Results 81 to 90 of about 12,455 (266)

Clinical Manifestations and Case Management of Ebola Haemorrhagic Fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008 [PDF]

, 2012
A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%).
A Grolla, A MacNeil, A Tuffs, AJ Georges, AM Casillas, B Jeffs, B Le Guenno, Benjamin Jeffs, BS Hewlett, DG Bausch, DG Bausch, DG Bausch, DG Bausch, DG Bausch, DH Smith, DL Heymann, E Mupere, ED Johnson, EM Leroy, EM Leroy, Esther Sterk, GA Martini, GA Martini, JL Conrad, Joseph Wamala, JS Gear, JS Towner, Julius Lutwama, K Kibadi, K Mupapa, K Mupapa, KJ Davis, M Borchert, M Bray, M Bray, MA Bwaka, Malcolm Gracie Semple, Maria D. Van Kerkhove, Matthias Borchert, ME Miranda, Michel Van Herp, MJ Bonnet, Natasha Howard, NK Jaax, P Formenty, P Formenty, P Francesconi, P Roddy, P Roddy, Paul Roddy, PE Rollin, Pedro Pablo Palma, PH Sureau, R Colebunders, R Ndambi, R Siegert, RC Baron, Robert Colebunders, RT Emond, S Becker, SF Dowell, SP Fisher-Hoch, SR Zaki, TH Roels, U Stroher, Y Kalongi, Zabulon Yoti   +66 more
core   +3 more sources

Ebola virus disease outbreak in Korea: use of a mathematical model and stochastic simulation to estimate risk [PDF]

Epidemiology and Health, 2019
OBJECTIVES According to the World Health Organization, there have been frequent reports of Ebola virus disease (EVD) since the 2014 EVD pandemic in West Africa. We aim to estimate the outbreak scale when an EVD infected person arrives in Korea.
Youngsuk Ko, Seok-Min Lee, Soyoung Kim, Moran Ki, Eunok Jung   +4 more
doaj   +1 more source

Presence and persistence of Ebola or Marburg virus in patients and survivors: A rapid systematic review [PDF]

, 2016
Background: The 2013-15 Ebola outbreak was unprecedented due to sustainedtransmission within urban environments and thousands of survivors. In 2014 the World Health Organization stated that there was insufficient evidence to give definitive guidance ...
Brainard, Julii, Edmunds, Kelly, Hooper, Lee, Hunter, Paul, Pond, Katherine   +4 more
core   +3 more sources

Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus

Science
Obeldesivir (ODV, GS-5245) is an orally administered prodrug of the parent nucleoside of remdesivir (RDV) and is presently in phase 3 trials for COVID-19 treatment.
R. Cross, Courtney Woolsey, Victor C Chu, D. Babusis, R. Bannister, Meghan S. Vermillion, R. Geleziunas, K. Barrett, Elaine Bunyan, Anh-Quan Nguyen, T. Cihlář, D. Porter, A. Prasad, D. Deer, V. Borisevich, K. Agans, Jasmine Martinez, Mack B Harrison, Natalie S. Dobias, Karla A. Fenton, J. Bilello, T. Geisbert   +21 more
semanticscholar   +1 more source

Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The membrane fusion proteins of viral pathogens as diverse in their replication strategies as coronaviruses and filoviruses depend, for their functional activity, on proteolytic processing during cell entry.
Yuan-Lin Kang, Yi-Ying Chou, Paul W. Rothlauf, Zhuoming Liu, Timothy K. Soh, David Cureton, J. Case, Rita E. Chen, M. Diamond, S. Whelan, T. Kirchhausen   +10 more
semanticscholar   +2 more sources

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats [PDF]

, 2015
Biological factors that influence the host range and spillover of Ebola virus (EBOV) and other filoviruses remain enigmatic. While filoviruses infect diverse mammalian cell lines, we report that cells from African straw-colored fruit bats (Eidolon helvum)
Agnarsson, Allison, Almeida, Amman, Amman, Baker, Biesold, Bolger, Carette, Carroll, Carstea, Chandran, Cui, Côté, Daugherty, Deffieu, Delport, Demogines, Demogines, Drexler, Ebihara, Feldmann, Ge, Gire, Grabherr, He, Herbert, Hueffer, Jahrling, Jangra, Jayme, Jones, Kaelber, Kamins, Katzourakis, Krishnan, Kugelman, Kuhn, Kühl, Lee, Leroy, Li, Mali, Maruyama, Meyerson, Miller, Miller, Miller-Butterworth, Murrell, Negredo, Ng, Olival, Park, Parker, Paweska, Peel, Pond, Radoshitzky, Radoshitzky, Raj, Ren, Robertson, Ross, Runz, Ruxton, Sheahan, Swenson, Swenson, Takada, Taylor, Taylor, Taylor, Tong, Towner, Vanier, Volchkov, Wahl-Jensen, Wong, Yang   +78 more
core   +2 more sources

Ebolavirus Classification Based on Natural Vectors [PDF]

DNA and Cell Biology, 2015
According to the WHO, ebolaviruses have resulted in 8818 human deaths in West Africa as of January 2015. To better understand the evolutionary relationship of the ebolaviruses and infer virulence from the relationship, we applied the alignment-free natural vector method to classify the newest ebolaviruses.
Hui Zheng, Tung Hoang, Rong Lucy He, Changchuan Yin, Stephen S.-T. Yau, Jie Yang   +5 more
openaire   +3 more sources

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]

, 2017
Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K, Basler, Christopher F, Batra, Jyoti, Leung, Daisy W, Luthra, Priya, Wu, Chao, Xu, Wei   +6 more
core   +2 more sources

Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies

PLoS Pathogens
Monoclonal antibodies (mAbs) are an important class of antiviral therapeutics. MAbs are highly selective, well tolerated, and have long in vivo half-life as well as the capacity to induce immune-mediated virus clearance.
A. Wirchnianski, E. Nyakatura, A. Herbert, A. Kuehne, Shawn A. Abbasi, Catalina Florez, Nadia Storm, Lindsay G. A. McKay, Leandrew Dailey, Erin A. Kuang, Dafna M. Abelson, Anna Z. Wec, Srinjoy Chakraborti, Frederick W. Holtsberg, S. Shulenin, Z. Bornholdt, M. Aman, A. Honko, Anthony Griffiths, J. Dye, K. Chandran, Jonathan R. Lai   +21 more
semanticscholar   +1 more source

First laboratory confirmation and sequencing of Zaire ebolavirus in Uganda following two independent introductions of cases from the 10th Ebola Outbreak in the Democratic Republic of the Congo, June 2019

PLoS Neglected Tropical Diseases, 2022
Uganda established a domestic Viral Hemorrhagic Fever (VHF) testing capacity in 2010 in response to the increasing occurrence of filovirus outbreaks.
L. Nyakarahuka, S. Mulei, S. Whitmer, Kyondo Jackson, A. Tumusiime, A. Schuh, J. Baluku, Allison Joyce, F. Ocom, J. Tusiime, J. Montgomery, S. Balinandi, J. Lutwama, J. Klena, T. Shoemaker   +14 more
semanticscholar   +1 more source