Results 11 to 20 of about 28,261 (176)

Transcriptomic analysis reveals a previously unknown role for CD8+ T-cells in rVSV-EBOV mediated protection

Scientific Reports, 2017
Ebola virus (EBOV) poses a significant threat to human health as highlighted by the recent epidemic in West Africa. Data from animal studies and a ring vaccination clinical trial conducted in Guinea during the recent epidemic demonstrated that a ...
Andrea R. Menicucci, Suhas Sureshchandra, Andrea Marzi, Heinz Feldmann, Ilhem Messaoudi   +4 more
doaj   +2 more sources

EBOV-infected cells and virions.

, 2022
Huh7 cells were infected with EBOV at an MOI of 5 and fixed at 2 dpi. (A) Thin section of EBOV-infected cell releasing viral particles. (B) Thin section shows virus budding; inset shown on the right is magnified 3x; protein is black.
Andrew A. Wilson (380681), Esther Bullitt (29343), Andrew Emili (65325), Adam J. Hume (6107039), Jessie Huang (8173488), Maria Ericsson (248579), Judith Olejnik (367849), Darrell N. Kotton (12047466), Tran T. N. Thao (12047451), Ryan M. Hekman (12047454), Ellen L. Suder (11052948), Jacquelyn Turcinovic (12047448), Mitchell R. White (591804), Daniel Cifuentes (251834), Ferenc Jakab (390063), Baylee Heiden (12047442), Whitney A. Scoon (12047445), Konstantinos-Dionysios Alysandratos (12047460), Joseph E. Kaserman (12047457), Gabor Kemenesi (12047469), Stephen Ross (4864357), Volker Thiel (78076), Gabor E. Toth (12047463), John H. Connor (406960), Elke Mühlberger (45516)   +24 more
core   +2 more sources

The Utility of Human Immune System Mice for High-Containment Viral Hemorrhagic Fever Research

Vaccines, 2020
Human immune system (HIS) mice are a subset of humanized mice that are generated by xenoengraftment of human immune cells or tissues and/or their progenitors into immunodeficient mice.
David M. Wozniak, Kerry J. Lavender, Joseph Prescott, Jessica R. Spengler   +3 more
doaj   +1 more source

The sphingosine kinase 1 activator, K6PC-5, attenuates Ebola virus infection

iScience, 2021
Summary: Ebola virus (EBOV) is responsible for outbreaks with case fatality rates of up to 90% and for an epidemic in West Africa with more than ten thousand deaths.
Gergely Imre, Verena Krähling, Madeleine Eichler, Sandra Trautmann, Nerea Ferreirós, M. Javad Aman, Fatah Kashanchi, Krishnaraj Rajalingam, Stefan Pöhlmann, Stephan Becker, Dagmar Meyer zu Heringdorf, Josef Pfeilschifter   +11 more
doaj   +1 more source

This table presents the amount of GP-EBOV-m, GP-EBOV-kis, NP-EBOV-m, and VP-EBOV-m antibody titers measured using LUMINEX assay.

, 2023
This table presents the amount of GP-EBOV-m, GP-EBOV-kis, NP-EBOV-m, and VP-EBOV-m antibody titers measured using LUMINEX assay.
Ynke Larivière (16920398), Emmanuel Esanga (16920410), Hypolite Muhindo-Mavoko (16920416), Trésor Zola Matuvanga (16920395), Vivi Maketa (361955), Bernard Isekah Osang’ir (16920401), Pierre Van Damme (147759), Jean-Pierre Van Geertruyden (3525035), Jean-Jacques Muyembe Tamfum (11285914), Rachel Meta (16920407), Steve Ahuka Mundeke (16920413), Joachim Mariën (3968132), Solange Milolo (16920404), Patrick Mitashi (116126), Junior Matangila (650176)   +14 more
core   +1 more source

Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. [PDF]

PLoS ONE, 2013
Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans and non-human primates. Infection requires internalization from the cell surface and trafficking to a late endocytic compartment, where viral fusion occurs, providing a ...
Charles J Shoemaker, Kathryn L Schornberg, Sue E Delos, Corinne Scully, Hassan Pajouhesh, Gene G Olinger, Lisa M Johansen, Judith M White   +7 more
doaj   +1 more source

Activating Natural Killer Cell Receptors, Selectins, and Inhibitory Siglecs Recognize Ebolavirus Glycoprotein

Journal of Innate Immunity, 2021
Expression of the extensively glycosylated Ebolavirus glycoprotein (EBOV-GP) induces physical alterations of surface molecules and plays a crucial role in viral pathogenicity.
Mostafa Jarahian, Katharina Marstaller, Nadine Banna, Roshanak Ahani, Mohammad Hossein Etemadzadeh, Lea K. Boller, Kayhan Azadmanesh, Angel Cid-Arregui, Abdolrahman Khezri, Martin R. Berger, Frank Momburg, Carsten Watzl   +11 more
doaj   +1 more source

Systemic and Mucosal Immune Responses From Serotype-Switched Viral-Vectored Ebola Vaccines. [PDF]

J Med Virol
ABSTRACT Ebola virus is a highly virulent pathogen causing severe hemorrhagic fever with 25%–90% mortality. The 2014 outbreak infected over 28,000 people, causing 11,325 deaths. Although there is one FDA‐approved vaccine available for limited use, additional vaccines are needed.
Wiggins J, Madapong A, Weaver E.
europepmc   +2 more sources

This table presents the amount of GP-EBOV-k antibody titers measured using FANG ELISA assay.

, 2023
This table presents the amount of GP-EBOV-k antibody titers measured using FANG ELISA assay.
Ynke Larivière (16920398), Emmanuel Esanga (16920410), Hypolite Muhindo-Mavoko (16920416), Trésor Zola Matuvanga (16920395), Vivi Maketa (361955), Bernard Isekah Osang’ir (16920401), Pierre Van Damme (147759), Jean-Pierre Van Geertruyden (3525035), Jean-Jacques Muyembe Tamfum (11285914), Rachel Meta (16920407), Steve Ahuka Mundeke (16920413), Joachim Mariën (3968132), Solange Milolo (16920404), Patrick Mitashi (116126), Junior Matangila (650176)   +14 more
core   +1 more source

YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge

npj Vaccines, 2023
Ebola virus (EBOV) and related filoviruses such as Sudan virus (SUDV) threaten global public health. Effective filovirus vaccines are available only for EBOV, yet restricted to emergency use considering a high reactogenicity and demanding logistics. Here
Viktor Lemmens, Lara Kelchtermans, Sarah Debaveye, Winston Chiu, Thomas Vercruysse, Ji Ma, Hendrik Jan Thibaut, Johan Neyts, Lorena Sanchez-Felipe, Kai Dallmeier   +9 more
doaj   +1 more source