Results 111 to 120 of about 12,943 (270)
Rapid Sequence Identification of Potential Pathogens Using Techniques from Sparse Linear Algebra
, 2015 The decreasing costs and increasing speed and accuracy of DNA sample collection, preparation, and sequencing has rapidly produced an enormous volume of genetic data. However, fast and accurate analysis of the samples remains a bottleneck. Here we present
Chiu, Nelson +4 more
core +1 more source
Taï Forest Virus Does Not Cause Lethal Disease in Ferrets
Microorganisms, 2021 Filoviruses are zoonotic, negative-sense RNA viruses, most of which are capable of causing severe disease in humans and nonhuman primates, often with high case fatality rates.
Zachary Schiffman +8 more
doaj +1 more source
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi +9 more
wiley +1 more source
Characterization of Sudan Ebolavirus infection in ferrets
Oncotarget, 2017 Sudan virus (SUDV) outbreaks in Africa are highly lethal; however, the development and testing of novel antivirals and vaccines for this virus has been limited by a lack of suitable animal models. Non-human primates (NHP) remain the gold standard for modeling filovirus disease, but they are not conducive to screening large numbers of experimental ...
Andrea Kroeker +11 more
openaire +3 more sources
Replication-Deficient Ebolavirus as a Vaccine Candidate [PDF]
Journal of Virology, 2009 ABSTRACT Ebolavirus causes severe hemorrhagic fever, with case fatality rates as high as 90%. Currently, no licensed vaccine is available against Ebolavirus. We previously generated a replication-deficient, biologically contained Ebolavirus, EbolaΔVP30, which lacks the essential VP30 gene, grows only in cells stably expressing ...
Shinji Watanabe +11 more
openaire +3 more sources
Filoviruses: Innate Immunity, Inflammatory Cell Death, and Cytokines
Pathogens, 2022 Filoviruses are a group of single-stranded negative sense RNA viruses. The most well-known filoviruses that affect humans are ebolaviruses and marburgviruses. During infection, they can cause life-threatening symptoms such as inflammation, tissue damage,
Jianlin Lu +2 more
doaj +1 more source
Predictive and comparative analysis of Ebolavirus proteins [PDF]
Cell Cycle, 2015 Ebolavirus is the pathogen for Ebola Hemorrhagic Fever (EHF). This disease exhibits a high fatality rate and has recently reached a historically epidemic proportion in West Africa. Out of the 5 known Ebolavirus species, only Reston ebolavirus has lost human pathogenicity, while retaining the ability to cause EHF in long-tailed macaque.
Nick V. Grishin, Qian Cong, Jimin Pei
openaire +3 more sources
Testing New Hypotheses Regarding Ebolavirus Reservoirs
Viruses, 2016 Despite a relatively long search for the origin of ebolaviruses, their reservoirs remain elusive. Researchers might have to consider testing alternative hypotheses about how these viruses persist and emerge to advance ebolavirus research.
Siv Aina Jensen Leendertz
doaj +1 more source
Development and Structural Analysis of Antibody Therapeutics for Filoviruses
Pathogens, 2022 The filoviruses, including ebolaviruses and marburgviruses, are among the world’s deadliest pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is the focus of current therapeutic monoclonal antibody discovery efforts.
Xiaoying Yu, Erica Ollmann Saphire
doaj +1 more source
ACR Open Rheumatology, Volume 7, Issue 1, January 2025.Objective Idiopathic inflammatory myopathies (IIMs) are a group of heterogeneous, systemic autoimmune diseases characterized by specific clinical features and, frequently, skeletal muscle inflammation. Specific subtypes of IIMs can be characterized by myositis‐specific autoantibodies and are associated with distinct clinical phenotypes.
Sahana Jayaraman +5 more
wiley +1 more source