Results 41 to 50 of about 98,704 (296)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice

Nature Communications
De novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial CTPS1 deficiency in humans has previously been shown to lead to immunodeficiency, with impaired ...
Claire Soudais, Romane Schaus, Camille Bachelet, Norbert Minet, Sara Mouasni, Cécile Garcin, Caique Lopes Souza, Pierre David, Clara Cousu, Hélène Asnagli, Andrew Parker, Paul Palmquist-Gomes, Fernando E. Sepulveda, Sébastien Storck, Sigolène M. Meilhac, Alain Fischer, Emmanuel Martin, Sylvain Latour   +17 more
doaj   +1 more source

Molecular diagnostic of cytomegalovirus, Epstein Barr virus and Herpes virus 6 infections among blood donors by multiplex real-time PCR in Ouagadougou, Burkina Faso

The Pan African Medical Journal, 2016
INTRODUCTION: in most developing countries, Cytomegalovirus (CMV), Epstein Barr virus (EBV) and Herpes virus 6 (HHV-6) are not diagnosed in blood donors.
Lassina Traore, Issoufou Tao, Cyrille Bisseye, BiramaDiarra, Tegwinde Rebeca Compaore, Yacouba Nebie, Maleki Asshi, Alice Ouedraogo, Theodora Zohoncon, Florencia Djigma, Djénéba Ouermi, Nicolas Barro, Mahamoudou Sanou, Rasmata Traore Ouedraogo, Jacques Simpore   +14 more
doaj   +1 more source

Analysis of carcinogenic virus infection in HIV-infected patients

Shanghai yufang yixue, 2022
ObjectiveTo investigate the status of carcinogenic infection in people infected with HIV and those with negative HIV test results in VCT clinics. To analyze the epidemiological characteristics and provide scientific basis for more targeted disease ...
ZHANG Yong, XIN Xin, WANG Tao, WU Ping’an, CHEN Jing, LU Yihan   +5 more
doaj   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

Autophagy and immunity – insights from human herpesviruses

Frontiers in Immunology, 2012
The herpesviruses are a family of double-stranded DNA viruses that infect a large variety of organisms. Having co-evolved with their hosts over millennia, herpesviruses have developed a large repertoire of mechanisms to manipulate normal cellular ...
Luke eWilliams, Graham eTaylor
doaj   +1 more source

Differences in Epstein-Barr Virus Characteristics and Viral-Related Microenvironment Could Be Responsible for Lymphomagenesis in Children

Pathogens, 2020
In Argentina, Epstein-Barr virus (EBV) presence is associated with Hodgkin lymphoma (HL) in patients younger than 10 years, suggesting a relationship between low age of EBV infection and HL.
Aldana Vistarop, Oscar Jimenez, Melina Cohen, Elena De Matteo, Maria Victoria Preciado, Paola Chabay   +5 more
doaj   +1 more source

Deciphering novel host-herpesvirus interactions by proteomics

Frontiers in Microbiology, 2012
Over the years, a vast array of information concerning the interactions of viruses with their hosts has been collected. However, recent advances in proteomics and other system biology techniques suggest these interactions are far more complex than ...
Roger eLippé
doaj   +1 more source

Chronic active Epstein–Barr virus infection mimicking tuberculosis – A diagnostic enigma

Indian Journal of Pathology and Microbiology
Chronic active EBV infection is a rare disorder prone for misdiagnosis. They present with a wide range of symptoms from indolent to aggressive clinical course.
Shilpi Thakur, Manish Soneja, Deepam Pushpam, Saumyaranjan Mallick   +3 more
doaj   +1 more source

The role of toll-like receptor 9 (TLR9) in Epstein-Barr virus-associated gastric cancer

Current Issues in Pharmacy and Medical Sciences, 2020
Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is the most common malignancy caused by EBV infection. Toll-like receptors (TLRs) as major components of innate immune system are crucial in the development of inflammatory processes and ...
Dworzanska Anna, Strycharz-Dudziak Malgorzata, Dworzanski Jakub, Stec Agnieszka, Rajtar Barbara, Drop Bartlomiej, Polz-Dacewicz Malgorzata   +6 more
doaj   +1 more source