques, Paweska, Janusz, Swanepoel, Robert, Tshomba, Antoine, Van der Stuyft, Patrick   +8 more
core   +1 more source

Regioselective Deacetylation in Nucleosides and Derivatives

ChemBioChem, Volume 25, Issue 23, December 2, 2024.
Selective deprotection of the acetyl group(s) in acetylated nucleosides demonstrates practical significance in synthetic processes. It simplifies the preparation of partially or differentially substituted nucleoside intermediates. In this mini‐review, we summarized and evaluated recent approaches for regioselective deacetylation in acetylated ...
Charis Grabbe, Li Cai
wiley   +1 more source

The current landscape of nucleic acid tests for filovirus detection. [PDF]

, 2018
Nucleic acid testing (NAT) for pathogenic filoviruses plays a key role in surveillance and to control the spread of infection. As they share clinical features with other pathogens, the initial spread of these viruses can be misdiagnosed.
Agnandji, Agnandji, Al-Soud, Al-Soud, Andrew D. Sails, Benzine, Bergqvist, Biek, Boyd, Cai, Carinelli, Chua, Chughtai, Cnops, David J. Clark, De Santis, Deen, Drosten, Duy, Dye, Ewer, FDA, Gay-Andrieu, Geisbert, Gibb, Greninger, Haddock, Hayman, Henao-Restrepo, Henry M. Staines, Huttner, Jayme, John Tyson, Kibuuka, Koehler, Kurosaki, Kurosaki, Kurosaki, Laing, Ledgerwood, Leroy, Leroy, Leski, Loftis, Lu, Mate, Milligan, Ogawa, Ogawa, Oloniniyi, Park, Pattyn, Pettitt, Pinsky, Pourrut, Pyankov, Quick, Raftery, Regules, Rieger, Rodriguez, Rossi, Sanchez, Sanjeev Krishna, Schrader, Semper, Shah, Southern, Spengler, Swanepoel, Tapia, Towner, Towner, Trombley, Varkey, Waxman, Weidmann, Weingartl, Weller, WHO, WHO, Wong, Woolhouse, Xu, Zheng, Zhu   +85 more
core   +1 more source

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.
Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier, Viktoria M. S. Kjær, Stephen Griffin, Birthe B. Kragelund, Mette M. Rosenkilde   +4 more
wiley   +1 more source

Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein [PDF]

Journal of Virology, 2018
ABSTRACT We have produced a new Ebola virus pseudotype, E-S-FLU, that can be handled in biosafety level 1/2 containment for laboratory analysis. The E-S-FLU virus is a single-cycle influenza virus coated with Ebolavirus glycoprotein, and it encodes enhanced green fluorescence protein as a reporter that replaces the influenza ...
Wim Annaert, Edward Wright, Alain Townsend, Lisa Schimanski, Pramila Rijal, Julie Huiyuan Xiao, Arun Kumar Tharkeshwar   +6 more
openaire   +3 more sources

Structural Basis for Differential Neutralization of Ebolaviruses

Viruses, 2012
There are five antigenically distinct ebolaviruses that cause hemorrhagic fever in humans or non-human primates (Ebola virus, Sudan virus, Reston virus, Taï Forest virus, and Bundibugyo virus).
John M. Dye, Erica Ollmann Saphire, Kartik Chandran, Virgil L. Woods, Sheng Li, Tong Liu, Ana I. Keuhne, Anthony C. Wong, Marnie L. Fusco, Takao Hashiguchi, Shridhar Bale, Joao M. Dias   +11 more
doaj   +1 more source

Data Fitting and Scenario Analysis of Vaccination in the 2014 Ebola Outbreak in Liberia [PDF]

Osong Public Health and Research Perspectives, 2019
Objectives This study aimed to extend an epidemiological model (SEIHFR) to analyze epidemic trends, and evaluate intervention efficacy. Methods SEIHFR was modified to examine disease transmission dynamics after vaccination for the Ebola outbreak.
Zhifu Xie
doaj   +1 more source

Introducing EbolaCheck: potential for point-of-need infectious disease diagnosis [PDF]

, 2015
The 2013–2015 Ebolavirus disease humanitarian crisis has spurred the development of laboratory-free, point-of-care nucleic acid testing solutions.
Christie A, Mather ST, Moreau M, Pasloske BL, Regules JA, Spengler JR, Sterghios Athanasios Moschos   +6 more
core   +1 more source