Results 41 to 50 of about 121,594 (305)

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

Inactivation of cytidine triphosphate synthase 1 prevents fatal auto-immunity in mice

Nature Communications
De novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and −2. Partial CTPS1 deficiency in humans has previously been shown to lead to immunodeficiency, with impaired ...
Claire Soudais, Romane Schaus, Camille Bachelet, Norbert Minet, Sara Mouasni, Cécile Garcin, Caique Lopes Souza, Pierre David, Clara Cousu, Hélène Asnagli, Andrew Parker, Paul Palmquist-Gomes, Fernando E. Sepulveda, Sébastien Storck, Sigolène M. Meilhac, Alain Fischer, Emmanuel Martin, Sylvain Latour   +17 more
doaj   +1 more source

CTPS2 regulates CTP synthetase activity by interacting with CTPS1

Life Science Alliance
The human CTP synthetases 1 and 2 associate together and co-localize in large filament–cytoophidium structures. CTPS1 and CTPS2 association results in enzymatic modulation independently of cytoophidia revealing a new regulation mechanism of CTP ...
Norbert Minet, Benoît Heid-Picard, Vanessa Masson, Damarys Loew, Emmanuel Martin, Sylvain Latour   +5 more
doaj   +1 more source

Analysis of carcinogenic virus infection in HIV-infected patients

Shanghai yufang yixue, 2022
ObjectiveTo investigate the status of carcinogenic infection in people infected with HIV and those with negative HIV test results in VCT clinics. To analyze the epidemiological characteristics and provide scientific basis for more targeted disease ...
ZHANG Yong, XIN Xin, WANG Tao, WU Ping’an, CHEN Jing, LU Yihan   +5 more
doaj   +1 more source

Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study

Arthritis Care &Research, EarlyView.
Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali, Thomas Khoo, Keeran Shivakumar, Adam Caroll, Lauren Hender, Dimitra Beroukas, Kim Griggs, Celina Jin, Theo De Malmanche, Jessica Day, Gabor Major, Vidya Limaye   +11 more
wiley   +1 more source

Telomeres and Viruses: Common Themes of Genome Maintenance

Frontiers in Oncology, 2012
Genome maintenance mechanisms actively suppress genetic instability associated with cancer and aging. Some viruses provoke genetic instability by subverting the host’s control of genome maintenance.
Zhong eDeng, Zhuo eWang, Paul M Lieberman   +2 more
doaj   +1 more source

The role of Toll-like receptors (TLRs) in virus-related cancers: a mini review

Current Issues in Pharmacy and Medical Sciences, 2020
The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human Epstein-Barr (EBV) and Papillomavirus-(HPV) related cancers.
Dworzanska Anna, Polz-Dacewicz Małgorzata   +1 more
doaj   +1 more source

Differences in Epstein-Barr Virus Characteristics and Viral-Related Microenvironment Could Be Responsible for Lymphomagenesis in Children

Pathogens, 2020
In Argentina, Epstein-Barr virus (EBV) presence is associated with Hodgkin lymphoma (HL) in patients younger than 10 years, suggesting a relationship between low age of EBV infection and HL.
Aldana Vistarop, Oscar Jimenez, Melina Cohen, Elena De Matteo, Maria Victoria Preciado, Paola Chabay   +5 more
doaj   +1 more source

EBV-CN and clinicopathological characteristics of EBVaGC.

, 2019
EBV-CN and clinicopathological characteristics of EBVaGC.
Ruri Saito (6274076), Akiko Kunita (828998), Teru Kanda (196397), Shumpei Ishikawa (154679), Hiroharu Yamashita (63250), Masashi Fukayama (154693), Hiroyuki Abe (633475), Yasuyuki Seto (514783), Atsuhito Nakayama (2633254)   +8 more
core   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source