Results 41 to 50 of about 28,261 (176)

Single-dose treatment with VSV-EBOV expressing Ebola virus-specific artificial miRNAs does not protect mice from lethal disease

, 2023
Although significant progress has been made in the development of therapeutics against Ebola virus (EBOV), we sought to expand upon existing strategies and combine an RNAi-based intervention with the approved VSV-EBOV vaccine to conjointly treat and ...
Feldmann, Heinz, Julie Callison, Kyle L O’Donnell, Andrea Marzi, O’Donnell, Kyle L, Thomas Hoenen, Heinz Feldmann, Callison, Julie, Hoenen, Thomas, Marzi, Andrea   +9 more
core   +1 more source

Acute malaria dysregulates specialized lymph node macrophages to suppress vaccine-elicited protection against the Ebola virus

mBio
The filovirus, Ebola virus (EBOV), causes outbreaks of EBOV disease (EVD) throughout equatorial Africa. ERVEBO is a replication-competent recombinant vesicular stomatitis virus-vectored vaccine encoding the EBOV glycoprotein (recombinant vesicular ...
Jonah Elliff, Lindsey Grady, Kyle L. O'Donnell, Caitlin Messingham, Kai J. Rogers, Jobaida Akther, Andrew Thurman, Rahul Vijay, Alejandro Pezzulo, Troy Randall, Andrea Marzi, Noah S. Butler, Wendy Maury   +12 more
doaj   +1 more source

Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia

Emerging Infectious Diseases, 2015
To support Liberia’s response to the ongoing Ebola virus (EBOV) disease epidemic in Western Africa, we established in-country advanced genomic capabilities to monitor EBOV evolution.
Jeffrey R. Kugelman, Michael R. Wiley, Suzanne Mate, Jason T. Ladner, Brett Beitzel, Lawrence Fakoli, Fahn Taweh, Karla Prieto, Joseph W. Diclaro, Timothy Minogue, Randal J. Schoepp, Kurt E. Schaecher, James Pettitt, Stacey Bateman, Joseph Fair, Jens H. Kuhn, Lisa Hensley, Daniel J. Park, Pardis C. Sabeti, Mariano Sanchez-Lockhart, Fatorma K. Bolay, Gustavo Palacios   +21 more
doaj   +1 more source

Human Antibody Repertoire following Ebola Virus Infection and Vaccination

iScience, 2020
Summary: Limited knowledge exists on the quality of polyclonal antibody response generated following Ebola virus (EBOV) infection compared with vaccination.
Sandra Fuentes, Supriya Ravichandran, Elizabeth M. Coyle, Laura Klenow, Surender Khurana   +4 more
doaj   +1 more source

Identification and Optimization of a Truncated Hs‐1‐Derived Antimicrobial Peptide for Enhanced Broad‐Spectrum Antiviral Activity

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Can a shorter peptide be a better antiviral? Structure‐guided optimization of the amphibian peptide Hs‐1 reveals a minimal α‐helical core that, after terminal modification, displays enhanced stability and submicromolar broad‐spectrum activity against enveloped viruses while maintaining a favorable safety profile. Antimicrobial peptides (AMPs) represent
Carla Zannella, Annalisa Chianese, Rosa Giugliano, Roberta Della Marca, Alessandra Monti, Martina Dragone, Gaetano Malgieri, Nunzianna Doti, Carla Isernia, Anna De Filippis, Massimiliano Galdiero   +10 more
wiley   +1 more source

Detection of EBOV antibodies, Lagos, Nigeria.

, 2018
(A) Sera samples from 3 EVD survivors, 10 documented EVD contacts, and 6 control HCWs were subjected to LFn-EBOV-GP1 and LFn-EBOV-sGP Western blot analysis. +, positive control. Molecular size marker units are kDa. EVD, Ebola virus disease. Control HCWs,
Onikepe Folarin (305194), Bobby Brooke Herrera (814469), Christian T. Happi (305230), Philomena Eromon (5278073), Yichen Lu (111597), Rolake Akinsola (5278064), Donald J. Hamel (5278079), Folasade Ogunsola (269175), Phyllis J. Kanki (459676), Philip Oshun (5278070), Charlotte A. Chang (3232419), Kayode T. Adeyemi (5278076), Alani S. Akanmu (5278067)   +12 more
core   +1 more source

An mRNA vaccine encoding the Ebola virus glycoprotein induces high neutralizing antibody titers and provides strong protection against lethal infections in mouse models

Frontiers in Immunology
Ebola virus (EBOV) is the causative agent of Ebola disease (EBOD), a viral hemorrhagic fever with a notably high case fatality rate. Current treatments for EBOD are limited to monoclonal antibodies or two licensed viral vector vaccines, a recombinant ...
Zachary R. Stromberg, Elvia E. Silva, Sara C. Johnston, Dylan M. Johnson, Dominique Hall, Emmanuel F. Adjei, Emmanuel F. Adjei, John A. Altin, Abisola Abisoye-Ogunniyan, Travis Gollott, Wei He, Iris K. A. Jones, Steve Kwilas, Sean J. Lund, Heather L. Mead, Georgia A. Nelson, Lisa Ouyang, Sandra K. G. Peters, Jennifer L. Schwedler, Caleb Z. Trecazzi, Matthew W. Turner, Chunyan Ye, Steven B. Bradfute, Nicholas O. Fischer, Jay W. Hooper, Jason T. Ladner, Jason T. Ladner, Amy Rasley, Amy Rasley, Oscar A. Negrete   +29 more
doaj   +1 more source

Ebola virus persistence: implications for human-to-human transmission and new outbreaks [PDF]

Exploration of Medicine
Ebola virus (EBOV) infection usually leads to highly lethal EBOV disease (EVD) with associated viraemia. Viraemia is cleared in those that do survive, however, EBOV may remain hidden in the testes and other immune privileged niches (IPNs) where it can ...
Oliver Meek, Kimberly Fornace, Miles W. Carroll   +2 more
doaj   +1 more source

Contrasting effects of filamin A and B proteins in modulating filovirus entry.

PLoS Pathogens, 2023
Ebola (EBOV) and Marburg viruses (MARV) cause severe hemorrhagic fever associated with high mortality rates in humans. A better understanding of filovirus-host interactions that regulate the EBOV and MARV lifecycles can provide biological and mechanistic
Ariel Shepley-McTaggart, Jingjing Liang, Yang Ding, Marija A Djurkovic, Valeriia Kriachun, Olena Shtanko, Oriol Sunyer, Ronald N Harty   +7 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, Volume 13, Issue 39, 13 July 2026.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source