Results 51 to 60 of about 25,220 (171)

One Yeast, Sixteen Synthetic Chromosomes, Infinite Possibilities

Yeast, Volume 43, Issue 4, Page 143-158, July 2026.
ABSTRACT The evolution of the yeast, Saccharomyces cerevisiae, from a genetically tractable model organism to a chassis for genome‐scale engineering represents one of the most influential trajectories in eukaryotic biology. The Synthetic Yeast Genome Project (Sc2.0) embodies the current height of this trajectory, having now delivered functional ...
Edward Archer, Roy S. K. Walker, Paige E. Erpf, Ian T. Paulsen, Isak S. Pretorius   +4 more
wiley   +1 more source

Advancing Antiviral Design: Integrating Natural Products, Computation and Targeted Delivery

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
A stepwise translational framework linking natural‐product discovery, computational prioritisation, experimental validation, lead optimisation and targeted delivery is proposed to advance antiviral design. ABSTRACT The COVID‐19 pandemic highlighted the role of rapid viral mutation and global connectivity in accelerating viral emergence and spread ...
Adedayo Ayodeji Lanrewaju, Abimbola Motunrayo Folami, Saheed Sabiu, Feroz Mahomed Swalaha   +3 more
wiley   +1 more source

Contrasting effects of filamin A and B proteins in modulating filovirus entry.

PLoS Pathogens, 2023
Ebola (EBOV) and Marburg viruses (MARV) cause severe hemorrhagic fever associated with high mortality rates in humans. A better understanding of filovirus-host interactions that regulate the EBOV and MARV lifecycles can provide biological and mechanistic
Ariel Shepley-McTaggart, Jingjing Liang, Yang Ding, Marija A Djurkovic, Valeriia Kriachun, Olena Shtanko, Oriol Sunyer, Ronald N Harty   +7 more
doaj   +1 more source

Ebola virus outbreak preparedness plan for developing Nations: Lessons learnt from affected countries

Journal of Infection and Public Health, 2021
Background: Ebola virus (EBOV); a public health emergency of international concern,is known to pose threat of global outbreaks. EBOV has spread in African continent and due to unchecked international travel, importation of cases has been reported in ...
Swati Gupta, Nivedita Gupta, Pragya Yadav, Deepak Patil   +3 more
doaj   +1 more source

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

Development of an EBOV MiniG plus system as an advanced tool for anti-Ebola virus drug screening

Heliyon, 2023
The incidence of zoonotic diseases, such as coronavirus disease 2019 and Ebola virus disease, is increasing worldwide. However, drug and vaccine development for zoonotic diseases has been hampered because the experiments involving live viruses are limited to high-containment laboratories.
Chi-Ju Hsu, Cheng-Hsiu Chen, Wen-Ting Chen, Ping-Cheng Liu, Tein-Yao Chang, Meng-He Lin, Cheng-Cheung Chen, Hsing-Yu Chen, Chih-Heng Huang, Yun-Hsiang Cheng, Jun-Ren Sun   +10 more
openaire   +3 more sources

Ebola virus-induced eye sequelae: a murine model for evaluating glycoprotein-targeting therapeuticsResearch in context

EBioMedicine
Summary: Background: Ebola virus disease (EVD) survivors experience ocular sequelae including retinal lesions, cataracts, and vision loss. While monoclonal antibodies targeting the Ebola virus glycoprotein (EBOV-GP) have shown promise in improving ...
Ha-Na Lee, Biying Xu, Aaron P. Lewkowicz, Kaliroi Engel, Logan Kelley-Baker, Ian L. McWilliams, Derek D.C. Ireland, Jennifer L. Kielczewski, Jinbo Li, Robert N. Fariss, Mercedes M. Campos, Alina Baum, Christos Kyratsous, Kristen Pascal, Chi-Chao Chan, Rachel R. Caspi, Mohanraj Manangeeswaran, Daniela Verthelyi   +17 more
doaj   +1 more source

Generation and Characterization of a Mouse-Adapted Makona Variant of Ebola Virus

Viruses, 2019
Ebola virus (EBOV) is a zoonotic pathogen that poses a significant threat to public health, causing sporadic yet devastating outbreaks that have the potential to spread worldwide, as demonstrated during the 2013−2016 West African outbreak.
Mable Chan, Anders Leung, Bryan D. Griffin, Robert Vendramelli, Nikesh Tailor, Kevin Tierney, Jonathan Audet, Darwyn Kobasa   +7 more
doaj   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Inhibition of PIKfyve kinase prevents infection by EBOV and SARS-CoV-2

, 2020
Virus entry is a multistep process. It initiates when the virus attaches to the host cell and ends when the viral contents reach the cytosol. Genetically unrelated viruses can subvert analogous subcellular mechanisms and use similar trafficking pathways for successful entry.
Kang, Yuan-Lin, Chou, Yi-Ying, Rothlauf, Paul W., Liu, Zhuoming, Soh, Timothy K., Cureton, David, Case, James Brett, Chen, Rita E., Diamond, Michael S., Whelan, Sean P. J., Kirchhausen, Tom   +10 more
openaire   +1 more source