Results 81 to 90 of about 12,924 (266)
Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis [PDF]
, 2017 Ebola virus (EBOV) is an enveloped negative-sense RNA virus that causes sporadic outbreaks with high case fatality rates. Ebola viral protein 30 (eVP30) plays a critical role in EBOV transcription initiation at the nucleoprotein (eNP) gene, with ...
Amarasinghe, Gaya K +6 more
core +2 more sources
Potent neutralizing monoclonal antibodies against Ebola virus isolated from vaccinated donors
mAbs, 2020 Ebola virus (EBOV) can cause severe hemorrhagic fever in humans, and no approved treatment is currently available. Although several antibodies have achieved good protection in animal models, the potential emerging isolates of ebolavirus and the unknown ...
Pengfei Fan +12 more
doaj +1 more source
Ebola virus disease outbreak in Korea: use of a mathematical model and stochastic simulation to estimate risk [PDF]
Epidemiology and Health, 2019 OBJECTIVES According to the World Health Organization, there have been frequent reports of Ebola virus disease (EVD) since the 2014 EVD pandemic in West Africa. We aim to estimate the outbreak scale when an EVD infected person arrives in Korea.
Youngsuk Ko +4 more
doaj +1 more source
Frontiers in Immunology, 2021 Three clinically relevant ebolaviruses – Ebola (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) viruses, are responsible for severe disease and occasional deadly outbreaks in Africa.
Pavlo Gilchuk +24 more
doaj +1 more source
Estimating the reproduction number of Ebola virus (EBOV) during the 2014 outbreak in West Africa [PDF]
, 2014 The 2014 Ebola virus (EBOV) outbreak in West Africa is the largest outbreak of the genus Ebolavirus to date. To better understand the spread of infection in the affected countries, it is crucial to know the number of secondary cases generated by an ...
Althaus, Christian L.
core +2 more sources
Plant phenology supports the multi-emergence hypothesis for ebola spillover events [PDF]
, 2017 Ebola virus disease outbreaks in animals (including humans and great apes) start with sporadic host switches from unknown reservoir species. The factors leading to such spillover events are little explored.
Douglas, Noah E. +6 more
core +1 more source
Oral administration of obeldesivir protects nonhuman primates against Sudan ebolavirus
ScienceObeldesivir (ODV, GS-5245) is an orally administered prodrug of the parent nucleoside of remdesivir (RDV) and is presently in phase 3 trials for COVID-19 treatment.
R. Cross +21 more
semanticscholar +1 more source
Ecological indicators of mammal exposure to Ebolavirus [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2019 Much of the basic ecology of Ebolavirus remains unresolved despite accumulating disease outbreaks, viral strains and evidence of animal hosts. Because human Ebolavirus epidemics have been linked to contact with wild mammals other than bats, traits shared by species that have been infected by Ebolavirus and their phylogenetic distribution could suggest ...
John Paul Schmidt +5 more
openaire +4 more sources
Ebolavirus Classification Based on Natural Vectors [PDF]
DNA and Cell Biology, 2015 According to the WHO, ebolaviruses have resulted in 8818 human deaths in West Africa as of January 2015. To better understand the evolutionary relationship of the ebolaviruses and infer virulence from the relationship, we applied the alignment-free natural vector method to classify the newest ebolaviruses.
Hui Zheng +5 more
openaire +3 more sources
Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The membrane fusion proteins of viral pathogens as diverse in their replication strategies as coronaviruses and filoviruses depend, for their functional activity, on proteolytic processing during cell entry.
Yuan-Lin Kang +10 more
semanticscholar +2 more sources