Results 81 to 90 of about 12,943 (270)

Immunogenicity and safety of ebolavirus vaccines in healthy adults: a systematic review and meta-analysis of randomized controlled trials

Expert Review of Vaccines, 2023
Background This review aimed to systematically evaluate the immunogenicity and safety of the candidate Ebola virus vaccine (EVV). Methods We searched five databases for randomized controlled trials (RCTs) evaluating the effects of EVV on healthy adults ...
Juntao Yin, Liang Zhang, Chaoyang Wang, Changjiang Qin, Mingsan Miao   +4 more
semanticscholar   +1 more source

Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form

Cell Reports, 2021
Summary: The Ebola virus matrix protein VP40 forms distinct structures linked to distinct functions in the virus life cycle. Dimeric VP40 is a structural protein associated with virus assembly, while octameric, ring-shaped VP40 is associated with ...
Sara Landeras-Bueno, Hal Wasserman, Glenn Oliveira, Zachary L. VanAernum, Florian Busch, Zhe Li Salie, Vicki H. Wysocki, Kristian Andersen, Erica Ollmann Saphire   +8 more
doaj   +1 more source

Introducing EbolaCheck: potential for point-of-need infectious disease diagnosis [PDF]

, 2015
The 2013–2015 Ebolavirus disease humanitarian crisis has spurred the development of laboratory-free, point-of-care nucleic acid testing solutions.
Christie A, Mather ST, Moreau M, Pasloske BL, Regules JA, Spengler JR, Sterghios Athanasios Moschos   +6 more
core   +1 more source

Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus

Science
Obeldesivir (ODV, GS-5245) is an orally administered prodrug of the parent nucleoside of remdesivir (RDV) and is presently in phase 3 trials for COVID-19 treatment.
R. Cross, Courtney Woolsey, Victor C Chu, D. Babusis, R. Bannister, Meghan S. Vermillion, R. Geleziunas, K. Barrett, Elaine Bunyan, Anh-Quan Nguyen, T. Cihlář, D. Porter, A. Prasad, D. Deer, V. Borisevich, K. Agans, Jasmine Martinez, Mack B Harrison, Natalie S. Dobias, Karla A. Fenton, J. Bilello, T. Geisbert   +21 more
semanticscholar   +1 more source

Ecological indicators of mammal exposure to Ebolavirus [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2019
Much of the basic ecology of Ebolavirus remains unresolved despite accumulating disease outbreaks, viral strains and evidence of animal hosts. Because human Ebolavirus epidemics have been linked to contact with wild mammals other than bats, traits shared by species that have been infected by Ebolavirus and their phylogenetic distribution could suggest ...
John Paul Schmidt, Sean Maher, John M. Drake, Tao Huang, Maxwell J. Farrell, Barbara A. Han   +5 more
openaire   +4 more sources

Ebolavirus Classification Based on Natural Vectors [PDF]

DNA and Cell Biology, 2015
According to the WHO, ebolaviruses have resulted in 8818 human deaths in West Africa as of January 2015. To better understand the evolutionary relationship of the ebolaviruses and infer virulence from the relationship, we applied the alignment-free natural vector method to classify the newest ebolaviruses.
Hui Zheng, Tung Hoang, Rong Lucy He, Changchuan Yin, Stephen S.-T. Yau, Jie Yang   +5 more
openaire   +3 more sources

Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop

Cell Reports, 2018
Summary: Monoclonal antibodies (mAbs) with pan-ebolavirus cross-reactivity are highly desirable, but development of such mAbs is limited by a lack of a molecular understanding of cross-reactive epitopes.
Charles D. Murin, Jessica F. Bruhn, Zachary A. Bornholdt, Jeffrey Copps, Robyn Stanfield, Andrew B. Ward   +5 more
doaj   +1 more source

<i>Wisteria floribunda</i> agglutinin enhances <i>Zaire ebolavirus</i> entry through interactions at specific <i>N</i>-linked glycosylation sites on the virus glycoprotein complex. [PDF]

J Gen Virol
Entry of Zaire ebolavirus (EBOV) into a host cell is a complex process requiring interactions between the viral glycoproteins (GPs) and cellular factors.
Duncan JD, Pathak M, King BJ, Bamber H, Radford P, Dey J, Richardson C, Astbury S, McClure P, Ball JK, Urbanowicz RA, Tarr AW.   +11 more
europepmc   +2 more sources

Ebola virus disease outbreak in Korea: use of a mathematical model and stochastic simulation to estimate risk [PDF]

Epidemiology and Health, 2019
OBJECTIVES According to the World Health Organization, there have been frequent reports of Ebola virus disease (EVD) since the 2014 EVD pandemic in West Africa. We aim to estimate the outbreak scale when an EVD infected person arrives in Korea.
Youngsuk Ko, Seok-Min Lee, Soyoung Kim, Moran Ki, Eunok Jung   +4 more
doaj   +1 more source

Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma

Frontiers in Immunology, 2021
Three clinically relevant ebolaviruses – Ebola (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) viruses, are responsible for severe disease and occasional deadly outbreaks in Africa.
Pavlo Gilchuk, Adrian Guthals, Stefano R. Bonissone, Jared B. Shaw, Philipp A. Ilinykh, Philipp A. Ilinykh, Kai Huang, Kai Huang, Robin G. Bombardi, Jenny Liang, Ariadna Grinyo, Edgar Davidson, Elaine C. Chen, Bronwyn M. Gunn, Galit Alter, Erica Ollmann Saphire, Benjamin J. Doranz, Alexander Bukreyev, Alexander Bukreyev, Alexander Bukreyev, Larry Zeitlin, Natalie Castellana, James E. Crowe, James E. Crowe, James E. Crowe   +24 more
doaj   +1 more source