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Biological Activities and Clinical Potential of Ebselen
1990Ebselen (2-pheny1–1,2-benzisoselenazol-3(2H)-one; Fig. 1) is a seleno-organic compound which exhibits catalytic GSH-dependent, hydroperoxide reducing properties, similar to the action of glutathione peroxidase (GSH-Px)1–3.
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Modeling the Mechanism of the Glutathione Peroxidase Mimic Ebselen
Inorganic Chemistry, 2011Ebselen (1), the quintessential mimic of the antioxidant selenoenzyme glutathione peroxidase (GPx), is a potential chemopreventative for various diseases associated with oxidative stress. Density-functional theory (DFT) and solvent-assisted proton exchange (SAPE) are used to model the complex mechanism for scavenging of reactive oxygen species by 1 ...
Sonia, Antony, Craig A, Bayse
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Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite
1996Publisher Summary The compound ebselen is considered capable of contributing to the antioxidant defense in tissues. Many of the biological properties of ebselen were explainable on the basis of its property as an enzyme mimic, carrying out the function of the selenoenzyme, GSH peroxidase (GPx), and of phospholipid hydroperoxide GSH peroxidase (PHGPx).
H, Sies, H, Masumoto
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Determination of Ebselen by HPLC: Validation and Application of the Method
Chromatographia, 2004Ebselen is an organo-selenium, highly hydrophobic compound that exhibits glutathion peroxidase-like activity. It is now in phase III trials in Japan for investigating its effect on ischemic stroke. We have developed an HPLC method for the determination of Ebselen at ambient temperature and applied it to a patented tablet formulation.
Yilmaz, S, Yalcin, G
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Scavenging of hypochlorous acid by carvedilol and ebselen in vitro
General Pharmacology: The Vascular System, 19971. The antihypertensive drug carvedilol and the antiinflammatory selenoorganic compound ebselen were tested for their ability to react with the reactive oxygen species hypochlorous acid (HOCl) in vitro. 2. Carvedilol scavenges HOCl at a rate sufficient to protect a model molecule catalase against inactivation by HOCl. 3.
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Ebselen and Analogues: Pharmacological Properties and Synthetic Strategies for Their Preparation
Molecules, 2021Luca Sancineto, Claudio Santi
exaly