Results 101 to 110 of about 121,594 (305)
Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li +7 more
wiley +1 more source
Profiling of EBV-Encoded microRNAs in EBV-Associated Hemophagocytic Lymphohistiocytosis
The Tohoku Journal of Experimental Medicine, 2015 Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) is a life-threatening complication of EBV infection. MicroRNAs (miRNAs) were small non-coding RNA, and EBV could encode miRNAs that are involved in the progression of infection. However, the profiles of EBV-miRNAs in EBV-HLH were unknown. Here, we aimed to profile the expression
Zhou, Chen +6 more
openaire +3 more sources
Aphasic status epilepticus due to Epstein–Barr virus meningoencephalitis – A clinical vignette
Epileptic Disorders, EarlyView.
Gemma Bassani +6 more
wiley +1 more source
JPGN Reports, EarlyView.Abstract Hyperornithinemia‐hyperammonemia‐homocitrullinuria (HHH) syndrome is a rare metabolic condition that can cause lethargy, ataxia, tachypnea, nausea, vomiting, seizures, coma, and acute liver failure. We present a 26‐month‐old female with acute liver failure who was diagnosed with HHH 1 week after admission. Histology revealed an acute hepatitic
Tierra L. Mosher +6 more
wiley +1 more source
, 2011 T cells simultaneously producing multiple cytokines and possessing cytotoxic capacity termed polyfunctional cells (PFCs) are increasingly recognized as the immune correlate of protection against pathogenic viruses.
Xu, XQ, Chan, KH, Ning, RJ, Chiang, AKS
core +1 more source
Refractory Eczema as a Presenting Feature of Common Variable Immunodeficiency
JEADV Clinical Practice, EarlyView.ABSTRACT Common variable immunodeficiency (CVID) is the most prevalent symptomatic inborn error of immunity (IEI) in adults. It presents with recurrent infections and non‐infectious complications, including autoimmunity, lymphoproliferation and dermatitis.
Mercedes Sanchez‐Diaz +2 more
wiley +1 more source
Control of the EBV growth transformation programme: the importance of the Bamhi W repeats [PDF]
, 2011 Epstein-Barr virus (EBV), a human gammaherpesvirus, possesses a unique set of latent genes whose constitutive expression in B cells leads to cell growth transformation.
Kao, Kuan-Yu
core +4 more sources
EBV-DNA in peripheral blood of mice inoculated with LCLs.
The EBV copy number in peripheral blood of mice inoculated with LCLs-WT and LCLs-dBNRF1 was quantified by qPCR analysis at the indicated time points. (TIFF)
Hitoshi Kiyoi (4458919) +9 more
core +1 more source
Juvenile Gangrenous Vasculitis of the Scrotum or Scrotum Lipschütz Ulcers
JEADV Clinical Practice, EarlyView.ABSTRACT Lipschütz genital ulcers are traditionally described in adolescent females and often linked to acute viral infections. Their male counterpart remains poorly characterised. We report a 59‐year‐old man with sudden onset of unilateral necrotic ulcers on the scrotum and inguinal region following a brief febrile episode and mild pharyngitis ...
Francesco Bellinato +2 more
wiley +1 more source
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors
Frontiers in Pharmacology, 2015 Human herpesviruses are widespread infectious pathogens that have been associated with proliferative and inflammatory diseases. During viral evolution, human herpesviruses have pirated genes encoding viral G protein-coupled receptors (vGPCRs), which are ...
Sabrina M de Munnik +3 more
doaj +1 more source