Results 121 to 130 of about 13,687 (277)

Land Use Change and Infectious Disease Emergence

Reviews of Geophysics, Volume 63, Issue 2, June 2025.
Abstract Major infectious diseases threatening human health are transmitted to people from animals or by arthropod vectors such as insects. In recent decades, disease outbreaks have become more common, especially in tropical regions, including new and emerging infections that were previously undetected or unknown. Even though there is growing awareness
M. Cristina Rulli, Paolo D’Odorico, Nikolas Galli, Reju S. John, Renata L. Muylaert, Monia Santini, David T. S. Hayman   +6 more
wiley   +1 more source

Potential Vaccines and Post-Exposure Treatments for Filovirus Infections

Viruses, 2012
Viruses of the family Filoviridae represent significant health risks as emerging infectious diseases as well as potentially engineered biothreats. While many research efforts have been published offering possibilities toward the mitigation of filoviral ...
Gene G. Olinger, Brian M. Friedrich, John C. Trefry, Lisa E. Hensley, Anna N. Honko, Darci R. Smith, Julia E. Biggins   +6 more
doaj   +1 more source

A broadly-neutralizing antibody against Ebolavirus glycoprotein that potentiates the breadth and neutralization potency of other antibodies

bioRxiv
Ebolavirus disease (EVD) is caused by multiple species of Ebolavirus. Monoclonal antibodies (mAbs) against the virus glycoprotein (GP) are the only class of therapeutic approved for treatment of EVD caused by Zaire ebolavirus (EBOV).
F. Donnellan, V. Rayaprolu, P. Rijal, Victoria O’Dowd, Amar Parvate, Heather M. Callaway, Chitra Hariharan, D. Parekh, S. Hui, K. Shaffer, Ruben Diaz Avalos, K. Hastie, L. Schimanski, Helena Müller-Kräuter, Thomas Strecker, Ariane Balaram, P. Halfmann, E. Saphire, D. Lightwood, Alain R. Townsend, S. Draper   +20 more
semanticscholar   +1 more source

Process Intensification for Recombinant Marburg Virus Glycoprotein Production Using Drosophila S2 Cells

Engineering in Life Sciences, Volume 25, Issue 5, May 2025.
ABSTRACT Marburg marburgvirus (MARV) is a highly virulent human pathogen with limited therapeutic options. Recombinant MARV glycoprotein (GP) produced in Drosophila Schneider 2 (S2) cells has been extensively investigated as potential vaccine antigen with promising efficacy demonstrated in nonhuman primate models.
Sven Göbel, Ludwig Mayerlen, Isabelle Yazel Eiser, Lisa Fichtmueller, David Clements, Udo Reichl, Yvonne Genzel, AxelT. Lehrer   +7 more
wiley   +1 more source

Marburg Virus Disease: A Narrative Review

Health Science Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background and Aims Given the recent deadly outbreaks of the Marburg virus (MARV), in early 2023 in Tanzania and Equatorial Guinea, and the most recent one in Rwanda in 2024, there has been renewed attention across Africa on the threat posed by the re‐emergence of MARV as a growing concern for public health.
Arash Letafati, Somayeh Sadat Hosseini Fakhr, Ali Qaraee Najafabadi, Negin Karami, Hassan Karami   +4 more
wiley   +1 more source

A Bayesian analysis of birth pulse effects on the probability of detecting Ebola virus in fruit bats

Peer Community Journal
Since 1976 various species of Ebolavirus have caused a series of zoonotic outbreaks and public health crises in Africa. Bats have long been hypothesised to function as important hosts for ebolavirus maintenance, however the transmission ecology for these
Pleydell, David R.J., Ndong Bass, Innocent, Mba Djondzo, Flaubert Auguste, Meta Djomsi, Dowbiss, Kouanfack, Charles, Peeters, Martine, Cappelle, Julien   +6 more
doaj   +1 more source

RNA binding motif 4 inhibits the replication of ebolavirus by directly targeting 3′-leader region of genomic RNA

Emerging Microbes and Infections
Ebola virus (EBOV) belongs to Filoviridae family possessing single-stranded negative-sense RNA genome, which is a serious threat to human health. Nowadays, no therapeutics have been proven to be successful in efficiently decreasing the mortality rate ...
Linjin Fan, Yulong Wang, Hongxin Huang, Zequn Wang, Chudan Liang, Xiaofeng Yang, Pengfei Ye, Jingyan Lin, Wendi Shi, Yuandong Zhou, Huijun Yan, Zhenyu Long, Zhongyi Wang, Linna Liu, Jun Qian   +14 more
semanticscholar   +1 more source

Factores pronósticos clínicos determinantes en la supervivencia de pacientes con el virus Ébola

Revista Cubana de Medicina Militar, 2020
Introducción: La enfermedad por el virus del Ébola presenta una elevada letalidad, por lo cual resulta de gran interés la realización de investigaciones que aborden las manifestaciones clínicas que pudieran ser factores pronósticos de supervivencia ...
Osvaldo Miranda Gómez, Carlos Manuel Castro Baras, Yoel Alberto Fleites Alonso, José Eduardo Díaz Gómez, Yanetsi Contreras Olive, Sara Anneris Urgellés Carrera   +5 more
doaj   +2 more sources

Risk assessment of Ebola Reston virus in humans in the Philippines

Western Pacific Surveillance and Response, 2019
Objective: There have been five documented outbreaks of Ebola Reston virus (RESTV) in animals epidemiologically linked to the Philippines. This assessment was conducted to determine the risk of RESTV occurring in humans in the Philippines and its ...
Johnette A Peñas, Mary Elizabeth Miranda, Vikki Carr de los Reyes, Ma. Nemia L Sucaldito, Rio L Magpantay   +4 more
doaj   +1 more source

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source