Results 51 to 60 of about 125,177 (307)

Disabling COMPASS Promoter Licensing Shifts HDAC‐Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery

Advanced Science, EarlyView.
Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song, Hui Yu, Jianping Jiang, Zhihui Jiang, Zhongshi Hong, Xu Zhang, Luchuan Chen, Shenghong Wei, Yi Wang   +8 more
wiley   +1 more source

Molecular diagnostic of cytomegalovirus, Epstein Barr virus and Herpes virus 6 infections among blood donors by multiplex real-time PCR in Ouagadougou, Burkina Faso

The Pan African Medical Journal, 2016
INTRODUCTION: in most developing countries, Cytomegalovirus (CMV), Epstein Barr virus (EBV) and Herpes virus 6 (HHV-6) are not diagnosed in blood donors.
Lassina Traore, Issoufou Tao, Cyrille Bisseye, BiramaDiarra, Tegwinde Rebeca Compaore, Yacouba Nebie, Maleki Asshi, Alice Ouedraogo, Theodora Zohoncon, Florencia Djigma, Djénéba Ouermi, Nicolas Barro, Mahamoudou Sanou, Rasmata Traore Ouedraogo, Jacques Simpore   +14 more
doaj   +1 more source

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

4 open, 2019
A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Autophagy and immunity – insights from human herpesviruses

Frontiers in Immunology, 2012
The herpesviruses are a family of double-stranded DNA viruses that infect a large variety of organisms. Having co-evolved with their hosts over millennia, herpesviruses have developed a large repertoire of mechanisms to manipulate normal cellular ...
Luke eWilliams, Graham eTaylor
doaj   +1 more source

The Novel Viral Non‐Coding RNA LMP2A‐IT1 Promotes the Lytic Replication of EBV

Advanced Science, EarlyView.
Decades after its discovery, EBV's genome still harbours unannotated “dark matter”. LMP2A‐IT1, a novel EBV‐encoded transcript identified in this work, is strongly upregulated during lytic replication and promotes BZLF1 expression, likely through activation of inflammatory responses, thereby enhancing viral propagation in a self‐reinforcing positive ...
Zheng‐Zhou Lu, Jun‐Fei Wu, Nannan Zhu, Ming‐Hui Yang, Le‐Le Zhang, Yuan‐Tao Liu, Wei‐Jun Chen, Jin‐Kun Tang, Jia‐Wei Ge, Chao‐Bo Lei, Tao Zhang, Yu Wang, Chao‐Yun Huang, Qian Zhong, Mu‐Sheng Zeng, Yan Li   +15 more
wiley   +1 more source

Epstein‐Barr Virus Transformed B Cells From Systemic Lupus Erythematosus and Multiple Sclerosis Patients Differ in EBV Lytic and Latency Marker Expression

Immunity, Inflammation and Disease
Epstein‐Barr virus (EBV) is an important environmental risk factor in the development of several autoimmune conditions, with the mechanisms still to be fully elucidated.
Ali Afrasiabi, Wade J. Bocking, Stephen D. Schibeci, Samantha P. L. Law, Nicole L. Fewings, Ming‐Wei Lin, Stephen J. Sawcer, Maria Ban, Sanjay Swaminathan, Grant P. Parnell   +9 more
doaj   +1 more source

Deciphering novel host-herpesvirus interactions by proteomics

Frontiers in Microbiology, 2012
Over the years, a vast array of information concerning the interactions of viruses with their hosts has been collected. However, recent advances in proteomics and other system biology techniques suggest these interactions are far more complex than ...
Roger eLippé
doaj   +1 more source

Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study. [PDF]

, 2011
BACKGROUND: The prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low in rural populations and some non-affluent countries.
Cruz Álvaro C, Dattoli, VC, Cunha, SS, Rodrigues, LC, Veiga, Rafael V., Veiga Rafael V, Cunha, Sergio S., Neuza M Alcantara-Neves, Cunha, Sergio S, Barreto, Maurício L., Veiga, Rafael V, Barreto, Maurício L, Cruz, Álvaro C., Dattoli, Vitor CC, Dattoli, Vitor C. C., Maurício L Barreto, Cunha Sergio S, Alcantara-Neves Neuza M, Sergio S Cunha, Vitor CC Dattoli, Rafael V Veiga, Alcantara-Neves, Neuza M., Dattoli Vitor CC, Alcantara-Neves, Neuza M, Rodrigues Laura C, Cruz, ÁC, Álvaro C Cruz, Phillip J Cooper, Laura C Rodrigues, Cruz, Álvaro C, Barreto, ML, Cooper, Phillip J, Rodrigues, Laura C., Alcantara-Neves, NM, Rodrigues, Laura C, Veiga, RV, Cooper, PJ, Cooper, Philip, Barreto Maurício L, Cooper Phillip J   +39 more
core   +2 more sources

Epigenetic Activation of ANGPTL4 Drives EBV‐Negative Gastric Cancer via Neutrophil Recruitment and NET Release via Stabilizing ANXA5

Advanced Science, EarlyView.
ANGPTL4 exhibits distinct promoter methylation patterns and expression profiles in EBV‐positive versus EBV‐negative gastric cancer. Secreted C‐terminal ANGPTL4 (cANGPTL4) acts as the dominant functional isoform driving GC proliferation, EMT, and neutrophil infiltration. cANGPTL4 promotes neutrophil recruitment via NF‐κB/CXCL8 axis.
Dandan Li, Xinqi Li, Xiangyin Luo, Jiayi Wang, Yiwei Zha, Zeng Zhou, Yanyan Chen, Qi Wang, Lingyun Xia, Weidong Leng, Shanshan Qin   +10 more
wiley   +1 more source

Chronic active Epstein–Barr virus infection mimicking tuberculosis – A diagnostic enigma

Indian Journal of Pathology and Microbiology
Chronic active EBV infection is a rare disorder prone for misdiagnosis. They present with a wide range of symptoms from indolent to aggressive clinical course.
Shilpi Thakur, Manish Soneja, Deepam Pushpam, Saumyaranjan Mallick   +3 more
doaj   +1 more source