Results 91 to 100 of about 112,556 (314)

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

EBV Positive Aggressive NK-Cell Leukemia

Online Journal of Health & Allied Sciences, 2021
Introduction: Aggressive NK cell leukemia (ANKL) is a rare malignant lymphoproliferative disorder of mature NK cells associated with poor overall survival.
Ankitha Hebbar, Ruchee Khanna, Sushma Belurkar, Shubham Varshney, Aradhana Harrison, Sindhura Lakshmi KL   +5 more
doaj  

A 5-year old male with “leukemic form” of disseminated post-transplant lymphoproliferative disorder

Pediatric Reports, 2010
Post-transplant lymphoproliferative disorder (PTLD) represents an abnormal lymphoid proliferation that occurs in recipients of solid organ or bone marrow allograft.
Saadiya Haque, Bhaskar Kallakury, Aziza Shad, Kristen Snyder   +3 more
doaj   +1 more source

A Tripartite Model for EBV‐Driven Multiple Sclerosis: B Cell Survival, Altered Self‐Presentation, and HLA‐DR15‐Restricted T Cell Cross‐Reactivity

iNew Medicine, EarlyView.
ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu, Arnaud John Kombe Kombe, Tengchuan Jin   +2 more
wiley   +1 more source

Ebna-1 Sequence Variations Reflect Active Ebv Replication and Disease Status or Quiescent Latency in Lymphocytes

, 2009
EBV infects most of the global population, but only a small percentage of infected individuals develop EBV-associated malignancies. Host and viral factors may play a role in determining the clinical outcome.
WANG, JIN-TOWN;SHEEN, TZUNG-SHIAHN;SU, IH-JEN;CHEN, JEN-YANG;CHEN, MEI-RU, 王錦堂;沈宗憲;蘇益仁;陳振陽;陳美如   +1 more
core  

Epstein-Barr virus latent proteins regulate expression of the anti-apoptotic cellular bfl-1 gene [PDF]

, 2005
The ubiquitous and oncogenic human herpes-virus Epstem-Barr virus (EB V) establishes a latent infection and promotes the long-term survival of the infected host cell by targeting the molecular machinery that controls cell fate decisions, including ...
Smith, Sinéad M.
core  

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

Interdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang, Jiayi Yao, Xinxian Zhao, Yan Xu, Yifan Chen, Tianchi Chen, Ying Jian, Min Li   +7 more
wiley   +1 more source

Ebstein-Barr virus- induced dacryoadenitis in a child: An unusual sign of a common disease and review of literature

Indian Journal of Ophthalmology. Case Reports
Lacrimal gland inflammation, known as dacryoadenitis, is an uncommon condition with various etiologies, ranging from infectious to autoimmune diseases. The clinical course can be acute, subacute, or chronic, with involvement on one or both sides.
Lisa Gamalero, Chiara Macucci, Mattia Pasti, Teresa Giani   +3 more
doaj   +1 more source

Complexities associated with expression of Epstein-Barr virus (EBV) lytic origins of DNA replication.

, 2007
EBV has two lytic origins (oriLyt) of DNA replication lying at divergent sites on the viral genome within a duplicated sequence (DS). The latter contains potential hairpin loops, ‘hinge’ elements and the promoters for transcripts from viral genes BHLF1 ...
Xue, SA, Griffin, BE
core  

Long-term carriers generate Epstein-Barr virus (EBV)-specific CD4 + and CD8 + polyfunctional T-cell responses which show immunodominance hierarchies of EBV proteins

, 2011
T cells simultaneously producing multiple cytokines and possessing cytotoxic capacity termed polyfunctional cells (PFCs) are increasingly recognized as the immune correlate of protection against pathogenic viruses.
Xu, XQ, Chan, KH, Ning, RJ, Chiang, AKS
core   +1 more source