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Immune Evasion in Ebolavirus Infections
Viral Immunology, 2015Ebola virus (EBOV) infects humans as well as several animal species. It can lead to a highly lethal disease, with mortality rates approaching 90% in primates. Recent advances have deepened our understanding of how this virus is able to prevent the development of protective immune responses.
Jonathan, Audet, Gary P, Kobinger
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2020
Prior to the discovery of the Reston ebolavirus (RESTV) in 1989, filoviruses were thought to be present only in Africa. The virus was discovered in a quarantine facility in Reston, Virginia, USA, following the deaths of imported cynomolgus macaques (Macaca fascicularis) from the Philippines displaying severe haemorrhagic disease.
Ina L. Smith +2 more
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Prior to the discovery of the Reston ebolavirus (RESTV) in 1989, filoviruses were thought to be present only in Africa. The virus was discovered in a quarantine facility in Reston, Virginia, USA, following the deaths of imported cynomolgus macaques (Macaca fascicularis) from the Philippines displaying severe haemorrhagic disease.
Ina L. Smith +2 more
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Peptides for Anti-Ebolavirus Vaccines
Current Drug Discovery Technologies, 2016Two main factors can affect the development of ebolavirus immunotherapeutics: the vast peptide commonality between ebolavirus and human proteins, and the high rate of spontaneous mutation of ebolavirus within its human host. Indeed, the viral versus human peptide overlap may represent a relevant source of autoimmune crossreactions following vaccination,
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ELISA Methods for the Detection of Ebolavirus Infection
2017Ebola viruses are high-priority pathogens first discovered in rural Africa associated with sporadic outbreaks of severe hemorrhagic disease in humans and nonhuman primates. Little is known about the disease ecology or the prevalence of past exposure of human populations to any of the five species of the genus Ebolavirus. The use of immunologic means of
Robert W, Cross, Thomas G, Ksiazek
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Ebolavirus: An Overview of Molecular and Clinical Pathogenesis
2017Ebolaviruses cause severe, often fatal hemorrhagic fever in Central, East, and West Africa. Until recently, they have been viewed as rare but highly pathogenic infections with regional, but limited, global public health impact. This view has changed with the emergence of the first epidemic of Ebola hemorrhagic fever in West Africa.
Veronica, Vine +2 more
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Characterization of Ebolavirus Entry
2019Ebola virus disease is a global concern given its periodic occurrence, high lethality, and rapid spread, coupled with a lack of approved therapeutics and vaccines. New tools are needed to gain fundamental insight into the virus life cycle, particularly entry and fusion of the viral envelope with the host membrane, and to combat the spread of the ...
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Pan-ebolavirus protective therapy by two multifunctional human antibodies
Cell, 2021Robert Carnahan +2 more
exaly
Virus kinetics and biochemical derangements among children with Ebolavirus disease
EClinicalMedicine, 2022Michael Hawkes +2 more
exaly