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Ebselen attenuates tobramycin-induced ototoxicity in mice
Journal of Cystic Fibrosis, 2021Cystic fibrosis patients are often adminstered tobramycin to treat pulmonary infections. Unfortunately, a common side effect is hearing loss, which can fluctuate. Ebselen has known anti-inflammatory properties and could reduce the incidence and severity of tobramycin-induced hearing loss.In vitro: neonatal cochlear cultures were treated with tobramycin
Rende, Gu +3 more
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Molecular Pharmacology, 1990
The therapeutic effect of ebselen has been linked to its peroxidase activity. In the present study, the peroxidase activity of ebselen toward H2O2 with the endogenous thiols GSH and dihydrolipoate [L(SH)2] as cofactors was determined. When GSH was used, peroxide removal was described by a ter uni ping pong mechanism with Dalziel coefficients for GSH ...
Haenen, G R +3 more
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The therapeutic effect of ebselen has been linked to its peroxidase activity. In the present study, the peroxidase activity of ebselen toward H2O2 with the endogenous thiols GSH and dihydrolipoate [L(SH)2] as cofactors was determined. When GSH was used, peroxide removal was described by a ter uni ping pong mechanism with Dalziel coefficients for GSH ...
Haenen, G R +3 more
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Ebselen, a selenoorganic compound as glutathione peroxidase mimic
Free Radical Biology and Medicine, 1993The selenoorganic compound ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)-one, exhibits activity as an enzyme mimic. The reaction catalyzed is that of a glutathione (GSH) peroxidase (i.e., the reduction of a hydroperoxide at the expense of thiol). The specificity for substrates ranges from hydrogen peroxide and smaller organic hydroperoxides to membrane ...
Helmut Sies
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Ebselen, a Seleno-organic Antioxidant, as an Electrophile
Chemical Research in Toxicology, 2006Ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one], a seleno-organic compound showing glutathione peroxidase-like activity, is one of the promising synthetic antioxidants. In the present study, we investigated the electrophilic potential of this antioxidant and established the mechanism of the cysteine-targeted oxidation of protein.
Toyo, Sakurai +6 more
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Mechanisms of Ebselen as a Therapeutic and Its Pharmacology Applications
Future Medicinal Chemistry, 2020Ebselen is a synthetic organoselenium radical scavenger compound that possesses glutathione peroxidase-like activity and its own unique bioactivity by reacting with thiols, hydroperoxides and peroxynitrites. Owing to its high affinity toward several essential reactions, ebselen protects cellular components from oxidative and free radical damage, and it
Jun Wang +6 more
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Ebselen affects calcium homeostasis in human platelets
Biochemical Pharmacology, 1991Ebselen (PZ 51, 2-phenyl-1,2-benzoisoselenazol-3-(2H)-one) is a selenoorganic compound with anti-inflammatory properties. Its pharmacological action is thought to originate from its peroxidase activity which could lower the peroxide tonus required for cyclooxygenase and lipoxygenase activations.
B, Brüne, B, Diewald, V, Ullrich
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Metabolism and Disposition of Ebselen
1989Ebselen [2-phenyl-1, 2-benzisoselenazol-3(2H)-one; PZ-51] represents a new class of anti-inflammatory agents as an example of seleno-organic compounds in the therapy of hydroperoxide-linked pathological conditions (see Parnham and Graf 1987 for review). Ebselen exhibits GSH peroxidase-like activity (Muller et al. 1984; Wendel et al.
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Action of ebselen as an antioxidant against lipid peroxidation
Biochemical Pharmacology, 1992The action of ebselen (2-phenyl-1,2-benzoisoselenazol-3(2H)-one) as an antioxidant was studied under various conditions to clarify how it prevents oxidative damage. It did not react with diphenylpicrylhydrazyl nor did it suppress the oxidation of methyl linoleate in acetonitrile solution or in aqueous dispersions induced by free radical initiator ...
N, Noguchi +4 more
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Binding of Ebselen to Plasma Protein
1989Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) is a selenium-containing het-erocyclic compound, which exhibits GSH peroxidaselike activity in vitro and anti-inflammatory activity in vivo (Muller et al. 1984; Kuhl et al. 1985).
H. Nomura, H. Hakusui, T. Takegoshi
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The use of ebselen for radioprotection in cultured cells and mice
Free Radical Biology and Medicine, 2009Ionizing radiation induces the production of reactive oxygen species (ROS), which play an important causative role in cell death. Therefore, compounds that control the level of ROS may confer radioprotective effects. Ebselen, a seleno-organic compound, has been shown to protect against cell injury caused by ROS.
Jean Kyoung, Tak, Jeen-Woo, Park
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