Results 61 to 70 of about 25,220 (171)

Bioinformatics Study on Zaire Ebolavirus (EBOV) Protein for Better Understanding the Vaccine Development

International Journal of Applied Sciences and Biotechnology, 2014
Nine, Ebola viruse EBOV (Zaire ebolavirus), proteins are extracted from the NCBI repository and their study was carried out. The physicchemical properties and evolutionary link with other such viruses by homology modeling were carried out. All the proteins show rich in leucine domain an ideal requirement for fast attachment of the virus to the receptor
Ashokan Kannarath, D.Y. Mundaganur, D.S. Mundaganur   +2 more
openaire   +2 more sources

Cohorts of immature Pteropus bats show interannual variation in Hendra virus serology

Journal of Animal Ecology, Volume 95, Issue 3, Page 521-537, March 2026.
Pteropus bat with offspring, photo taken by Manuel Ruiz‐Aravena. Abstract Understanding the drivers of seasonal disease outbreaks remains a fundamental challenge in disease ecology. Periodic outbreaks can be driven by several seasonally varying factors, including pulses of susceptible individuals through births, changes in host behaviour and social ...
Daniel E. Crowley, Caylee A. Falvo, Chris K. Grant, Benny Borremans, Tamika J. Lunn, Manuel Ruiz‐Aravena, Evelyn Benson, Clifton D. McKee, Daniel J. Becker, Devin N. Jones, Trenton Bushmaker, Y. Tina Yu, Michelle Michie, Adrienne S. Dale, Lianying Yan, Spencer L. Sterling, Christopher C. Broder, Laura B. Goodman, Rasa Petraityte‐Burneikiene, Eric D. Laing, Ina L. Smith, Vincent J. Munster, Agnieszka Rynda‐Apple, Alison J. Peel, Raina Plowright   +24 more
wiley   +1 more source

Low seroprevalence of Ebola virus in health care providers in an endemic region (Tshuapa province) of the Democratic Republic of the Congo

PLoS ONE, 2023
Introduction A serosurvey among health care providers (HCPs) and frontliners of an area previously affected by Ebola virus disease (EVD) in the Democratic Republic of the Congo (DRC) was conducted to assess the seroreactivity to Ebola virus antigens ...
Trésor Zola Matuvanga, Joachim Mariën, Ynke Larivière, Bernard Isekah Osang’ir, Solange Milolo, Rachel Meta, Emmanuel Esanga, Vivi Maketa, Junior Matangila, Patrick Mitashi, Steve Ahuka Mundeke, Hypolite Muhindo-Mavoko, Jean-Jacques Muyembe Tamfum, Pierre Van Damme, Jean-Pierre Van Geertruyden   +14 more
doaj  

Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia

Emerging Infectious Diseases, 2015
To support Liberia’s response to the ongoing Ebola virus (EBOV) disease epidemic in Western Africa, we established in-country advanced genomic capabilities to monitor EBOV evolution.
Jeffrey R. Kugelman, Michael R. Wiley, Suzanne Mate, Jason T. Ladner, Brett Beitzel, Lawrence Fakoli, Fahn Taweh, Karla Prieto, Joseph W. Diclaro, Timothy Minogue, Randal J. Schoepp, Kurt E. Schaecher, James Pettitt, Stacey Bateman, Joseph Fair, Jens H. Kuhn, Lisa Hensley, Daniel J. Park, Pardis C. Sabeti, Mariano Sanchez-Lockhart, Fatorma K. Bolay, Gustavo Palacios   +21 more
doaj   +1 more source

Risk Factors Associated with Ebola and Marburg Viruses Seroprevalence in Blood Donors in the Republic of Congo. [PDF]

PLoS Neglected Tropical Diseases, 2015
BACKGROUND:Ebola and Marburg viruses (family Filoviridae, genera Ebolavirus and Marburgvirus) cause haemorrhagic fevers in humans, often associated with high mortality rates.
Nanikaly Moyen, Laurence Thirion, Petra Emmerich, Amelia Dzia-Lepfoundzou, Hervé Richet, Yannik Boehmann, Yannick Dimi, Pierre Gallian, Ernest A Gould, Stephan Günther, Xavier de Lamballerie   +10 more
doaj   +1 more source

Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe, Tamara Zoran, Marylyn Martina Addo   +2 more
wiley   +1 more source

Ebola virus disrupts the inner blood-retinal barrier by induction of vascular endothelial growth factor in pericytes

PLoS Pathogens, 2023
Ebola virus (EBOV) causes severe hemorrhagic fever in humans with high mortality. In Ebola virus disease (EVD) survivors, EBOV persistence in the eyes may break through the inner blood–retinal barrier (iBRB), leading to ocular complications and EVD ...
Jiawang Gao, Zhengyuan Guo, Wei Li, Xiaowei Zhang, Xian-En Zhang, Zongqiang Cui   +5 more
doaj  

Monodentate Phosphine Modulation in Cyclometallated Platinum(II) Complexes for Antileishmanial, Antiviral, and Antitumor Applications

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Schematic representation depicting the influence of phosphine ligand identity on the biological and physicochemical characteristics of Pt(II) complexes: PTA promotes antileishmanial activity, PPh2(Php–COOH) strengthens antiviral activity, and TCEP enhances fluorescence.
Antonio A. de Oliveira‐Neto, Gustavo Clauss, Jennyfer Castro, Marcus S. A. Garcia, Natasha M. Cassani, Bruna C. Sandim, Ana Laura C. Oliveira, Stephanie P. B. Reyes, Nádija N. P. da Silva, Fillipe V. Rocha, Ana C. G. Jardim, Danilo C. Miguel, Camilla Abbehausen   +12 more
wiley   +1 more source

Host Adaptation and Evolutionary Analysis of Zaire ebolavirus: Insights From Codon Usage Based Investigations

Frontiers in Microbiology, 2020
Ebola virus (EBOV) has caused several outbreaks as the consequence of spillover events from zoonotic sources and has resulted in huge death tolls. In spite of considerable progress, a thorough know-how regarding EBOV adaptation in various host species ...
Wen Luo, Wen Luo, Ayan Roy, Fucheng Guo, David M. Irwin, David M. Irwin, Xuejuan Shen, Junbin Pan, Yongyi Shen, Yongyi Shen, Yongyi Shen   +10 more
doaj   +1 more source

Direct‐to‐Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery

ChemMedChem, Volume 21, Issue 4, 25 February 2026.
Crude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Ariane F. Hübner, Fabian Barthels
wiley   +1 more source