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The Reaction of Ebselen with Peroxynitrite
Chemical Research in Toxicology, 1996Ebselen, 2-phenyl-1,2-benzisoselenazol-3(2H)-one, rapidly reacts with peroxynitrite, the rate constant being of the order of 10(6) M-1 s-1; the reaction yields the selenoxide of the parent molecule, 2-phenyl-1,2-benzisoselenazol-3(2H)-one 1-oxide, as the sole selenium-containing product; a stoichiometry of 1 mol of ebselen reacted and of the selenoxide
H, Masumoto, H, Sies
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Antimalarial properties of ebselen
Parasitology Research, 1989The seleno-organic compound ebselen showed anti-malarial activity in vitro against the murine Plasmodium berghei and the human P. falciparum. In P. berghei, the uptake and incorporation of [3H]-methionine and [3H]-adenosine was inhibited and the infectivity of plasmodia was reduced.
A M, Hüther +3 more
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Lipid peroxidation in presence of ebselen
Chemistry and Physics of Lipids, 1997Lipid peroxidation is initiated by cell damage. After homogenisation of porcine heart tissue in aqueous solution we observed the same lipid peroxidation products as detected after heart infarction. We used this observation to study the influence of ebselen (2-phenyl-1,2-benzoisoselenazol-3-(2H)-one) on the generation of oxidatively derived monohydroxy ...
A, Batna, C, Fuchs, G, Spiteller
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The Journal of Physical Chemistry A, 2007
Density functional theory calculations at the B3LYP/6-311++G(3df,3pd)//B3LYP/6-31G(d,p) level have been performed to elucidate the mechanism and reaction energetics for the reduction of hydrogen peroxide by ebselen, ebselen diselenide, ebselen selenol, and their sulfur analogues.
Jason K, Pearson, Russell J, Boyd
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Density functional theory calculations at the B3LYP/6-311++G(3df,3pd)//B3LYP/6-31G(d,p) level have been performed to elucidate the mechanism and reaction energetics for the reduction of hydrogen peroxide by ebselen, ebselen diselenide, ebselen selenol, and their sulfur analogues.
Jason K, Pearson, Russell J, Boyd
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The early research and development of ebselen
Biochemical Pharmacology, 2013Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one; PZ-51, DR-3305), is an organoselenium compound with glutathione peroxidase (GPx)-like, thiol-dependent, hydroperoxide reducing activity. As an enzyme mimic for activity of the selenoenzyme GPx, this compound has proved to be highly useful in research on mechanisms in redox biology.
Michael J, Parnham, Helmut, Sies
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Ebselen: prospective therapy for cerebral ischaemia
Expert Opinion on Investigational Drugs, 2000Stroke occurs due to haemorrhage or occlusive injury and results in ischaemia and reperfusion injury. A variety of destructive mechanisms are involved including oxygen radical generation, calcium overload, cytotoxicity and apoptosis as well as the generation of inflammatory mediators.
Helmut Sies +2 more
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Ebselen inhibition of apoptosis by reduction of peroxides
Biochemical Pharmacology, 1996We investigated the capacity of ebselen [2-phenyl-1,2-benzisoselenazol-3(2H)-one], a glutathione peroxidase mimic, to protect cells from radiation-induced apoptosis. Incubating mouse thymocytes with 25 microM ebselen immediately after 60Co gamma-radiation exposure (5 Gy) inhibited morphological changes associated with apoptosis. Treatment of thymocytes
N, Ramakrishnan +2 more
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Efficacy of the antioxidant ebselen in experimental uveitis
Free Radical Biology and Medicine, 1999Inflammation results in the production of free radicals. In a model of experimental uveitis upon subcutaneous injection of endotoxin to Lewis rats, i.e., endotoxin-induced experimental uveitis (EIU), we have evaluated the status of the antioxidant capacity of ocular tissues.
F, Bosch-Morell +5 more
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Investigating the Metabolic Mechanisms of Butaselen, An Ebselen Analog
Current Drug Metabolism, 2022Background: Butaselen is an ebselen analog that is under clinical trials for treating hepatic and pulmonary fibrosis. Our previous studies showed that butaselen is mainly present in human plasma in the form of M2, a free Se-methylated metabolite. Objective: This study aimed to investigate the metabolic mechanisms of butaselen. Methods and Results:
Qianqian, Tian +10 more
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Target discovery of ebselen with a biotinylated probe
Chemical Communications, 2018An activity-based protein profiling (ABPP) method for ebselen-binding proteins based on biotin-ebselen allowed for the robust identification of 462 targeted proteins, implicating multifunctional regulation of ebselen.
Zhenzhen Chen +9 more
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