Results 11 to 20 of about 25,220 (171)
Therapeutic vaccination strategies against EBOV by rVSV-EBOV-GP: the role of innate immunity
Current Opinion in Virology, 2021 Zaire Ebola virus (EBOV) is a member of the Filoviridae family. Infection with EBOV causes Ebola virus disease (EVD) characterized by excessive inflammation, lymphocyte death, coagulopathy, and multi-organ failure. In 2019, the FDA-approved the first anti-EBOV vaccine, rVSV-EBOV-GP (Ervebo® by Merck).
Amanda N Pinski, Ilhem Messaoudi
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Ebola Virus (EBOV) VP24 Inhibits Transcription and Replication of the EBOV Genome [PDF]
The Journal of Infectious Diseases, 2007 The roles of Ebola virus (EBOV) VP24 in nucleocapsid (NC) formation and the effect of VP24 on transcription and replication of the viral genome during NC formation remain unknown. We therefore examined the effect of VP24 on the expression of a reporter gene (luciferase), viral RNA, and messenger RNA from the EBOV minigenome.
Shinji, Watanabe +4 more
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Small Molecule Inhibition of Mononegavirales RNA Polymerases. [PDF]
J Med VirolABSTRACT The order Mononegavirales includes several non‐segmented negative‐sense RNA viruses that are significant human pathogens, whose transcription and replication depend on multifunctional RNA‐dependent RNA polymerase (L protein). Recent discoveries in cryo‐electron microscopy (cryo‐EM) have elucidated the structures of these polymerases and their ...
Cao CR, Mohammed M, Yang G, Wang D.
europepmc +2 more sources
The Utility of Human Immune System Mice for High-Containment Viral Hemorrhagic Fever Research
Vaccines, 2020 Human immune system (HIS) mice are a subset of humanized mice that are generated by xenoengraftment of human immune cells or tissues and/or their progenitors into immunodeficient mice.
David M. Wozniak +3 more
doaj +1 more source
Ebola Virus IgG Seroprevalence in Southern Mali
Emerging Infectious Diseases, 2021 Mali had 2 reported introductions of Ebola virus (EBOV) during the 2013–2016 West Africa epidemic. Previously, no evidence for EBOV circulation was reported in Mali. We performed an EBOV serosurvey study in southern Mali.
Sidy Bane +8 more
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Phylogenetic Analysis of Guinea 2014 EBOV Ebolavirus Outbreak [PDF]
PLoS Currents, 2014 Members of the genus Ebolavirus have caused outbreaks of haemorrhagic fever in humans in Africa. The most recent outbreak in Guinea, which began in February of 2014, is still ongoing. Recently published analyses of sequences from this outbreak suggest that the outbreak in Guinea is caused by a divergent lineage of Zaire ebolavirus.
Gytis Dudas, Andrew Rambaut
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Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. [PDF]
PLoS ONE, 2013 Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic compartment, where viral fusion occurs, providing a ...
Charles J Shoemaker +7 more
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The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection
iScience, 2021 Summary: Ebola virus (EBOV) is responsible for outbreaks with case fatality rates of up to 90% and for an epidemic in West Africa with more than ten thousand deaths.
Gergely Imre +11 more
doaj +1 more source
Journal of Innate Immunity, 2021 Expression of the extensively glycosylated Ebolavirus glycoprotein (EBOV-GP) induces physical alterations of surface molecules and plays a crucial role in viral pathogenicity.
Mostafa Jarahian +11 more
doaj +1 more source
npj Vaccines, 2023 Ebola virus (EBOV) and related filoviruses such as Sudan virus (SUDV) threaten global public health. Effective filovirus vaccines are available only for EBOV, yet restricted to emergency use considering a high reactogenicity and demanding logistics. Here
Viktor Lemmens +9 more
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