Results 141 to 150 of about 3,624 (175)

Modeling the Mechanism of the Glutathione Peroxidase Mimic Ebselen

Inorganic Chemistry, 2011
Ebselen (1), the quintessential mimic of the antioxidant selenoenzyme glutathione peroxidase (GPx), is a potential chemopreventative for various diseases associated with oxidative stress. Density-functional theory (DFT) and solvent-assisted proton exchange (SAPE) are used to model the complex mechanism for scavenging of reactive oxygen species by 1 ...
Sonia, Antony, Craig A, Bayse
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Biological Activities and Clinical Potential of Ebselen

1990
Ebselen (2-pheny1–1,2-benzisoselenazol-3(2H)-one; Fig. 1) is a seleno-organic compound which exhibits catalytic GSH-dependent, hydroperoxide reducing properties, similar to the action of glutathione peroxidase (GSH-Px)1–3.
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Metabolism and Disposition of Ebselen

1989
Ebselen [2-phenyl-1, 2-benzisoselenazol-3(2H)-one; PZ-51] represents a new class of anti-inflammatory agents as an example of seleno-organic compounds in the therapy of hydroperoxide-linked pathological conditions (see Parnham and Graf 1987 for review). Ebselen exhibits GSH peroxidase-like activity (Muller et al. 1984; Wendel et al.
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Binding of Ebselen to Plasma Protein

1989
Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) is a selenium-containing het-erocyclic compound, which exhibits GSH peroxidaselike activity in vitro and anti-inflammatory activity in vivo (Muller et al. 1984; Kuhl et al. 1985).
H. Nomura, H. Hakusui, T. Takegoshi
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Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite

1996
Publisher Summary The compound ebselen is considered capable of contributing to the antioxidant defense in tissues. Many of the biological properties of ebselen were explainable on the basis of its property as an enzyme mimic, carrying out the function of the selenoenzyme, GSH peroxidase (GPx), and of phospholipid hydroperoxide GSH peroxidase (PHGPx).
H, Sies, H, Masumoto
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Dual effect of ebselen on mitochondrial permeability transition

Biochemical Pharmacology, 2003
This study reports an investigation on the effect of the seleno-organic compound ebselen on rat liver mitochondria. We show that low concentrations of ebselen induced an increase in rat liver mitochondrial membrane permeability, resulting in swelling and loss of membrane potential.
Didier, Morin, Roland, Zini, Heidi, Ligeret, Wendi, Neckameyer, Serge, Labidalle, Jean Paul, Tillement   +5 more
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Action of ebselen as an antioxidant against lipid peroxidation

Biochemical Pharmacology, 1992
The action of ebselen (2-phenyl-1,2-benzoisoselenazol-3(2H)-one) as an antioxidant was studied under various conditions to clarify how it prevents oxidative damage. It did not react with diphenylpicrylhydrazyl nor did it suppress the oxidation of methyl linoleate in acetonitrile solution or in aqueous dispersions induced by free radical initiator ...
N, Noguchi, Y, Yoshida, H, Kaneda, Y, Yamamoto, E, Niki   +4 more
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Ebselen as a peroxynitrite scavenger in vitro and ex vivo

Biochemical Pharmacology, 2000
We have previously shown that peroxynitrite (PN) selectively impaired prostacyclin (PGI2)-dependent vasorelaxation by tyrosine nitration of PGI2 synthase in an in situ model (Zou MH, Jendral M and Ullrich V, Br J Pharmacol 126: 1283-1292, 1999). By using this established model, we tested whether or not ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one),
A, Daiber, M H, Zou, M, Bachschmid, V, Ullrich   +3 more
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Azaanalogues of Ebselen as Antimicrobial and Antiviral Agents: Synthesis and Properties.

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
H, Wójtowicz, K, Kloc, I, Maliszewska, J, Młochowski, M, Pietka, E, Piasecki   +5 more
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Scavenging of hypochlorous acid by carvedilol and ebselen in vitro

General Pharmacology: The Vascular System, 1997
1. The antihypertensive drug carvedilol and the antiinflammatory selenoorganic compound ebselen were tested for their ability to react with the reactive oxygen species hypochlorous acid (HOCl) in vitro. 2. Carvedilol scavenges HOCl at a rate sufficient to protect a model molecule catalase against inactivation by HOCl. 3.
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