Results 41 to 50 of about 25,220 (171)

Ebolavirus is evolving but not changing: No evidence for functional change in EBOV from 1976 to the 2014 outbreak [PDF]

Virology, 2015
The 2014 epidemic of Ebola virus disease (EVD) has had a devastating impact in West Africa. Sequencing of ebolavirus (EBOV) from infected individuals has revealed extensive genetic variation, leading to speculation that the virus may be adapting to humans, accounting for the scale of the 2014 outbreak.
Olabode, Abayomi S., Jiang, Xiaowei, Robertson, David L., Lovell, Simon C.   +3 more
openaire   +3 more sources

Ebola virus persistence: implications for human-to-human transmission and new outbreaks [PDF]

Exploration of Medicine
Ebola virus (EBOV) infection usually leads to highly lethal EBOV disease (EVD) with associated viraemia. Viraemia is cleared in those that do survive, however, EBOV may remain hidden in the testes and other immune privileged niches (IPNs) where it can ...
Oliver Meek, Kimberly Fornace, Miles W. Carroll   +2 more
doaj   +1 more source

Identification and Optimization of a Truncated Hs‐1‐Derived Antimicrobial Peptide for Enhanced Broad‐Spectrum Antiviral Activity

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Can a shorter peptide be a better antiviral? Structure‐guided optimization of the amphibian peptide Hs‐1 reveals a minimal α‐helical core that, after terminal modification, displays enhanced stability and submicromolar broad‐spectrum activity against enveloped viruses while maintaining a favorable safety profile. Antimicrobial peptides (AMPs) represent
Carla Zannella, Annalisa Chianese, Rosa Giugliano, Roberta Della Marca, Alessandra Monti, Martina Dragone, Gaetano Malgieri, Nunzianna Doti, Carla Isernia, Anna De Filippis, Massimiliano Galdiero   +10 more
wiley   +1 more source

Antibody quality and protection from lethal Ebola virus challenge in nonhuman primates immunized with rabies virus based bivalent vaccine.

PLoS Pathogens, 2013
We have previously described the generation of a novel Ebola virus (EBOV) vaccine platform based on (a) replication-competent rabies virus (RABV), (b) replication-deficient RABV, or (c) chemically inactivated RABV expressing EBOV glycoprotein (GP). Mouse
Joseph E Blaney, Andrea Marzi, Mallory Willet, Amy B Papaneri, Christoph Wirblich, Friederike Feldmann, Michael Holbrook, Peter Jahrling, Heinz Feldmann, Matthias J Schnell   +9 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, Volume 13, Issue 39, 13 July 2026.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Clock Rooting Further Demonstrates that Guinea 2014 EBOV is a Member of the Zaïre Lineage

PLoS Currents, 2014
While initial phylogenetic analyses concluded to Guinea 2014 EBOV falling outside the Zaïre lineage (ZEBOV), a recent re-analysis of the same dataset by Dudas and Rambaut (2014) suggested that Guinea 2014 EBOV actually is ZEBOV. Under the same hypothesis as used by these authors (the molecular clock hypothesis), we reinforce their conclusion by ...
Calvignac-Spencer, Sébastien, Schulze, Jakob M., Zickmann, Franziska, Renard, Bernhard Y.   +3 more
openaire   +2 more sources

Sequence optimized diagnostic assay for Ebola virus detection

Scientific Reports, 2023
Rapid pathogen identification is a critical first step in patient isolation, treatment, and controlling an outbreak. Real-time PCR is a highly sensitive and specific approach commonly used for infectious disease diagnostics.
Jeffrey W. Koehler, Christopher P. Stefan, Adrienne T. Hall, Korey L. Delp, Aileen E. O’Hearn, Cheryl L. Taylor-Howell, Nadia Wauquier, Randal J. Schoepp, Timothy D. Minogue   +8 more
doaj   +1 more source

Complement-Mediated Neutralisation Identified in Ebola Virus Disease Survivor Plasma: Implications for Protection and Pathogenesis

Frontiers in Immunology, 2022
The 2013–2016 Ebola virus (EBOV) epidemic in West Africa was unprecedented in case numbers and fatalities, and sporadic outbreaks continue to arise.
Jack Mellors, Jack Mellors, Jack Mellors, Tom Tipton, Sarah Katharina Fehling, Joseph Akoi Bore, Joseph Akoi Bore, Fara Raymond Koundouno, Fara Raymond Koundouno, Yper Hall, Jacob Hudson, Jacob Hudson, Jacob Hudson, Frances Alexander, Stephanie Longet, Stephen Taylor, Andrew Gorringe, N’Faly Magassouba, Mandy Kader Konde, Julian Hiscox, Thomas Strecker, Miles Carroll   +21 more
doaj   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Human Antibody Repertoire following Ebola Virus Infection and Vaccination

iScience, 2020
Summary: Limited knowledge exists on the quality of polyclonal antibody response generated following Ebola virus (EBOV) infection compared with vaccination.
Sandra Fuentes, Supriya Ravichandran, Elizabeth M. Coyle, Laura Klenow, Surender Khurana   +4 more
doaj   +1 more source