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Immune Evasion in Ebolavirus Infections
Viral Immunology, 2015Ebola virus (EBOV) infects humans as well as several animal species. It can lead to a highly lethal disease, with mortality rates approaching 90% in primates. Recent advances have deepened our understanding of how this virus is able to prevent the development of protective immune responses.
Jonathan, Audet, Gary P, Kobinger
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2020
Prior to the discovery of the Reston ebolavirus (RESTV) in 1989, filoviruses were thought to be present only in Africa. The virus was discovered in a quarantine facility in Reston, Virginia, USA, following the deaths of imported cynomolgus macaques (Macaca fascicularis) from the Philippines displaying severe haemorrhagic disease.
Ina L. Smith +2 more
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Prior to the discovery of the Reston ebolavirus (RESTV) in 1989, filoviruses were thought to be present only in Africa. The virus was discovered in a quarantine facility in Reston, Virginia, USA, following the deaths of imported cynomolgus macaques (Macaca fascicularis) from the Philippines displaying severe haemorrhagic disease.
Ina L. Smith +2 more
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Peptides for Anti-Ebolavirus Vaccines
Current Drug Discovery Technologies, 2016Two main factors can affect the development of ebolavirus immunotherapeutics: the vast peptide commonality between ebolavirus and human proteins, and the high rate of spontaneous mutation of ebolavirus within its human host. Indeed, the viral versus human peptide overlap may represent a relevant source of autoimmune crossreactions following vaccination,
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Nachrichten aus der Chemie, 2018
AbstractDas Ebolavirus, das vor drei Jahren Westafrika heimsuchte, ist ungewöhnlich in seinem Aufbau und seinen Funktionsmechanismen. Die Strukturforschung beginnt erst jetzt, die Details dieses tödlichen Krankheitserregers zu verstehen.
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AbstractDas Ebolavirus, das vor drei Jahren Westafrika heimsuchte, ist ungewöhnlich in seinem Aufbau und seinen Funktionsmechanismen. Die Strukturforschung beginnt erst jetzt, die Details dieses tödlichen Krankheitserregers zu verstehen.
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Characterization of Ebolavirus Entry
2019Ebola virus disease is a global concern given its periodic occurrence, high lethality, and rapid spread, coupled with a lack of approved therapeutics and vaccines. New tools are needed to gain fundamental insight into the virus life cycle, particularly entry and fusion of the viral envelope with the host membrane, and to combat the spread of the ...
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Zaire ebolavirus spreads across Africa
The Lancet Infectious Diseases, 2005By studying the genetic sequences of ebolaviruses that caused outbreaks in equatorial Africa over the past three decades, a team of German and US researchers has concluded that the Zaire strain of ebolavirus (ZEBOV) has been slowly spreading across these regions rather than popping up as sporadic outbreaks. “Our analyses suggest that ZEBOV has recently
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Ebolavirus i et historisk perspektiv
Ugeskrift for Læger, 2015The 2014 Ebola fever outbreak was the first of its kind in West Africa. This epidemic, affecting multiple countries, by far exceeded any previous outbreak in case counts and geographical spread. But Ebola viruses are not new to Africa, as they have occurred in epidemic proportion in the central part of the continent since 1976.
Sørensen, Linda Løhde +2 more
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